Article
Pharmacology & Pharmacy
Qing Hu, Xiaoling Fu, Yanping Su, Yanfang Wang, Sihuan Gao, Xiaoqin Wang, Ying Xu, Changxi Yu
Summary: This study successfully improved the bioavailability of Koumine (KME) by optimizing the synthesis of inclusion complexes, resulting in enhanced solubility and intestinal absorption efficiency.
Article
Chemistry, Physical
Tatyana V. Volkova, Olga R. Simonova, German L. Perlovich
Summary: This study investigates the physicochemical properties of the novel potential antifungal compound TZD in the presence of 2HP-beta-CD, focusing on solubility, distribution, and membrane permeability. The experiments were carried out at different temperatures and pH values to predict the behavior of TZD in biological media. The results provide insights into the role of hydrogen bonding and the permeation of TZD across stomach and intestine membranes.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Neurosciences
Danielle A. Becktel, Jacob C. Zbesko, Jennifer B. Frye, Amanda G. Chung, Megan Hayes, Kylie Calderon, Jeffrey W. Grover, Anna Li, Frankie G. Garcia, Marco A. Tavera-Garcia, Rick G. Schnellmann, Hsin-Jung Joyce Wu, Thuy-Vi V. Nguyen, Kristian P. Doyle
Summary: This study suggests that systemic treatment with HP beta CD after stroke can attenuate chronic inflammation, prevent neurodegeneration, and improve cognitive function.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jianqing Su, Xinyu Zhang, Shengliang Cao, Cheng Liu, Xiang Fu, Rui Zhang, Xiaoli Li, Jiaojiao Xue, Ying Li, Xueyan Wang, Yi Ding, Yubao Li, Xiuling Chu
Summary: An inclusion complex formed with cyclodextrin can improve the bioavailability of water-insoluble drugs. The pharmacokinetic characteristics of Hyperoside-2-hydroxypropyl-beta-cyclodextrin inclusion complex were evaluated in rats, showing increased plasma concentration and AUC0-t indexes, prolonged half-life time, and decreased apparent clearance. In addition, the Hyperoside inclusion complex demonstrated a superior therapeutic effect in a colitis mice model, increasing body weight, improving disease activity index, alleviating colon shortening, and showing a protective effect. This may be attributed to the complex's anti-inflammatory effect by balancing the colon's microbiota.
BIOSCIENCE REPORTS
(2023)
Article
Agriculture, Multidisciplinary
Jian-Mei Luo, Wen-Cheng Zhu, Shu-Ting Cao, Zhi-Yi Lu, Meng-Han Zhang, Bo Song, Yan-Bing Shen, Min Wang
Summary: The study enhanced the cell viability of Arthrobacter simplex in Delta(1)-dehydrogenation reaction by establishing a promoter collection, increasing expression levels, and applying directed evolution of the global transcription factor. While promoting higher production, the enhancement of enzyme activity through a stronger promoter did not have as significant positive effects on biotransformation performance as improving cell stress tolerance.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Physical
Marian Novac, Adina Magdalena Musuc, Emma Adriana Ozon, Iulian Sarbu, Mirela Adriana Mitu, Adriana Rusu, Simona Petrescu, Irina Atkinson, Daniela Gheorghe, Dumitru Lupuliasa
Summary: The study focused on the development of new orally dispersible tablets containing amlodipine inclusion complexes in cyclodextrins to improve drug solubility. Solid inclusion complexes were obtained through different methods, with lyophilization proving to be the most effective. Formulations based on silicified microcrystalline cellulose showed good flowability and compressibility, making them ideal for manufacturing orally dispersible tablets.
