Article
Clinical Neurology
Imran H. Iftikhar, Peter A. Cistulli, Haitham Jahrami, Khalid A. Alamoud, Maarij Saeed, Andrew P. Soulimiotis, Ahmed S. BaHammam
Summary: The study analyzed the relative efficacies of mandibular advancement devices (MAD) in sleep apnea treatment and found some differences in efficacy based on different sleep apnea treatment outcomes and phenotypes. However, there were no statistically significant differences between MADs in the outcomes analyzed, indicating that further research may be needed to determine the most effective MAD for specific sleep apnea conditions.
SLEEP AND BREATHING
(2023)
Article
Medicine, General & Internal
Caterina Antonaglia, Gabriele Vidoni, Luca Contardo, Fabiola Giudici, Francesco Salton, Barbara Ruaro, Marco Confalonieri, Martina Caneva
Summary: The presence of low arousal threshold may predict poor response to mandibular advancement device treatment, as shown in this study.
Review
Clinical Neurology
Julia A. M. Uniken Venema, Boudewijn R. A. M. Rosenmoller, Nico de Vries, Jan de Lange, Ghizlane Aarab, Frank Lobbezoo, Aarnoud Hoekema
Summary: This systematic review summarized the objective and subjective outcomes of different available Mandibular Advancement Device (MAD) designs in treating Obstructive Sleep Apnea (OSA). It found that Monoblock appliances performed better than bilateral thrust, midline traction appliances performed better than other designs, and custom appliances performed better than thermoplastic appliances. However, there were no clinically relevant differences between MAD designs in reduction of ESS, compliance, preference, side effects, and cost effectiveness.
SLEEP MEDICINE REVIEWS
(2021)
Review
Clinical Neurology
Sara Camanes-Gonzalvo, Carlos Bellot-Arcis, Rocio Marco-Pitarch, Jose M. Montiel-Company, Marina Garcia-Selva, Ruben Agustin-Panadero, Vanessa Paredes-Gallardo, Francisco J. Puertas-Cuesta
Summary: This systematic review investigates the efficacy of oral appliance therapy for obstructive sleep apnea and identifies predictors of treatment response. The study findings suggest that younger patients with smaller neck circumference and lower body mass index exhibited better treatment outcomes.
SLEEP MEDICINE REVIEWS
(2022)
Review
Medicine, General & Internal
Meghana Pattipati, Goutham Gudavalli, Matthew Zin, Lohitha Dhulipalla, Essasani Kolack, Monika Karki, Pradeep Kumar Devarakonda, Linus Yoe
Summary: CPAP remains the gold standard for the treatment of obstructive sleep apnea (OSA), while MAD can be used as an adjunctive treatment or for patients who cannot readily access or do not prefer CPAP.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Clinical Neurology
Francesco Di Bello, Luigi Napolitano, Marco Abate, Claudia Colla Ruvoloa, Simone Morra, Gianluigi Califano, Marco Capece, Massimiliano Creta, Cristiano Scandurra, Benedetta Muzii, Claudio Di Nola, Vincenzo Bochicchio, Riccardo Nocini, Vincenzo Abbate, Nelson Mauro Maldonato, Giovanni Dell ' Aversana Orabona, Nicola Longo, Elena Cantone
Summary: Lower urinary tract symptoms, especially nocturia, are a significant public health problem worldwide, particularly in elderly individuals, and are associated with sleep disorders and obstructive sleep apnea syndrome. However, the causes and pathophysiology of nocturia in OSAS patients have not been thoroughly examined. The effect of treatment on managing nocturia in OSAS patients also remains unclear.
SLEEP MEDICINE REVIEWS
(2023)
Article
Medicine, Research & Experimental
Julianna Rodin, Michele Fiorella, Meghan Crippen, Keisha Best, Daniel Taub, Allen Champion, Maurits Boon, Colin Huntley
Summary: Less than half of patients referred for MMA followed up, and less than half of those patients underwent MMA. Most patients cited concerns about the invasiveness of the surgery and recovery process.
