Article
Chemistry, Medicinal
Cao Van Anh, Jong Soon Kang, Hwa-Sun Lee, Phan Thi Hoai Trinh, Chang-Su Heo, Hee Jae Shin
Summary: In this study, three new glycosylated secondary metabolites and three known compounds were isolated from two marine-derived bacterial strains. The structures of the new compounds were determined through extensive analysis and comparison of their spectroscopic data. The cytotoxicity assay showed that one of the new compounds exhibited moderate activity against multiple cancer cell lines.
Article
Biochemistry & Molecular Biology
Matteo Gaglianone, Maria Elena Laugieri, Adriana Lucely Rojas, Maria Rosaria Coppola, Francesco Piacente, Pier Luigi Fiori, Michela Giulia Tonetti
Summary: In this study, the first committed and limiting step of the L-rhamnose biosynthetic pathway in Trichomonas vaginalis was identified and characterized. The L-rhamnose synthesis in T. vaginalis proceeds through a mechanism different from typical eukaryotic pathways and involves separate enzymes for epimerase and reductase activities. Understanding the L-rhamnose biosynthetic pathway can provide insights into the formation of complex glycan structures and the development of selective inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Dragana Despotovic, Einav Aharon, Olena Trofimyuk, Artem Dubovetskyi, Kesava Phaneendra Cherukuri, Yacov Ashani, Or Eliason, Martin Sperfeld, Haim Leader, Andrea Castelli, Laura Fumagalli, Alon Savidor, Yishai Levin, Liam M. Longo, Einat Segev, Dan S. Tawfik
Summary: Anthropogenic organophosphorus compounds (AOPCs) are widely used synthetic organic phosphorus compounds. Only a few bacteria have been found to possess the key enzyme for AOPC degradation. This study reveals the utilization of diverse AOPCs by marine bacteria, indicating their capability to adapt to phosphorus limitation and pollution. The discovery offers potential for the bioremediation of anthropogenic pollutants.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Geochemistry & Geophysics
Chin Yik Lin, Harold J. Bradbury, Gilad Antler, David J. Burdige, Thomas D. Bennett, Shichun Li, Alexandra V. Turchyn
Summary: Sedimentary microbial communities play a critical role in the global carbon cycle, with the presence of clay minerals stimulating the growth of sulfate-reducing bacteria and influencing the rate of sulfate consumption in marine sediments.
EARTH AND PLANETARY SCIENCE LETTERS
(2022)
Article
Microbiology
Jaime Rosas-Diaz, Alejandra Escobar-Zepeda, Libertad Adaya, Jorge Rojas-Vargas, Diego Humberto Cuervo-Amaya, Ayixon Sanchez-Reyes, Liliana Pardo-Lopez
Summary: Paenarthrobacter sp. GOM3 is a new strain with a unique species-specific background that can grow independently in marine sediments and participate in the degradation of intermediate metabolites of aromatic compounds, showing potential for remediation of PAH-contaminated sites.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Environmental Sciences
Shuai Zhang, Yu Zhang, Yue Wang, Xingxiang Liu, Muyu Li, Hao Fang, Ming Kong
Summary: Surface runoff is a main pathway for emerging pollutants, including antibiotics, antibiotic-resistant bacteria, and antibiotic resistance genes, to enter marine sediments. This study investigates the impact of emerging pollutants on the fate of antibiotic resistance genes in marine sediments from different seas in China. The results show that antibiotic exposure generally decreases the relative abundance of most antibiotic resistance genes, but there are exceptions with increased abundance observed in certain conditions. The findings suggest that dosing with emerging pollutants does not increase antibiotic resistance gene abundance in marine sediments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Edisson Duarte-Restrepo, Katia Noguera-Oviedo, Deena Butryn, Joshua S. Wallace, Diana S. Aga, Beatriz E. Jaramillo-Colorado
Summary: Cartagena Bay is an estuarine system in the Caribbean Sea that receives fresh water from the Magdalena River, while analysis of marine sediments revealed the presence of pesticides, PBDEs, PCBs, and high concentrations of strontium. Metal concentrations in sediments near tanneries and hydrocarbon industries exceeded accepted values, posing a potential risk to marine life.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Microbiology
Liyun An, Ying-Chun Yan, Hai-Long Tian, Chang-Qiao Chi, Yong Nie, Xiao-Lei Wu
Summary: This study investigated the diversity, assembly process, and species coexistence of bacterial communities in seawater and sediment in the eastern Chinese marginal seas. The results showed that sediment had higher bacterial diversity compared to seawater, and the assembly process in sediment was less influenced by stochastic processes. Sulfate-reducing bacteria (SRB) played a key role in maintaining the stability and complexity of the bacterial network in seawater.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Engineering, Environmental
Shuai Liu, Jiaxin Cheng, Hairong You, Wei Chong, Minggang Zheng, Qinsheng Wei, Weijian Liu, Hui Chen, Xuan Li, Huan Liu
Summary: This study characterized the abundance, microbial composition, and diversity of ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB) in marine sediments from the Bohai Sea, Yellow Sea, and East China Sea. The results showed higher abundances of AOA genes compared to AOB genes, indicating a greater contribution of AOA to nitrification. Distinct distribution patterns of AOA and AOB communities were observed in sediments from the three seas, which were influenced by ammonia and nitrate content. These findings provide important insights into the nitrogen transformation in the marine ecosystem and the factors shaping the assembly of aerobic ammonium oxidizers.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Review
Chemistry, Medicinal
Giulia Greco, Valentina Pellicioni, Ivan Cruz-Chamorro, Giuseppe Attisani, Claudio Stefanelli, Carmela Fimognari
Summary: This review presents and discusses the pharmacological potential of marine-derived compounds in inhibiting topoisomerase II activity against tumors. While the existence of topoisomerase II inhibitors has been demonstrated, further research is needed to elucidate their specific mechanisms and conduct toxicological evaluations focused on cancer cell selectivity.
