Review
Agriculture, Dairy & Animal Science
Meng Liu, Ling Zhao, Guoxin Gong, Lei Zhang, Lei Shi, Jiefan Dai, Yanming Han, Yuanyuan Wu, Mahmoud Mohamed Khalil, Lvhui Sun
Summary: Mycotoxins, secondary metabolites of fungi, are a major concern in animal feed with adverse effects on animal health. Various strategies including physical, chemical, biological, and nutritional approaches have been developed for the decontamination and detoxification of mycotoxins. However, each strategy has its limitations. This review provides an overview of the advantages and disadvantages of different remediation strategies and updates on the research progress in controlling mycotoxins in the feed industry.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Alessandro Catellani, Francesca Ghilardelli, Erminio Trevisi, Alessio Cecchinato, Vittoria Bisutti, Francesca Fumagalli, H. V. L. N. Swamy, Yanming Han, Sandra van Kuijk, Antonio Gallo
Summary: This study aimed to evaluate a commercially available mycotoxin mitigation product on the performance of lactating dairy cows fed a Fusarium mycotoxin-contaminated diet, and the results showed that the product played a positive role in alleviating the negative effects of mycotoxins on milk yield and quality.
Review
Engineering, Chemical
Na Wu, Wen Ou, Zhidong Zhang, Yuwen Wang, Qing Xu, He Huang
Summary: Zearalenone (ZEN) is a widespread mycotoxin that contaminates crops and animal feed, causing serious health problems for livestock and humans. Biological methods, especially microbial degradation and enzyme extraction, offer promising solutions for ZEN decontamination without sacrificing nutritional quality or safety concerns.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Applied
Wesclen Vilar Nogueira, Francisco Javier Moyano, Marcelo Borges Tesser, Jaqueline Garda-Buffon
Summary: This study evaluated the potential of peroxidase from soybean meal to mitigate aflatoxin B-1 in fish feed. The results showed that a mitigation efficiency of 90% could be achieved when the enzyme activity was 0.035U/g, temperature was 32 degrees C, time was 6 hours, and humidity was 70%. This suggests that the application of peroxidase in the feed industry could be a promising tool for reducing the risk of aflatoxin contamination in fish farming.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Article
Engineering, Environmental
Jie Han, Jiao Zhang, Jun Meng, Yuanqi Cai, Mo Cheng, Siyu Wu, Zeming Li
Summary: The immobilization of Bacillus subtilis 168 on rice straw biochar (RSB) was found to be effective in removing zearalenone (ZEN) pollutants. Octadecyl trimethyl ammonium chloride-inclusion RSB showed better performances, including high ZEN detoxification rate, cells preservation, and stability of detoxification in simulated gastrointestinal environment. The study provides a potential strategy for using biochar and microorganisms as mycotoxin detoxifying agents in agricultural feed bioremediation and environmental decontamination processes.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Food Science & Technology
Debora Muratori Holanda, Sung Woo Kim
Summary: The occurrence of mycotoxins, especially aflatoxins and Fusarium toxins, poses a challenge to pig production globally. Their toxic effects impair the health and growth of pigs. Effective mycotoxin-detoxifying agents are needed to improve pig health and performance, and enhance the sustainable use of crops.
Article
Pharmacology & Pharmacy
Ming Tian, Yanzhong Feng, Xinmiao He, Dongjie Zhang, Wentao Wang, Di Liu
Summary: Mycotoxins, toxic metabolites produced by fungi, widely exist in various food and feed materials, causing poisoning events and economic losses to livestock breeders. This paper summarizes the status and causes of mycotoxin contamination in different feeds in China, highlighting the detection issues.
