Article
Cardiac & Cardiovascular Systems
G. Michael Deeb, Michael J. Reardon, Basel Ramlawi, Steven J. Yakubov, Stan J. Chetcuti, Neal S. Kleiman, Abeel A. Mangi, Firas Zahr, Howard K. Song, Hemal Gada, Mubashir Mumtaz, John Heiser, William Merhi, C. Patrick Murrah, Thomas Noel, Merick Kirshner, Timothy Byrne, Saki Ito, Jian Huang, John K. Forrest
Summary: The aim of this study was to compare 1-year outcomes after transcatheter aortic valve replacement (TAVR) in low surgical risk patients with bicuspid aortic stenosis to patients with tricuspid aortic stenosis. The results showed that there were no significant differences in clinical or forward flow hemodynamic outcomes between the two groups at 1 year.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Alberto Alperi, Mathieu Robichaud, Vassili Panagides, Jules Mesnier, Jorge Nuche, Jean-Michel Paradis, Robert Delarochelliere, Dimitri Kalavrouziotis, Eric Dumont, Siamak Mohammadi, Josep Rodes-Cabau
Summary: High postprocedural mean transvalvular gradients following ViV-TAVR as evaluated by echocardiography were not associated with negative effects on clinical outcomes including major adverse events, functional status, exercise capacity, and quality of life parameters.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Harish Sharma, Shazia Afzal, Juergen Leick, Nikos Werner, Sagar N. Doshi, M. Adnan Nadir
Summary: This review aims to provide clinicians with guidance on the optimal antithrombotic strategy post-TAVR, taking into consideration different patient populations and the limitations of existing guidelines.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Yi-Ming Li, Tian-Yuan Xiong, Kai Xu, Zhen-Fei Fang, Lei Jiang, Jun Jin, Sheng-Hu He, Yi-Ning Yang, Jing-Jing He, Yu-Heng Jia, Yi Zhang, Yong Peng, Yuan Feng, Mao Chen
Summary: This study delineated the clinical characteristics and outcomes of Chinese TAVR patients, finding that TAVR candidates in China had lower rates of complications and mortality compared to other international registries, and patients with BAV had lower mortality rates. These results suggest that the application of TAVR in low-risk patients will be further propelled.
CHINESE MEDICAL JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Troels Hojsgaard Jorgensen, Hans Gustav Horsted Thyregod, Nikolaj Ihlemann, Henrik Nissen, Petur Petursson, Bo Juel Kjeldsen, Daniel Andreas Steinbruchel, Peter Skov Olsen, Lars Sondergaard
Summary: In patients with severe aortic valve stenosis at low surgical risk randomized to TAVI or SAVR, there were no significant differences in the risk for all-cause mortality, stroke, or myocardial infarction, as well as the risk of bioprosthetic valve failure after 8 years of follow-up. However, patients who underwent TAVI had a lower risk of structural valve deterioration compared to those who underwent SAVR.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Troels Hojsgaard Jorgensen, Hans Gustav Horsted Thyregod, Nikolaj Ihlemann, Henrik Nissen, Petur Petursson, Bo Juel Kjeldsen, Daniel Andreas Steinbruchel, Peter Skov Olsen, Lars Sondergaard
Summary: In a study comparing clinical outcomes and valve durability after 8 years of follow-up in patients with symptomatic severe aortic valve stenosis at low surgical risk treated with either transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR), no significant differences were found in the risk for all-cause mortality, stroke, or myocardial infarction, as well as the risk of bioprosthetic valve failure between the two groups.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Alberto Alperi, Josep Rodes-Cabau, Matheus Simonato, Didier Tchetche, Gaetan Charbonnier, Henrique B. Ribeiro, Azeem Latib, Matteo Montorfano, Marco Barbanti, Sabine Bleiziffer, Bjorn Redfors, Mohamed Abdel-Wahab, Abdelhakim Allali, Giuseppe Bruschi, Massimo Napodano, Marco Agrifoglio, Anna Sonia Petronio, Cristina Giannini, Albert Chan, Ran Kornowski, Nili Schamroth Pravda, Matti Adam, Alessandro Iadanza, Stephane Noble, Andrew Chatfield, Magdalena Erlebach, Joerg Kempfert, Timm Ubben, Harindra Wijeysundera, Moritz Seiffert, Thomas Pilgrim, Won-Keun Kim, Luca Testa, David Hildick-Smith, Roberto Nerla, Claudia Fiorina, Christina Brinkmann, Lars Conzelmann, Didier Champagnac, Francesco Saia, Henrik Nissen, Hafid Amrane, Brian Whisenant, Jasmin Shamekhi, Lars Sondergaard, John G. Webb, Danny Dvir
Summary: In a large series of ViV-TAVR procedures, the incidence of periprocedural PPI was relatively low and decreased with the use of new-generation THV systems. Older age, larger THV size, and previous right bundle branch block were associated with an increased risk of PPI. Although there were no significant differences in 30-day mortality between the PPI and no-PPI groups, PPI patients exhibited a trend toward higher mortality risk at follow-up.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Po-Han Lin, Hao-Ji Wei, Shih-Rong Hsieh, Hung-Wen Tsai, Chu-Leng Yu, Wen-Lieng Lee, Yung-Szu Wu