Article
Environmental Sciences
Samet Kalkan
Summary: This study examined the resistance levels of heterotrophic bacteria colonizing marine sediments in the Black Sea to heavy metals. The results indicate the presence of heavy metal resistant bacteria within Black Sea sediments, with Bacillus wiedmannii identified as the most resistant population.
MARINE POLLUTION BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Muddukrishnaiah Kotakonda, Makesh Marappan, Prabaharan Dharmar, Balasubramaniyan Sakthivel, Prasad Sunnapu
Summary: In this study, a facultative anaerobic strain of Bacillus subtilis (AU-RM-1) isolated from marine sediment was found to produce a bioactive secondary metabolite with antimicrobial properties. The active compound showed antimicrobial activity against clinically important microorganisms and its structure was identified using spectroscopy.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Venke Kristoffersen, Marte Jenssen, Heba Raid Jawad, Johan Isaksson, Espen H. Hansen, Teppo Rama, Kine O. Hansen, Jeanette Hammer Andersen
Summary: Through chemical studies of bacteria belonging to the Lacinutrix genus, two novel isobranched lyso-ornithine lipids were identified, with compound 1 exhibiting antibacterial activity, while compound 2 showed cytotoxic activity against human melanoma cells.
Article
Engineering, Environmental
Ranran Dong, Zhifeng Wan, Xinping Wang, Yan Bai, Mutai Bao, Haoshuai Li
Summary: Oil spills interact with mineral particles to form oil-particle aggregates (OPAs). Bacteria play a significant role in the formation and migration of OPAs, increasing particle penetration depth and changing their vertical distribution. This study provides valuable insights into the mechanisms underlying bacterial influence on OPAs and expands our understanding of marine oil spill migration.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Microbiology
Zak Kerrigan, Steven D'Hondt
Summary: This study examined the influences of OTUs and ASVs on the patterns of marine microbial diversity and community composition. OTU richness was higher than ASV richness in both water column and sediment samples. However, both methods yielded similar vertical patterns of relative diversity and community composition. The two methods also produced similar community compositions at the taxonomic levels of phyla to families.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Baoli Li, Shuaishuai Ni, Fei Mao, Feifei Chen, Yifu Liu, Hanwen Wei, Wenhua Chen, Jin Zhu, Lefu Lan, Jian Li
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Shuaishuai Ni, Hanwen Wei, Baoli Li, Feifei Chen, Yifu Liu, Wenhua Chen, Yixiang Xu, Xiaoxia Qiu, Xiaokang Li, Yanli Lu, Wenwen Liu, Linhao Hu, Dazheng Lin, Manjiong Wang, Xinyu Zheng, Fei Mao, Jin Zhu, Lefu. Lan, Jian Li
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Dongliang Guan, Feifei Chen, Faridoon, Junjie Liu, Jian Li, Lefu Lan, Wei Huang
Article
Chemistry, Medicinal
Hanwen Wei, Fei Mao, Shuaishuai Ni, Feifei Chen, Baoli Li, Xiaoxia Qiu, Linghao Hu, Manjiong Wang, Xinyu Zheng, Jin Zhu, Lefu Lan, Jian Li
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Dongliang Guan, Feifei Chen, Lun Xiong, Feng Tang, Faridoon, Yunguang Qu, Naixia Zhang, Likun Gong, Jian Li, Lefu Lan, Wei Huang
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Shuaishuai Ni, Baoli Li, Feifei Chen, Hanwen Wei, Fei Mao, Yifu Liu, Yixiang Xu, Xiaoxi Qiu, Xiaokang Li, Wenwen Liu, Linghao Hu, Dazheng Ling, Manjiong Wang, Xinyu Zheng, Jin Zhu, Lefu Lan, Jian Li
ACS MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Chemistry, Medicinal
Baoli Li, Shuaishuai Ni, Feifei Chen, Fei Mao, Hanwen Wei, Yifu Liu, Jin Zhu, Lefu Lan, Jian Li
