Article
Cell Biology
Shelby C. Inbody, Bridgett E. Sinquefield, Joshua P. Lewis, Renita E. Horton
Summary: Organs-on-chips (OOCs) are microfluidic-based devices that mimic the structure and function of organs. These systems have been successfully used in disease, development, and drug studies, offering advantages over traditional tissue culture platforms in replicating in vivo conditions. Further research is ongoing to address implementation challenges and advance the field of OOC models.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Xin Yuan Lim, Sharah Mae Capinpin, Nagarjun Bolem, Aaron Song Chuan Foo, Wai-Cheong George Yip, Alan Prem Kumar, Daniel Boon Loong Teh
Summary: Glioblastoma multiforme (GBM) is an aggressive brain tumor with limited treatment options due to the difficulty of drugs crossing the blood-brain barrier (BBB) and tumor heterogeneity. Nanoparticle (NP) drug carriers have shown promise in targeting cells beyond the BBB. This review focuses on biomimetic NPs in GBM therapy and their potential in overcoming physiological and anatomical challenges.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Xiping He, Yifan Ma, Haotian Xie, Gaofeng Rao, Zhaogang Yang, Jingjing Zhang, Zhong Feng
Summary: The discovery and clinical application of biomarkers are crucial for early cancer diagnosis and reducing mortality rates. Although nanotechnology-based bioinspired detection systems show promise, challenges like contamination and unstable signal-to-noise ratios persist. Natural materials in biological frames are inspiring researchers to develop new bioinspired and biomimetic nanostructures that can enhance detection sensitivity and specificity for effective cancer diagnosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Qing You, Fuming Liang, Gege Wu, Fangfang Cao, Jingyi Liu, Zhaohui He, Chen Wang, Ling Zhu, Xiaoyuan Chen, Yanlian Yang
Summary: Brain diseases pose a serious health threat and are often difficult to treat due to the blood-brain barrier. Biomimetic nanovesicles, a type of nanotechnology, can penetrate the blood-brain barrier and be utilized for drug delivery to the brain. This review discusses the classification and characterization of nanovesicles in various brain diseases, as well as the challenges and applications of nanotechnology-integrated nanovesicles for diagnosis and treatment.
ADVANCED MATERIALS
(2023)
Review
Virology
Shuo Li, Xue Liu, Gang Liu, Chao Liu
Summary: Over 600 million people worldwide have been infected with SARS-CoV-2, resulting in the COVID-19 pandemic. New waves of COVID-19 caused by emerging SARS-CoV-2 variants pose new health risks. Nanotechnology offers effective solutions, such as ACE2-based nanodecoys, nanobodies, nanovaccines, and drug nanocarriers. Lessons and strategies from battling SARS-CoV-2 variants may inspire nanotechnology-based strategies for future global infectious diseases and their variants.
Review
Biochemistry & Molecular Biology
Katsuhiko Ariga
Summary: Nanoarchitectonics is an emerging concept that aims to fabricate functional materials from nano-scale components by integrating nanotechnology with various disciplines such as organic chemistry and supramolecular chemistry. It provides a suitable methodology for creating highly functional systems similar to those found in biological systems. This review article summarizes the synthesis of biomimetic and biological molecules and their functional structure formation, showcasing recent examples in different areas of nanoarchitectonics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Jaligam Murali Mohan, Khairunnisa Amreen, Arshad Javed, Satish Kumar Dubey, Sanket Goel
Summary: Electrochemical sensing has significant applications in various areas and can provide rapid analysis with a disposable, reusable, and cost-effective platform by integrating miniaturized and microfluidic devices. The recent advancements include the integration of automation and Internet of Things to realize fully automated and robust electrochemical microdevices.
CURRENT OPINION IN ELECTROCHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Marcel Franco Mougenot, Vanessa Sousa Pereira, Ana Leticia Rodrigues Costa, Marcelo Lancellotti, Marimelia Aparecida Porcionatto, Juliano Coelho da Silveira, Lucimara Gaziola de la Torre
Summary: Biomimetic nanovesicles have emerged as a promising strategy for drug and gene delivery systems, combining the advantages of biological vesicles with the controllability of synthetic systems. This article focuses on tracking the research progress in biomimetic nanovesicles applied in drug and gene delivery systems, as well as vaccines applications, describing the different sources of natural vesicles, the technical perspectives on obtaining them, and the possibility of their hybridization with synthetic liposomes.
