期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 34, 页码 19104-19111出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b04569
关键词
Layered double hydroxide; layer-by-layer; covalent stabilization; etching; controlled drug release
资金
- Fundamental Research Funds for Central Universities [2-9-2013-49, 2-9-2014-123]
A stable drug release system with magnetic targeting is essential in a drug delivery system. In the present work, layered double hydroxide assemblies stabilized by layer-by-layer polymer multilayers were prepared by alternative deposition of poly(allylamine hydrochloride) and poly(acrylic acid) species on composite particles of Fe3O4 and ZnAl-LDH and then covalent cross-linkage of the polymer multilayers by photosensitive cross-linker. The successful fabrication was recorded by Zeta potential and Fourier transform infrared spectrum measurements. The formed assemblies were stable in high pH solutions (pH > 7). The drug loading capacity and release behavior of the assemblies could be controlled by treatment with appropriate acidic solution, and were confirmed by loading and release of a simulated drug, methylene blue. The formed assemblies possessed enough saturated magnetic strength and were sensitive to external magnetic field which was essential for targeting drug delivery. The formed assemblies were multifunctional assemblies with great potential as drug delivery system.
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