ACS INFECTIOUS DISEASES
(2018)
Article
Chemistry, Multidisciplinary
Dongliang Guan, Feifei Chen, Yunguang Qiu, Bofeng Jiang, Likun Gong, Lefu Lan, Wei Huang
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Biochemistry & Molecular Biology
Nana Yang, Qiao Cao, Shuyang Hu, Chenchen Xu, Ke Fan, Feifei Chen, Cai-Guang Yang, Haihua Liang, Min Wu, Taeok Bae, Lefu Lan
MOLECULAR MICROBIOLOGY
(2020)
Article
Chemistry, Medicinal
Weiwei Shi, Feifei Chen, Xiangman Zou, Shang Jiao, Siqi Wang, Yu Hu, Lefu Lan, Feng Tang, Wei Huang
Summary: This study introduces a new type of antibiotic, VPCs, which show enhanced activity against vancomycin resistant bacteria and effectiveness against Gram-negative bacteria, providing a novel strategy for vancomycin modification and glycopeptide antibiotics synthesis.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Medicinal
Jian Li, Dongliang Guan, Feifei Chen, Weiwei Shi, Lefu Lan, Wei Huang
Summary: This study reported the total and semisynthesis of a series of polymyxin analogues with 2-Thr and 10-Thr modifications to investigate the structure-activity relationship. The results indicated that the replacement of 2-/10-Thr with amino acids carrying hydrophobic side chains can maintain activity against Pseudomonas aeruginosa and had varied effects on other tested Gram-negative bacteria. Additionally, aminoacetyl esterification on 2-/10-Thr achieved excellent antibacterial activity, with compound 76 showing significantly improved activity against different strains and decreased toxicity.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Yu Hu, Xiangman Zou, Weiwei Shi, Chenhui Ma, Feifei Chen, Jian Li, Shang Jiao, Guoyu Pan, Lefu Lan, Wei Huang, Feng Tang, Fan Zhang
Summary: This study presents a facile strategy for functionalization and derivatization of vancomycin's C-terminus. By introducing C-terminal hydrazide on vancomycin, the researchers successfully conjugated cysteine and cysteine containing peptides onto vancomycin C-terminus, preparing two fluorescent FITC-vancomycin with good antibacterial activity. Additionally, lipophilic structures were introduced onto vancomycin C-terminus, resulting in vancomycin derivatives that were evaluated against both Gram-positive and negative bacteria strains.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Immunology
Feifei Chen, Hongxia Di, Yanhui Wang, Chao Peng, Rongrong Chen, Huiwen Pan, Cai-Guang Yang, Haihua Liang, Lefu Lan
Summary: Phosphorylation plays an important role in modulating the activity of the transpeptidase enzyme SrtA in Staphylococcus aureus. The catalytic site residue cysteine-184 of SrtA is primarily phosphorylated by Stk1 kinase or small-molecule phosphodonor AcP. Deletion of the phosphatase gene Stp1 increases the phosphorylation level of SrtA and leads to phenotypic defects.
Article
Multidisciplinary Sciences
Yunfu Lu, Feifei Chen, Qingmin Zhao, Qiao Cao, Rongrong Chen, Huiwen Pan, Yanhui Wang, Haixin Huang, Ruimin Huang, Qian Liu, Min Li, Taeok Bae, Haihua Liang, Lefu Lan
Summary: Inhibition of TarO, the first enzyme in the wall teichoic acid biosynthetic pathway, decreases the expression of key virulence determinants in community-associated MRSA, and this effect is linked to the activation of the VraRS two-component system. The findings suggest that targeting TarO could be a potential strategy for anti-virulence therapy in MRSA infections.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Qiao Cao, Nana Yang, Yanhui Wang, Chenchen Xu, Xue Zhang, Ke Fan, Feifei Chen, Haihua Liang, Yingchao Zhang, Xin Deng, Youjun Feng, Cai-Guang Yang, Min Wu, Taeok Bae, Lefu Lan