The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability

Biofilm infections, their resilience to therapy and innovative treatment strategies

(2013) U. Römling et al.   JOURNAL OF INTERNAL MEDICINE

Identification of Small Molecules That Antagonize Diguanylate Cyclase Enzymes To Inhibit Biofilm Formation

(2012) Karthik Sambanthamoorthy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities

(2012) Peter M. Gray et al.   CELLULAR IMMUNOLOGY

Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein–protein interaction

(2012) Samuel Steiner et al.   EMBO JOURNAL

Cyclic Diguanylate Inversely Regulates Motility and Aggregation in Clostridium difficile

(2012) E. B. Purcell et al.   JOURNAL OF BACTERIOLOGY

The FleQ protein from Pseudomonas aeruginosa functions as both a repressor and an activator to control gene expression from the pel operon promoter in response to c-di-GMP

(2012) C. Baraquet et al.   NUCLEIC ACIDS RESEARCH

The Pyrimidine Nucleotide Biosynthetic Pathway Modulates Production of Biofilm Determinants in Escherichia coli

(2012) Marco Garavaglia et al.   PLoS One

Synthase-dependent exopolysaccharide secretion in Gram-negative bacteria

(2012) J.C. Whitney et al.   TRENDS IN MICROBIOLOGY

The Pseudomonas aeruginosa sensor RetS switches Type III and Type VI secretion via c-di-GMP signalling

(2011) Joana A. Moscoso et al.   ENVIRONMENTAL MICROBIOLOGY

Concomitant Therapy with Methotrexate and Anti-TNF-α in Pediatric Patients with Refractory Crohnʼs Colitis: A Case Series

(2011) Imad Absah et al.   INFLAMMATORY BOWEL DISEASES

Output Targets and Transcriptional Regulation by a Cyclic Dimeric GMP-Responsive Circuit in the Vibrio parahaemolyticus Scr Network

(2011) R. B. R. Ferreira et al.   JOURNAL OF BACTERIOLOGY

The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia

(2011) Mustafa Fazli et al.   MOLECULAR MICROBIOLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity

(2010) Alex Boehm et al.   CELL

The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management

(2010) A. Dignass et al.   Journal of Crohns & Colitis

Interaction of the Diguanylate Cyclase YdeH of Escherichia coli with 2',(3')-Substituted Purine and Pyrimidine Nucleotides

(2010) C. Spangler et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The diguanylate cyclase YddV controls production of the exopolysaccharide poly-N-acetylglucosamine (PNAG) through regulation of the PNAG biosynthetic pgaABCD operon

(2010) L. Tagliabue et al.   MICROBIOLOGY-SGM

The c-di-GMP Binding Protein YcgR Controls Flagellar Motor Direction and Speed to Affect Chemotaxis by a “Backstop Brake” Mechanism

(2010) Koushik Paul et al.   MOLECULAR CELL

5-Fluorouracil reduces biofilm formation in Escherichia coli K-12 through global regulator AriR as an antivirulence compound

(2009) Can Attila et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors

(2009) Davide Antoniani et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Anti-adhesion activity of two biosurfactants produced by Bacillus spp. prevents biofilm formation of human bacterial pathogens

(2009) F. Rivardo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characteristics of Biofilms from Urinary Tract Catheters and Presence of Biofilm-Related Components in Escherichia coli

(2009) Xiaoda Wang et al.   CURRENT MICROBIOLOGY

The Staphylococcus aureus GGDEF Domain-Containing Protein, GdpS, Influences Protein A Gene Expression in a Cyclic Diguanylic Acid-Independent Manner

(2009) F. Shang et al.   INFECTION AND IMMUNITY

Effects of interactions of antibacterial drugs with each other and with 6-mercaptopurine on in vitro growth of Mycobacterium avium subspecies paratuberculosis

(2009) M. Y. Krishnan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli

(2009) N. Sommerfeldt et al.   MICROBIOLOGY-SGM

Mycobacterium avium subspecies paratuberculosis, Crohn's disease and the Doomsday scenario

(2009) John Hermon-Taylor   Gut Pathogens

Connecting Quorum Sensing, c-di-GMP, Pel Polysaccharide, and Biofilm Formation in Pseudomonas aeruginosa through Tyrosine Phosphatase TpbA (PA3885)

(2009) Akihiro Ueda et al.   PLoS Pathogens

A Staphylococcal GGDEF Domain Protein Regulates Biofilm Formation Independently of Cyclic Dimeric GMP

(2008) L. M. Holland et al.   JOURNAL OF BACTERIOLOGY

Distinct Sensory Pathways in Vibrio cholerae El Tor and Classical Biotypes Modulate Cyclic Dimeric GMP Levels To Control Biofilm Formation

(2008) B. K. Hammer et al.   JOURNAL OF BACTERIOLOGY

Cellulose modulates biofilm formation by counteracting curli-mediated colonization of solid surfaces in Escherichia coli

(2008) L. Gualdi et al.   MICROBIOLOGY-SGM

Identification of FleQ fromPseudomonas aeruginosaas a c-di-GMP-responsive transcription factor

(2008) Jason W. Hickman et al.   MOLECULAR MICROBIOLOGY

Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP

(2008) N. Sudarsan et al.   SCIENCE

Uracil influences quorum sensing and biofilm formation inPseudomonas aeruginosaand fluorouracil is an antagonist

(2008) Akihiro Ueda et al.   Microbial Biotechnology

Phosphorylation-Independent Regulation of the Diguanylate Cyclase WspR

(2008) Nabanita De et al.   PLOS BIOLOGY