Fungal microsclerotia development: essential prerequisites, influencing factors, and molecular mechanism

Microsclerotia (MS) consist of an outer layer of pigment parenchyma cells and an inner layer of colorless medulla cells. In nature, MS are formed as overwintering and spreading structures in phytopathogenic fungi. For biological applications, MS can be induced in artificial liquid medium. To understand the complicated structure of MS and molecular mechanism of MS development in entomopathogenic and phytopathogenic fungi, data from different studies can be integrated. In this review, the essential prerequisites, environmental cues, and internal stimulating factors for MS development are explored. Emerging knowledges about the association between transcriptional regulatory circuits and signaling pathways involved in MS development in entomopathogenic and phytopathogenic fungi is also highlighted.