期刊
APPLIED PHYSICS LETTERS
卷 93, 期 6, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.2971030
关键词
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资金
- Swedish Research Council
- Swedish Foundation for Strategic Research
- European Community [NMP4-CT-2004-500039]
We demonstrate enrichment, controlled aggregation, and manipulation of microparticles and cells by an ultrasonic cage integrated in a microfluidic chip compatible with high-resolution optical microscopy. The cage is designed as a dual-frequency resonant filleted square box integrated in the fluid channel. Individual particles may be trapped three dimensionally, and the dimensionality of one-dimensional to three-dimensional aggregates can be controlled. We investigate the dependence of the shape and position of a microparticle aggregate on the actuation voltages and aggregate size, and demonstrate optical monitoring of individually trapped live cells with submicrometer resolution. (C) 2008 American Institute of Physics.
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