Article
Microbiology
Shahrbanou Hosseini, Bertram Brenig, Sunattinee Winitchakorn, Chanidapha Kanmanee, Orranee Srinual, Wanaporn Tapingkae, Kesinee Gatphayak
Summary: Toxic fungal species produce dangerous mycotoxins that can cause diseases and even death in animals and humans. Red yeast is a promising strategy to eliminate mycotoxicity and decrease the adverse effects of mycotoxins in poultry. This study investigated how red yeast supplementation affects gene expression in the liver of laying hens exposed to mycotoxins. Rating: 8/10.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Food Science & Technology
Jessica Audrey Feijo Correa, Tiago de Melo Nazareth, Giuseppe Meca, Fernando Bittencourt Luciano
Summary: This study developed a rapid and affordable bacterial screening assay for detecting ochratoxin A (OTA) degradation capability, saving costs.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Changning Yu, Quintin Litke, Qiao Li, Peng Lu, Shangxi Liu, Francis Diony, Joshua Gong, Chengbo Yang, Song Liu
Summary: Mycotoxin contamination of animal feed has detrimental effects on animal health and performance. This study demonstrates the successful encapsulation of SMBS into nanofibrous mats for targeted delivery to the small intestine of pigs and evaluates its efficacy in detoxifying DON using IPEC-J2 cells in vitro.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ying Zhang, Zishen Lin, Lixue Wang, Xiangyue Guo, Zhihui Hao, Zhen Li, Lee J. Johnston, Bing Dong
Summary: This study evaluated the cooperative interactions between activated charcoal and herb extracts, and found that the charcoal-herb extract complex (CHC) detoxified mycotoxins through the FXR/RXR-PXR pathway. CHC showed synergistic effects in promoting animal growth and improving meat quality.
Article
Food Science & Technology
Rodrigo C. Oliveira, Josefina Cortes-Eslava, Sandra Gomez-Arroyo, Magda Carvajal-Moreno
Summary: This study found that thyme, clove, and rosemary essential oils effectively inactivated AFB(1) in vitro, reducing AFB(1) products by over 80% and completely eliminating their mutagenicity. This suggests that essential oils could be a promising approach for reducing AFB(1) in the agri-food industry.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Food Science & Technology
Shao-Ji Li, Guangzhi Zhang, Bin Xue, Qiaoling Ding, Lu Han, Jian-chu Huang, Fuhai Wu, Chonggao Li, Chunmin Yang
Summary: This review summarizes the updated knowledge on the toxicity of T-2 on poultry and potential strategies for detoxification of T-2 in poultry diet. The toxic effects of T-2 on poultry include cytotoxicity, immunotoxicity, hepatotoxicity, etc. Cytotoxicity is the primary toxicity, leading to pathological changes and impaired functions of multiple organs. Protective mechanisms and detoxifying agents can alleviate the toxic effects of T-2.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Shuai Wang, Xiaolu Wang, Leena Penttinen, Huiying Luo, Yuhong Zhang, Bo Liu, Bin Yao, Nina Hakulinen, Wei Zhang, Xiaoyun Su
Summary: Patulin, a mycotoxin commonly found in foods and beverages, can be efficiently degraded by a manganese peroxidase enzyme. The enzyme was able to rapidly degrade patulin and detoxify it, making it a potential candidate for enzymatic detoxification in food and beverages.
Review
Food Science & Technology
Yan Wang, Jie Shang, Ming Cai, Yang Liu, Kai Yang
Summary: Mycotoxins, highly toxic and carcinogenic secondary metabolites produced by fungi, have adverse effects on health and economy. Non-thermal physical detoxification technologies have great potential to reduce mycotoxin impact with minimal effects on nutritional value.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Analytical
Lisa Mayerhuber, Stephan Trattner, Sebastian Luger, Gabriele Weigelhofer, Christian Hametner, Philipp Fruhmann
Summary: Novel potentiometric sensors for the detection of antipyrine and its derivatives were developed, showing analytical performance with a near Nernstian slope and detection limits in the mu M range. Solid-phase extraction was implemented to enable pre-concentration and lower detection limits for environmental monitoring, providing valuable tools for real-life applicability.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Microbiology
Widodo Widodo, Aditya Lutfe Ariani, Donny Widianto, Dietmar Haltrich
Summary: Butyric acid is known for its anticarcinogenic and antioxidative properties. Local LAB strains Lactobacillus casei AP and Lactobacillus plantarum DR131 isolated from Indonesian infants' digestive tract and indigenous fermented buffalo milk, respectively, can produce butyric acid in vitro. However, the specific genes and metabolic pathways involved in this process are still unknown. Genomic sequencing of these strains revealed similarities with other strains, but also differences in the enzymes responsible for butyric acid synthesis. These findings provide valuable insights into the use of these LAB strains as probiotics.