Review
Materials Science, Biomaterials
Sushmitha Nehru, Ranjita Misra, Maharshi Bhaswant
Summary: Nanotechnology has significant implications in cancer management, particularly through the use of biomimetic nanorobots. These nanorobots can be utilized for cancer prevention, diagnosis, and treatment, with the potential to minimize side effects.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Rajendran J. C. Bose, Chase W. Kessinger, Tajinder Dhammu, Toolika Singh, Miller W. Shealy, Khanh Ha, Rena Collandra, Sebastian Himbert, Fernando J. Garcia, Natalia Oleinik, Bing Xu, Maria I. Kontaridis, Maikel C. Rheinstadter, Besim Ogretmen, Donald R. Menick, Jason R. McCarthy
Summary: This study demonstrates the potential of biomimetic nanomaterials for modulating immune response and improving outcomes in heart diseases. The engineered senescent erythrocyte-derived nanotheranostics (eSENTs) showed significant uptake in immune cells and exhibited a therapeutic effect in reducing infarct size.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Rachel C. Ollier, Yuanhui Xiang, Adriana M. Yacovelli, Matthew J. Webber
Summary: Mechanoresponsiveness, including strain-stiffening and self-healing features, is vital for preventing and repairing deformation-induced damage in natural biological tissues. However, synthetic polymeric hydrogels often fail to replicate these properties. In this study, strain-stiffening behavior is achieved in fully synthetic ideal network hydrogels via dynamic-covalent boronate ester crosslinks. The mechanism underlying this unusual stiffening response is attributed to a combination of entropic and enthalpic elasticity. This work provides insights into crosslink-driven strain-stiffening in dynamic-covalent phenylboronic acid-diol hydrogels and offers a promising platform for future applications.
Article
Green & Sustainable Science & Technology
S. Aththanayaka, G. Thiripuranathar, S. Ekanayake
Summary: Traditional methods of synthesizing nanoscale materials have negative consequences, but plant-mediated synthesis provides an alternative. Plant-derived nano-composites offer advantages such as cost-effectiveness, reduced toxicity, and abundance of raw materials. They are successfully used in environmental remediation, biomedical applications, agriculture, and engineering, opening up new opportunities for innovation and commercialization.
MATERIALS TODAY SUSTAINABILITY
(2022)
Review
Pharmacology & Pharmacy
Tingting Hu, Yuezhou Huang, Jing Liu, Chao Shen, Fengbo Wu, Zhiyao He
Summary: Cancer immunotherapy holds promise for preventing tumor growth and metastasis by activating the autoimmune system. However, it is still limited by various factors such as systemic immunotoxicity, immune cell dysfunction, cancer heterogeneity, and the immunosuppressive tumor microenvironment (ITME). Biomimetic cell-derived nanoparticles have gained attention due to their improved biocompatibility and lower immunogenicity. They can achieve desired biological effects based on the specific functions of the source cells. This review highlights the latest developments in biomimetic cell-derived nanoparticles for cancer immunotherapy, discusses their applications, and analyzes the challenges for clinical translation.