Article
Dentistry, Oral Surgery & Medicine
Xiaoxin Shi, Frank Lobbezoo, Hui Chen, Boudewijn R. A. M. Rosenmoller, Erwin Berkhout, Jan de Lange, Ghizlane Aarab
Summary: The study aimed to compare the effects of mandibular advancement device (MAD) therapy on upper airway dimensions between responders and non-responders with mild to moderate obstructive sleep apnea (OSA). The results showed no significant differences in the changes of the upper airway dimensions induced by MADs between responders and non-responders.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Medicine, General & Internal
Sara Camanes-Gonzalvo, Rocio Marco-Pitarch, Andres Plaza-Espin, Javier Puertas-Cuesta, Ruben Agustin-Panadero, Antonio Fons-Font, Carla Fons-Badal, Marina Garcia-Selva
Summary: The mandibular advancement device was effective in improving polysomnographic parameters and significantly increasing the tridimensional dimensions of the upper airway in patients with obstructive sleep apnea. These improvements were correlated with a reduction in the apnea hypopnea index and an increase in the minimum oxygen saturation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biology
Hiroshi Suzuki, Toshiyuki Nakayama, Arisa Sawa, Tatsuo Yagi, Yoshihiro Iwata, Hiroki Takeuchi, Miho Motoyoshi, Chin-Moi Chow, Osamu Komiyama
Summary: This study assessed the sleep quality and therapeutic effects of a custom-made mandibular advancement device (MAD) in male Japanese elite rugby athletes. The results showed that a majority of the participants had poor sleep quality and were diagnosed with obstructive sleep apnea (OSA). MAD therapy significantly improved sleep quality and reaction times.
Review
Health Care Sciences & Services
Sy Duong-Quy, Hoang Nguyen-Huu, Dinh Hoang-Chau-Bao, Si Tran-Duc, Lien Nguyen-Thi-Hong, Thai Nguyen-Duy, Tram Tang-Thi-Thao, Chandat Phan, Khue Bui-Diem, Quan Vu-Tran-Thien, Thu Nguyen-Ngoc-Phuong, Vinh Nguyen-Nhu, Huong Le-Thi-Minh, Timothy Craig
Summary: Obstructive Sleep Apnea (OSA) is a common disease that is often underestimated and undertreated in all age groups. Personalized diagnosis and treatment approaches are necessary for clinical practice due to morphological differences, clinical phenotype diversity, and variations in diagnosis and treatment of OSA in children and adults. Treatment should be based on individual tolerance to sleep-quality-related parameters, the harmful effects of hypoxia on the cardiovascular system, and patients' comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ronni Baran, Daniela Grimm, Manfred Infanger, Markus Wehland
Summary: OSA is a common disease affecting millions worldwide, with CPAP therapy being a common treatment method to prevent complications such as hypertension by improving airway patency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Yao Hao Teo, Ruobing Han, Shariel Leong, Yao Neng Teo, Nicholas L. Syn, Caitlin Fern Wee, Benjamin Kye Jyn Tan, Raymond C. C. Wong, Ping Chai, Pipin Kojodjojo, William Kf Kong, Chi-Hang Lee, Ching-Hui Sia, Tiong-Cheng Yeo
Summary: This study found a high comorbid disease burden between obstructive sleep apnea and bradycardia, while continuous positive airway pressure therapy seemed to have no significant reduction in the risk of bradycardia.
Article
Clinical Neurology
Ning Zhou, Jean-Pierre T. F. Ho, Zhengfei Huang, Rene Spijker, Nico de Vries, Ghizlane Aarab, Frank Lobbezoo, Madeline J. L. Ravesloot, Jan de Lange
Summary: Both MMA and MLS are effective treatment options for OSA, with MMA potentially being more effective in improving OSA but associated with a higher complication rate.
SLEEP MEDICINE REVIEWS
(2021)
Article
Respiratory System
Gonzalo Labarca, Scott A. Sands, Vicki Cohn, Gail Demko, Daniel Vena, Ludovico Messineo, Laura Gell, Lauren Hess, David P. White, Andrew Wellman, Ali Azarbarzin
Summary: The combination of an adhesive mouthpiece and mandibular advancement devices (MAD) is more effective in treating obstructive sleep apnea (OSA) than MAD alone, improving the efficacy of treatment and potentially influencing clinical decision making.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Clinical Neurology
Thomas Gaisl, Albina Nowak, Noriane A. Sievi, Nicolas Gerard, Christian F. Clarenbach, Malcolm Kohler, Daniel Franzen
SLEEP AND BREATHING
(2020)
Article
Respiratory System
Thomas Gaisl, Patrick Baumgartner, Protazy Rejmer, Martin Osswald, Maurice Roeder, Sira Thiel, Simon F. Staempfli, Christian F. Clarenbach, Felix C. Tanner, Malcolm Kohler
Article
Clinical Neurology
Fabian A. Grewe, Maurice Roeder, Matteo Bradicich, Esther I. Schwarz, Ulrike Held, Sira Thiel, Thomas Gaisl, Noriane A. Sievi, Malcolm Kohler
JOURNAL OF CLINICAL SLEEP MEDICINE
(2020)
Letter
Clinical Neurology
Fabian A. Grewe, Thomas Gaisl, Malcolm Kohler
JOURNAL OF CLINICAL SLEEP MEDICINE
(2020)
Article
Clinical Neurology
Fabian A. Grewe, Matteo Bradicich, Thomas Gaisl, Maurice Roeder, Sira Thiel, Noriane A. Sievi, Malcolm Kohler
Review
Respiratory System
Maurice Roeder, Matteo Bradicich, Esther Irene Schwarz, Sira Thiel, Thomas Gaisl, Ulrike Held, Malcolm Kohler
Article
Cardiac & Cardiovascular Systems
Maurice Roeder, Sira Thiel, Frederic Baumann, Noriane A. Sievi, Marianne Rohrbach, Malcolm Kohler, Thomas Gaisl
BMC CARDIOVASCULAR DISORDERS
(2020)
Article
Critical Care Medicine
Maurice Roeder, Noriane A. Sievi, Matteo Bradicich, Fabian A. Grewe, Sandra Siegfried, Thomas Gaisl, Malcolm Kohler
Summary: The study found that the first night of at-home pulse oximetry monitoring showed high sensitivity and specificity for diagnosing moderate OSA, making it an effective diagnostic tool. Conducting multiple nights of monitoring, such as using real-time oxygen saturation monitoring, can increase the accuracy of diagnosing moderate OSA.