Article
Chemistry, Multidisciplinary
Andreas F. Geiss, Thomas M. B. Reichhart, Barbara Pejker, Esther Plattner, Peter L. Herzog, Christopher Schulz, Roland Ludwig, Alfons K. G. Felice, Dietmar Haltrich
Summary: The study aimed to improve the turnover stability of Cellobiose dehydrogenase (CDH) through high-throughput enzyme engineering, identifying two mechanisms contributing to stability and selecting 11 improved CDH variants. These engineered CDH variants hold promise for application in continuous biosensors or biofuel cells.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Physical
Markus Lunzer, Joseph S. Beckwith, Franziska Chalupa-Gantner, Arnulf Rosspeintner, Giuseppe Licari, Wolfgang Steiger, Christian Hametner, Robert Liska, Johannes Froehlich, Eric Vauthey, Aleksandr Ovsianikov, Brigitte Holzer
Summary: A series of soluble and symmetric chalcogenophenes have been designed and synthesized as potential two-photon absorption initiators. The photophysical analysis reveals their good 2PA properties, especially the strong influence of selenium on 2PA cross sections, making them promising new 2PA photoinitiators. The efficiency and spectral versatility of two selenium-containing lead compounds have been confirmed through structuring and threshold tests, showing superior reactivity and dose compared to commercial initiators.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Analytical
Sebastian Luger, Lisa Mayerhuber, Gabriele Weigelhofer, Thomas Hein, Brigitte Holzer, Christian Hametner, Philipp Fruhmann
Summary: This paper presents the development of novel ion-selective electrodes for tropane alkaloids and drugs, which could potentially enable the creation of portable sensor arrays for the quantification of a wide range of tropane alkaloids.
Article
Chemistry, Multidisciplinary
Lidiia Tsvik, Beate Steiner, Peter Herzog, Dietmar Haltrich, Leander Suetzl
Summary: The development of L-lactate biosensors has been hindered by the lack of diversity in L-lactate-oxidizing enzymes used as bioelements. This study utilized sequence information from protein databases to identify a wider range of enzymes for L-lactate oxidation. Additionally, a new class of soluble and FMN-dependent L-lactate dehydrogenases was discovered. These findings open up new possibilities for the construction of second-generation biosensors and other biotechnological applications.
Article
Biochemistry & Molecular Biology
Anja Kostelac, Leander Sutzl, Jolanta Puc, Valentina Furlanetto, Christina Divne, Dietmar Haltrich
Summary: This study reports the biochemical characterization of a pyranose oxidase (ScPOx) from Streptomyces canus. The results showed that ScPOx oxidizes monosaccharides and various C- and O-glycosides, and belongs to the same sequence space as the recently discovered FAD-dependent C-glycoside 3-oxidase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Christiane Gruber-Dorninger, Manuela Killinger, Andreas Hobartner-Gussl, Roy Rosen, Barbara Doupovec, Markus Aleschko, Heidi Schwartz-Zimmermann, Oliver Greitbauer, Zoran Markovic, Marko Stankovic, Karin Schondorfer, Djuro Vukmirovic, Silvia Wein, Dian Schatzmayr
Summary: The estrogenic mycotoxin ZEN is commonly found in animal feed and effective strategies for its inactivation are needed. In this study, ZenA, a ZEN-degrading enzyme, was added to the feed of chickens, pigs, and rainbow trout to degrade ZEN in their gastrointestinal tracts. The results showed that ZenA effectively reduced ZEN concentration and increased the degradation product HZEN, indicating its potential as a ZEN-degrading feed additive for these animal species.
