The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis

MDR-TB Has New Drug Foe After Fast-Track Approval

(2013) Rebecca Voelker   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Thiolates Chemically Induce Redox Activation of BTZ043 and Related Potent Nitroaromatic Anti-Tuberculosis Agents

(2013) Rohit Tiwari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advances in the development of new tuberculosis drugs and treatment regimens

(2013) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of decaprenylphosphoryl-β-D-ribose 2'-epimerase fromMycobacterium smegmatis

(2013) Hua Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Approval of Novel TB Drug Celebrated--With Restraint

(2013) J. Cohen   SCIENCE

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

(2012) Sarah A. Stanley et al.   ACS Chemical Biology

Prospects for Tuberculosis Elimination

(2012) Christopher Dye et al.   Annual Review of Public Health

In VitroCombination Studies of Benzothiazinone Lead Compound BTZ043 against Mycobacterium tuberculosis

(2012) Benoit Lechartier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimycobacterial drugs currently in Phase II clinical trials and preclinical phase for tuberculosis treatment

(2012) Jean Engohang-Ndong   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Exposure of Mycobacteria to Cell Wall-inhibitory Drugs Decreases Production of Arabinoglycerolipid Related to Mycolyl-arabinogalactan-peptidoglycan Metabolism

(2012) Yoann Rombouts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors

(2012) S. M. Batt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translating basic science insight into public health action for multidrug- and extensively drug-resistant tuberculosis

(2012) NICHOLAS D. WALTER et al.   RESPIROLOGY

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

(2012) J. Neres et al.   Science Translational Medicine

Tuberculosis and HIV Co-Infection

(2012) Andrzej Pawlowski et al.   PLoS Pathogens

New tuberculosis drugs on the horizon

(2011) Stewart T Cole et al.   CURRENT OPINION IN MICROBIOLOGY

Mycobacterium tuberculosis Transmission in a Country with Low Tuberculosis Incidence: Role of Immigration and HIV Infection

(2011) L. Fenner et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1

(2011) Claudia Trefzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decaprenylphosphoryl-β-D-Ribose 2′-Epimerase, the Target of Benzothiazinones and Dinitrobenzamides, Is an Essential Enzyme in Mycobacterium smegmatis

(2011) Paul K. Crellin et al.   PLoS One

Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis

(2011) Ana Luisa de Jesus Lopes Ribeiro et al.   PLoS One

Clinical Isolates of Mycobacterium tuberculosis in Four European Hospitals Are Uniformly Susceptible to Benzothiazinones

(2010) M. R. Pasca et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 ofMycobacterium tuberculosis

(2010) Claudia Trefzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbon flux rerouting during Mycobacterium tuberculosis growth arrest

(2010) Lanbo Shi et al.   MOLECULAR MICROBIOLOGY

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

(2010) Giulia Manina et al.   MOLECULAR MICROBIOLOGY

Leads for antitubercular compounds from kinase inhibitor library screens

(2010) Sophie Magnet et al.   TUBERCULOSIS

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

(2009) V. Makarov et al.   SCIENCE

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

(2009) Thierry Christophe et al.   PLoS Pathogens

Biosynthesis of D-arabinose in mycobacteria - a novel bacterial pathway with implications for antimycobacterial therapy

(2008) Beata A. Wolucka   FEBS Journal

Structural Analysis of the Catalytic Mechanism and Stereoselectivity inStreptomyces coelicolorAlditol Oxidase†,‡

(2007) Federico Forneris et al.   BIOCHEMISTRY