Article
Respiratory System
Thomas Gaisl, Protazy Rejmer, Maurice Roeder, Patrick Baumgartner, Noriane A. Sievi, Sandra Siegfried, Simon F. Staempfli, Robert Thurnheer, John R. Stradling, Felix C. Tanner, Malcolm Kohler
Summary: This study found that OSA may be a modest but independent risk factor for faster TAA expansion, potentially contributing to life-threatening complications in aortic disease. There was no association between OSA severity and aortic events in the participants.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Letter
Respiratory System
Thomas Gaisl, Chris D. Turnbull, Gerrit Weimann, Sigrun Unger, Rudolf Finger, Charles Xing, Peter A. Cistulli, Sophie West, Alan K. I. Chiang, Danny J. Eckert, John R. Stradling, Malcolm Kohler
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Cell Biology
Nora Nowak, Thomas Gaisl, Djordje Miladinovic, Ricards Marcinkevics, Martin Osswald, Stefan Bauer, Joachim Buhmann, Renato Zenobi, Pablo Sinues, Steven A. Brown, Malcolm Kohler
Summary: Using exhaled breath analysis, this study found that different vigilance states during sleep rapidly and reversibly control major metabolic pathways, with wake reducing fatty acid oxidation, slow-wave sleep increasing it, and rapid eye movement sleep resulting in elevation of tricarboxylic acid cycle intermediates. This complex orchestration between sleep and wake likely plays an important role in optimizing metabolic circuits for human performance and health.
Article
Environmental Sciences
Ugo Fedeli, Claudio Barbiellini Amidei, Alessandro Marcon, Veronica Casotto, Francesco Grippo, Enrico Grande, Thomas Gaisl, Stefano Barco
Summary: The COVID-19 pandemic may have led to an underestimation of mortality related to Chronic Obstructive Pulmonary Disease (COPD). A study conducted in Veneto, Italy analyzed death certificates from 2008 to 2020 and found that COPD-related deaths increased by 16% in 2020 compared to previous years, with peaks corresponding to the COVID-19 epidemic waves.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Felix Schmidt, Nora Nowak, Patrick Baumgartner, Thomas Gaisl, Stefan Malesevic, Bettina Streckenbach, Noriane A. Sievi, Esther Schwarz, Renato Zenobi, Steven A. Brown, Malcolm Kohler
Summary: This study aims to apply the latest findings on vigilance-state-dependent metabolism in healthy subjects to OSA patients, and investigate how symptomatic OSA affects metabolism, and whether these changes can explain the metabolic and cardiovascular consequences of OSA. The results show that there are differences in metabolism between symptomatic OSA patients and the control group, involving major metabolic pathways in carbohydrate, amino acid, and lipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Carolin Steinack, Helene Balmer, Silvia Ulrich, Thomas Gaisl, Daniel P. Franzen
Summary: This pilot study evaluated the risks and feasibility of using one-lung ventilation (OLV) through a single-lumen endotracheal tube (SLT) during rigid bronchoscopy (RB) in patients with malignant airway stenosis. The study found that OLV using an SLT during RB could be a new treatment approach for endobronchial ablative procedures without increasing bronchoscopy-associated risks, allowing concurrent high-energy treatments.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick Baumgartner, Protazy Rejmer, Martin Osswald, Stefan Malesevic, Noriane A. Sievi, Maurice Roeder, Jonas Herth, Simon F. Staempfli, Christian F. Clarenbach, Felix C. Tanner, Thomas Gaisl, Malcolm Kohler
Summary: Thoracic aortic aneurysms (TAA) can have fatal complications such as rupture and dissection. This study aimed to assess if there are differences in wall properties between patients with TAA and a matched control group. The results showed that patients with TAA had comparable arterial wall properties to the matched control group. Further investigation is needed to determine if increased central arterial stiffness is a relevant factor in the emergence of TAA.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)