Article
Food Science & Technology
Josiane C. C. Panisson, Michael O. O. Wellington, Michael A. A. Bosompem, Veronika Nagl, Heidi E. E. Schwartz-Zimmermann, Daniel A. A. Columbus
Summary: Pigs' health and growth performance are negatively affected by exposure to deoxynivalenol (DON). The measurement of DON in feed and diets is inconsistent due to the uneven distribution of mycotoxins and difficulties in obtaining representative samples. However, this study found that analyzing DON levels in urine and blood serum can be used to predict a pig's DON intake, as there is a positive correlation between DON intake and urinary and serum DON concentrations when samples are collected under controlled conditions.
Article
Biochemistry & Molecular Biology
Barbara U. U. Metzler-Zebeli, Frederike Lerch, Fitra Yosi, Julia C. C. Votterl, Simone Koger, Markus Aigensberger, Patrick M. M. Rennhofer, Franz Berthiller, Heidi E. E. Schwartz-Zimmermann
Summary: Data on the evolution of blood metabolites and metabolic markers in neonatal piglets are scarce. This study aimed to characterize the changes in plasma metabolome and serum biochemistry of suckling and newly weaned piglets and assess metabolite patterns as physiological markers for the two phases. The results showed that plasma triglycerides were discriminative for age and nutrition in the suckling phase, while metabolites belonging to pathways within histidine, D-glutamine, and D-glutamate metabolism as well as hippuric acid were distinctive for the postweaning period.
Article
Infectious Diseases
Sineenat Sripattanakul, Teerasak Prapong, Attapon Kamlangdee, Gerd Katzenmeier, Dietmar Haltrich, Ratchanee Hongprayoon, Siriwan Prapong
Summary: Researchers have developed an indirect ELISA assay for the diagnosis of canine leptospiral infections using peptides derived from a recombinant LRR protein of Leptospira. The study showed that four peptides had high specificity and sensitivity, making them suitable for detection of antibodies against Leptospira in Thai dogs.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Infectious Diseases
Sineenat Sripattanakul, Kanpapat Boonchuay, Teerasak Prapong, Worawidh Wajjwalku, Gerd Katzenmeier, Dietmar Haltrich, Ratchanee Hongprayoon, Siriwan Prapong
Summary: The lateral flow strip test using the rhKU_Sej_LRR_2271 protein demonstrated good potential in detecting anti-leptospiral IgG in dogs, with a significant association with LipL32 ELISA. However, its sensitivity, specificity, and accuracy were relatively low.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Biochemical Research Methods
Dimitrios J. Floros, Kangkang Xu, Franz Berthiller, Heidi Schwartz-Zimmermann
Summary: Metabolomics is gaining popularity in livestock research, and this study compared different chromatographic methods to assess their coverage of mammalian metabolites. The study investigated 354 primary metabolites from various compound classes and optimized selected reaction monitoring transitions on a mass spectrometer. The results showed that hydrophilic interaction liquid chromatography (HILIC) methods had the highest coverage of metabolites, including polar ones such as amino acids and biogenic amines. Combining complementary HILIC and reversed-phase (RP) methods increased the coverage to 92%, and further incorporating anion exchange chromatography (AIC) achieved a coverage of 97%.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemistry & Molecular Biology
Phitsanu Pinmanee, Kamonwan Sompinit, Angkana Jantimaporn, Mattaka Khongkow, Dietmar Haltrich, Thidarat Nimchua, Prakit Sukyai
Summary: This study purified SOD from Saccharomyces cerevisiae TBRC657, resulting in purified Mn-SOD with a molecular weight of 25 kDa. The purified SOD showed optimal activity at pH 7.0 and 35°C, but had poor stability under high temperatures. However, when immobilized on BC, the stability was enhanced. Immobilized SOD demonstrated the ability to regulate ROS levels inside cells, making it a promising candidate for antioxidant applications in various industries.
Review
Food Science & Technology
Sudarma Dita Wijayanti, Lidiia Tsvik, Dietmar Haltrich
Summary: Food analysis and control are crucial for ensuring the quality and safety of food products. Electrochemical biosensors based on enzymes offer high selectivity, sensitivity, short analysis time, and cost-effectiveness, making them promising tools for food analysis.