Review
Engineering, Biomedical
Faisal Raza, Hajra Zafar, Shulei Zhang, Zul Kamal, Jing Su, Wei-En Yuan, Mingfeng Qiu
Summary: Immunotherapy in cancer treatment is being significantly impacted by advancements in biomimetic nanotechnology. The challenges surrounding cancer nanomedicine have led to a push for innovative approaches, such as biomimetic nanoparticles, to improve the delivery and effectiveness of immunotherapeutics for cancer. These strategies show promise in addressing issues related to the tumor microenvironment, patient heterogeneity, and immunotoxicity.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Haoyu Guo, Lutong Wang, Wei Wu, Mingke Guo, Lingkai Yang, Zhenhao Zhang, Li Cao, Feifei Pu, Xin Huang, Zengwu Shao
Summary: In this study, a nanoreactor was constructed by loading indocyanine green and tirapazamine on mesoporous polydopamine and camouflaging it with tumor cell membrane. The nanoreactor exhibited dual-targeting ability and sustained treatment for hypoxic tumors. With the activation of near-infrared laser, the nanoreactor produced cytotoxic reactive oxygen species and inhibited tumor growth by down-regulating hypoxia-inhibitory factor-1 alpha.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Dermatology
Daphne Meza, Danni Wang, Yu Wang, Sabine Borwege, Nader Sanai, Jonathan T. C. Liu
LASERS IN SURGERY AND MEDICINE
(2015)
Review
Engineering, Biomedical
Kenneth M. Tichauer, Yu Wang, Brian W. Pogue, Jonathan T. C. Liu
PHYSICS IN MEDICINE AND BIOLOGY
(2015)
Article
Biochemical Research Methods
Yu Winston Wang, Soyoung Kang, Altaz Khan, Philip Q. Bao, Jonathan T. C. Liu
BIOMEDICAL OPTICS EXPRESS
(2015)
Article
Multidisciplinary Sciences
Lagnojita Sinha, Yu Wang, Cynthia Yang, Altaz Khan, Jovan G. Brankov, Jonathan T. C. Liu, Kenneth M. Tichauer
SCIENTIFIC REPORTS
(2015)
Article
Engineering, Electrical & Electronic
Yu Wang, Soyoung Kang, Josh D. Doerksen, Adam K. Glaser, Jonathan T. C. Liu
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2016)
Article
Biochemical Research Methods
A. K. Glaser, Y. Wang, J. T. C. Liu
BIOMEDICAL OPTICS EXPRESS
(2016)
Article
Engineering, Biomedical
Xiaochun Xu, Yu Wang, Jialing Xiang, Jonathan T. C. Liu, Kenneth M. Tichauer
PHYSICS IN MEDICINE AND BIOLOGY
(2017)
Article
Engineering, Biomedical
Adam K. Glaser, Nicholas P. Reder, Ye Chen, Erin F. McCarty, Chengbo Yin, Linpeng Wei, Yu Wang, Lawrence D. True, Jonathan T. C. Liu
NATURE BIOMEDICAL ENGINEERING
(2017)
Article
Engineering, Electrical & Electronic
Aobo Li, Jun Cai, Junfeng Pan, Yu Wang, Yue Yue, Deyuan Zhang
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2014)
Article
Chemistry, Multidisciplinary
Junfeng Pan, Yu Wang, Jun Cai, Aobo Li, Hongyan Zhang, Yonggang Jiang, Deyuan Zhang
NEW JOURNAL OF CHEMISTRY
(2014)
Article
Optics
D. Wang, D. Meza, Y. Wang, L. Gao, J. T. C. Liu
Article
Biochemical Research Methods
Yu Winston Wang, Altaz Khan, Steven Y. Leigh, Danni Wang, Ye Chen, Daphne Meza, Jonathan T. C. Liu
BIOMEDICAL OPTICS EXPRESS
(2014)
Article
Multidisciplinary Sciences
Yu Wang, Soyoung Kang, Altaz Khan, Gabriel Ruttner, Steven Y. Leigh, Melissa Murray, Sanjee Abeytunge, Gary Peterson, Milind Rajadhyaksha, Suzanne Dintzis, Sara Javid, Jonathan T. C. Liu
SCIENTIFIC REPORTS
(2016)
Article
Oncology
Yu Winston Wang, Nicholas P. Reder, Soyoung Kang, Adam K. Glaser, Qian Yang, Matthew A. Wall, Sara H. Javid, Suzanne M. Dintzis, Jonathan T. C. Liu
Proceedings Paper
Optics
Danni Wang, Ye Chen, Daphne Meza, Yu Winston Wang, Jonathan T. C. Liu
TRANSLATIONAL BIOPHOTONICS
(2014)