Article
Immunology
Tom Houben, Tulasi Yadati, Robbin de Kruijf, Marion J. J. Gijbels, Joost J. F. P. Luiken, Marc van Zandvoort, Dimitris Kapsokalyvas, Dieter Luetjohann, Marit Westerterp, Jogchum Plat, David Leake, Ronit Shiri-Sverdlov
Summary: 2-hydroxypropyl-beta-cyclodextrin is considered a novel pharmacological compound with the potential to decrease cellular cholesterol levels, but recent studies have shown that its use may lead to inflammatory responses, which are dependent on exposure time.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Stasilowicz, Natalia Rosiak, Ewa Tykarska, Maciej Kozak, Jacek Jenczyk, Piotr Szulc, Joanna Kobus-Cisowska, Kornelia Lewandowska, Anita Plazinska, Wojciech Plazinski, Judyta Cielecka-Piontek
Summary: Research shows that combining piperine with HP-β-CD significantly increases its bioavailability, permeability, and maintains its biological activity, including antioxidant potential and enzyme inhibition beneficial for inflammation and neurodegenerative changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Bingren Tian, Dan Xu, Wanrong Li, Jie Wang, Jianhua Cheng, Yumei Liu
Summary: This study aimed to investigate the regulatory and shaping effects of HBA/HP-beta-CD on the proteome of L. monocytogenes. The results showed that HBA/HP-beta-CD exhibited significant antibacterial activity against L. monocytogenes, and the changes in the proteome were mainly associated with carbohydrate metabolism, protein synthesis, cell wall composition, and cell division.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hana Lim, Soyeong Jin, Youngdo Jeong, Seong-Bo Kim, Dong-Jin Jang, Sung Tae Kim
Summary: This study investigated the effects of HP beta CD on liposomal formulations, showing that HP beta CD interacts with model drugs and lipids to accelerate drug release. The approach based on supramolecule-related interactions could provide new insights for lipid-based formulations to improve drug-release properties.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Emma Adriana Ozon, Marian Novac, Daniela Gheorghe, Adina Magdalena Musuc, Mirela Adriana Mitu, Iulian Sarbu, Valentina Anuta, Adriana Rusu, Simona Petrescu, Irina Atkinson, Dumitru Lupuliasa
Summary: The novelty of this study lies in the development of new orodispersible tablets containing nifedipine as the active ingredient. The study successfully prepared inclusion complexes of nifedipine with two derivatives of beta-cyclodextrin and analyzed their physicochemical properties. Orodispersible tablets containing the inclusion complexes were also successfully manufactured.
Article
Biochemistry & Molecular Biology
Vera A. Borzova, Andrey M. Chernikov, Valeriya V. Mikhaylova, Boris I. Kurganov
Summary: Chemical chaperones are capable of suppressing protein aggregation at different stages. This study investigates the change in aggregation kinetics of yeast alcohol dehydrogenase in the presence of 2-hydroxypropyl-beta-cyclodextrin. The results show that the addition of the chaperone alters the aggregation kinetics and the order of aggregation with respect to protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marian Novac, Adina Magdalena Musuc, Emma Adriana Ozon, Iulian Sarbu, Mirela Adriana Mitu, Adriana Rusu, Daniela Gheorghe, Simona Petrescu, Irina Atkinson, Dumitru Lupuliasa
Summary: The aim of this study was to manufacture new orally disintegrating tablets containing nimodipine-hydroxypropyl-beta-cyclodextrin and nimodipine-methyl-beta-cyclodextrin inclusion complexes. Three methods of preparation were compared, and the lyophilization method was found to be more effective. The formulation and precompression studies for the tablets containing the inclusion complexes were successfully assessed.
Article
Engineering, Chemical
Mengmeng Jia, Wen-Hai Zhang, Xuehong Zhang, Ming-Jie Yin, Shuo Gu, Xinmiao Hu, Hongxia Guo
Summary: In this work, a loose thin film composite (TFC) membrane was fabricated via interfacial polymerization, and tannic acid was added to enhance the rejection rate. The resulting membrane showed optimal permeability and high desalination efficiency for antibiotics. Moreover, the tannic acid incorporated membrane also exhibited enhanced chlorine resistance and antifouling ability, making it promising for antibiotic purification in pharmaceutical fields.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sangita Bhattacharyya, Hindole Ghosh, Obdulia Covarrubias-Zambrano, Krishan Jain, K. Venkateswara Swamy, Anup Kasi, Ameer Hamza, Shrikant Anant, Michael VanSaun, Scott J. Weir, Stefan H. Bossmann, Subhash B. Padhye, Prasad Dandawate
Summary: Pancreatic ductal adenocarcinoma (PDAC) is the leading cause of cancer-related deaths in the US. The development of novel drugs with improved delivery is crucial due to factors such as genetic mutations, drug resistance, multiple signaling pathways, cancer stem cells (CSCs), and desmoplastic stroma. Curcumin shows promise in inhibiting PDAC, but its clinical applicability is limited by poor solubility and metabolic instability. A difluorinated curcumin analog (CDF) has been developed, which selectively accumulates in the pancreas and inhibits PDAC growth. Its inclusion complex with 2-hydroxy-propyl-beta-cyclodextrin (HCD) increases water solubility and hydrolytic stability, leading to improved therapeutic efficacy against PDAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)