期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 97, 期 8, 页码 3323-3331出版社
SPRINGER
DOI: 10.1007/s00253-013-4815-z
关键词
Hydroxy fatty acids; Microbial transformation; Catalytic mechanism; Hydroxylase; Monooxygenase
资金
- National Natural Science Foundation of China [21202179]
Hydroxy fatty acids (HFAs) are very important chemicals for versatile applications in biodegradable polymer materials and cosmetic and pharmaceutical industries. They are difficult to be synthesized via chemical routes due to the inertness of the fatty acyl chain. In contrast, these fatty acids make up a major class of natural products widespread among bacteria, yeasts, and fungi. A number of microorganisms capable of producing HFAs from fatty acids or vegetable oils have been reported. Therefore, HFAs could be produced by biotechnological strategies, especially by microbial conversion processes. Microorganisms could oxidize fatty acids either at the terminal carbon or inside the acyl chain to produce various HFAs, including alpha-HFAs, beta-HFAs, mid-position HFAs, omega-HFAs, di-HFAs, and tri-HFAs. The enzymes and their encoded genes responsible for the hydroxylation of the carbon chain have been identified and characterized during the past few years. The involved microbes and catalytic mechanisms for the production of different types of HFAs are systematically demonstrated in this review. It provides a better view of HFA biosynthesis and lays the foundation for further industrial production.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据