Summary: The aim of the study was to provide real-world data on outcomes for elderly Taiwanese patients who underwent transcatheter aortic valve replacement or surgical aortic valve replacement in different risk groups. The results showed that in all risk groups, patients in the TAVI group had shorter hospital stay and higher rate of paravalvular leakage compared to the SAVR group, but there were no significant differences in mortality rates between the two groups. Risk factors for higher 1-year and 5-year mortality included BMI less than 20 and acute kidney injury.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
John K. Forrest, G. Michael Deeb, Steven J. Yakubov, Hemal Gada, Mubashir A. Mumtaz, Basel Ramlawi, Tanvir Bajwa, Paul S. Teirstein, Michael DeFrain, Murali Muppala, Bruce J. Rutkin, Atul Chawla, Bart Jenson, Stanley J. Chetcuti, Robert C. Stoler, Marie-France Poulin, Kamal Khabbaz, Melissa Levack, Kashish Goel, Didier Tchetche, Ka Yan Lam, Pim A. L. Tonino, Saki Ito, Jae K. Oh, Jian Huang, Jeffrey J. Popma, Neal Kleiman, Michael J. Reardon, Low Risk Trial Investigators
Summary: This study evaluated the clinical and echocardiographic outcomes of transcatheter aortic valve replacement (TAVR) compared with surgery in low-risk patients at 3 years. It found that TAVR showed durable benefits compared with surgery in terms of reducing the incidence of all-cause mortality or disabling stroke, and also significantly improved valve hemodynamics in patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Michael J. Reardon, Bassem Chehab, Dave Smith, Antony S. Walton, Stephen G. Worthley, Ganesh Manoharan, Ibrahim Sultan, Gerald Yong, Katherine Harrington, Paul Mahoney, Neal Kleiman, Raj R. Makkar, Gregory Fontana, Augustin DeLago, Ravi K. Ramana, Nicholas Bates, Lars Sondergaard
Summary: The PORTICO NG study evaluated the safety and effectiveness of the Navitor valve in high-risk patients with severe aortic stenosis. The results showed that the Navitor valve is safe and effective for treating severe aortic stenosis, with low rates of adverse events and paravalvular leak.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Martin B. Leon, Michael J. Mack, Rebecca T. Hahn, Vinod H. Thourani, Raj Makkar, Susheel K. Kodali, Maria C. Alu, Mahesh V. Madhavan, Katherine H. Chau, Mark Russo, Samir R. Kapadia, S. Chris Malaisrie, David J. Cohen, Philipp Blanke, Jonathon A. Leipsic, Mathew R. Williams, James M. McCabe, David L. Brown, Vasilis Babaliaros, Scott Goldman, Howard C. Herrmann, Wilson Y. Szeto, Philippe Genereux, Ashish Pershad, Michael Lu, John G. Webb, Craig R. Smith, Philippe Pibarot
Summary: In low surgical risk patients with symptomatic severe aortic stenosis, the PARTNER 3 trial showed superiority of transcatheter aortic valve replacement (TAVR) over surgery for the primary endpoint at 1 year. However, at 2 years, differences in death and stroke between TAVR and surgery were no longer significant, and TAVR patients had an increased risk of valve thrombosis.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jun Shi, Lai Wei, Yucheng Chen, Xu Wang, Jian Ye, Chaoyi Qin, Lulu Liu, Hong Qian, Chunsheng Wang, Yingqiang Guo
Summary: The study showed good midterm outcomes of transcatheter aortic valve implantation with the J-Valve system in treating patients with aortic stenosis or pure aortic insufficiency, suggesting it as a promising alternative therapy for high-risk patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Jing-Jing He, Tian-Yuan Xiong, Yi-Jun Yao, Yong Peng, Jia-Fu Wei, Sen He, Yong Chen, Qiao Li, Zhen-Gang Zhao, Xin Wei, Wen-Xia Zhou, Yu-Jia Liang, Hong Tang, Guo Chen, Xuan Zhou, Ming-Xia Zheng, Wei Meng, Yan-Biao Liao, Yi-Jian Li, Yi-Ming Li, Fei Chen, Yuan-Weixiang Ou, Qi Liu, Xi Li, Xi Wang, Yi Zhang, Zhong-Kai Zhu, Hao-Ran Yang, Kai-Yu Jia, Mao Chen, Yuan Feng
Summary: This study investigated the impact of sex on outcomes following transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valves (BAVs). The results showed that women with BAVs had fewer comorbidities, while men had a higher proportion of type 1 BAV, more calcification, and larger aortic roots. Men had better in-hospital outcomes, except for the need for second valve implantation, but 1-year survival was comparable between sexes.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Medicine, General & Internal
Stefano Rosato, Fausto Biancari, Paola D'Errigo, Marco Barbanti, Giuseppe Tarantini, Francesco Bedogni, Marco Ranucci, Giuliano Costa, Tatu Juvonen, Gian Paolo Ussia, Andrea Marcellusi, Giovanni Baglio, Stefano Domenico Cicala, Gabriella Badoni, Fulvia Seccareccia, Corrado Tamburino
Summary: The study demonstrates that in a real-world setting, TAVR was associated with lower rates of adverse events and better outcomes compared to SAVR in treating patients with severe aortic stenosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yaoyao Zhou, Qifeng Zhu, Po Hu, Huajun Li, Xinping Lin, Xianbao Liu, Zhaoxia Pu, Jian'an Wang
Summary: This study aimed to investigate the short-term trajectory of NT-proBNP following TAVR and its association with clinical outcomes in TAVR recipients. Three distinct NT-proBNP trajectories were identified, and patients with different trajectories had significantly different risks of all-cause death and cardiac death. These findings highlight the prognostic value of NT-proBNP trajectory in TAVR recipients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)