Article
Engineering, Environmental
Caihong Yang, Xiaoya Ding, Chaoyu Yang, Luoran Shang, Yuanjin Zhao
Summary: In this study, marine polymer composite microcapsules were prepared using microfluidic electrospray for wound healing. The microcapsules, composed of an alginate (ALG) core and a chitosan (CS) shell, showed excellent biocompatibility and antibacterial capacity. Vascular endothelial growth factor (VEGF) could also be loaded and sustainably released from the microcapsules. The microcapsules demonstrated their potential clinical applications by inhibiting bacterial growth and promoting angiogenesis during wound closure.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Review
Polymer Science
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy Chistyakov
Summary: This review examines the use of dressings containing nanoparticles for wound repair and evaluates their antimicrobial effects and healing actions. The analysis of 31 sources published between 2021 and 2022 demonstrates a trend towards the development of modern antibacterial wound-healing nanomaterials.
Article
Nanoscience & Nanotechnology
Akhilesh Rai, Rafaela Ferrao, Denise Marta, Andreia Vilaca, Miguel Lino, Tiago Rondao, Jian Ji, Artur Paiva, Lino Ferreira
Summary: Currently, there is a lack of effective therapeutic dressings in the market that can prevent bacterial infection and promote skin regeneration in diabetic patients. A study has evaluated the antimicrobial and pro-regenerative effect of LL37 peptide immobilized in polyurethane-based wound dressings. The results showed that the LL37 peptide dressing effectively killed bacteria without inducing resistance and accelerated wound healing and re-epithelialization in diabetic mice.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Jie Yu, Ruili Zhang, Baihang Chen, Xuelan Liu, Qian Jia, Xiaofei Wang, Zuo Yang, Pengbo Ning, Zhongliang Wang, Yang Yang
Summary: This study establishes a system consisting of a degradable hydrogel dressing that reacts to reactive oxygen species, an encapsulated biosafe nitric oxide donor, and a low concentration of hydrogen peroxide as a disinfectant. This system promotes sustainable wound healing and disinfection by generating nitric oxide and mediating cell migration and collagen synthesis. It also demonstrates synergistic antibacterial properties against antibiotic-resistant bacteria.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Medicine, Research & Experimental
Yue Liang, Min Li, Yuan Tang, Jinlong Yang, Jing Wang, Yuqi Zhu, Huitong Liang, Qinru Lin, Yipen Cheng, Xinyi Yang, Huanzhang Zhu
Summary: A thermosensitive composite hydrogel loaded with nicotinamide mononucleotide (NMN) was synthesized, which effectively promoted diabetic wound healing by inhibiting oxidative stress reactions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Physical
Nhien Nguyen, Zong-Hong Lin, Snigdha Roy Barman, Chiranjeevi Korupalli, Ji-Yen Cheng, Ni-Xuan Song, Yen Chang, Fwu-Long Mi, Hsiang-Lin Song, Hsing-Wen Sung, Yu-Jung Lin
Summary: This study developed an engineered electroactive dressing that promotes wound healing and monitors the progress in real-time. The dressing transmits bioelectrical signals to stimulate cells and accelerate tissue restoration, while an electrode detects electrical resistance or output current to monitor the overall healing process. The system can be connected to a smartphone for wireless data transmission to medical staff and provide early warnings of potential infections.
Article
Engineering, Biomedical
Lipeng Qiao, Yongping Liang, Jueying Chen, Ying Huang, Saeed A. Alsareii, Abdulrahman Manaa Alamri, Farid A. Harraz, Baolin Guo
Summary: In this study, adhesive self-healing conductive antibacterial hydrogel dressings were prepared for the repair of infected wounds. The hydrogel exhibited self-healing properties, good conductivity, photothermal anti-bacterial properties, and improved wound healing in the infected skin wound repair test. These hydrogels have potential as promising candidates for wound healing dressings for the treatment of infected skin wounds.
BIOACTIVE MATERIALS
(2023)
Article
Dermatology
Klaus Kirketerp-Moller, Petra Doerfler, Nicole Schoefmann, Barbara Wolf-Winiski, Omid Niazi, Vibeke Pless, Tonny Karlsmark, Magnus Agren
Summary: This exploratory study aimed to investigate the association between biomarkers in wound fluid and the healing of split-thickness skin grafts in venous leg ulcers. The study found that the concentration of matrix metalloproteinase-9 in wound fluid was higher in venous leg ulcers showing good healing compared to those with poor healing.
ACTA DERMATO-VENEREOLOGICA
(2022)
Review
Chemistry, Multidisciplinary
Ilenia De Luca, Parisa Pedram, Arash Moeini, Pierfrancesco Cerruti, Gianfranco Peluso, Anna Di Salle, Natalie Germann
Summary: Wound healing is a complex cellular process, and traditional wound dressing materials may not be sufficient to support this process. Nanotechnology can provide the necessary properties, while natural biopolymers such as alginate and chitosan show potential antibacterial and anti-inflammatory effects, which are beneficial for promoting the healing process.
APPLIED SCIENCES-BASEL
(2021)
Article
Materials Science, Multidisciplinary
Ji-Hwan Ha, Jae Yun Kim, Dahong Kim, Junseong Ahn, Yongrok Jeong, Jiwoo Ko, Soonhyoung Hwang, Sohee Jeon, Young Jung, Jimin Gu, Hyeonseok Han, Jungrak Choi, Gihun Lee, Moonjeong Bok, Su A. Park, Yee Sook Cho, Jun-Ho Jeong, Inkyu Park
Summary: This study develops an electrospun composite micro/nanofiber-based bilayer-dressing patch with a healing-support layer and a protective/monitoring layer. The healing-support layer enhances cell regeneration and biocompatibility for rapid healing. The protective/monitoring layer exhibits excellent antimicrobial properties and visible color changes within the pH range of wound lesions, suitable for advanced wound care. Wounds on BALB/c mice heal rapidly in 12 days, and the wound state can be diagnosed by the color change of the dressing patch. This multifunctional wound dressing patch promotes wound healing and facilitates convenient wound management.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Huifeng Dong, Liangyu Wang, Lin Du, Xing Wang, Qin Li, Xiaoyue Wang, Jie Zhang, Jun Nie, Guiping Ma
Summary: Developing a multifunctional hydrogel dressing that can adapt to complex and changeable environments, reconstruct skin sensory functions, and provide continuous bactericidal activity is challenging. In this study, a hydrogel dressing based on alginate and polycation was developed, which showed excellent antibacterial properties and accelerated wound healing in a rat model. The hydrogel also demonstrated multiple response modes for strain, pressure, and temperature sensing, providing a smart solution for wound healing and human health monitoring.
Article
Materials Science, Biomaterials
Zhaoyang Guo, Haiyang Liu, Zhekun Shi, Lulu Lin, Yinping Li, Miao Wang, Guoqing Pan, Yifeng Lei, Longjian Xue
Summary: In this study, a glucose-responsive insulin-releasing hydrogel microneedle dressing was developed for diabetic wound healing. The microneedle dressing exhibited mechanical stability, biocompatibility, glucose-responsive insulin release, and improved blood glucose control, making it effective for diabetic wound management and potentially useful for other chronic skin injuries.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Jianmin Yang, Yufeng Huang, Jiajia Dai, Xianai Shi, Yunquan Zheng
Summary: A sandwich structure composite wound dressing with long-term antimicrobial activity and wound healing promotion was developed and demonstrated superior wound healing effect on deep dermal burns in a porcine model. It has great potential application in severe wound care.
REGENERATIVE BIOMATERIALS
(2021)
Article
Biophysics
Yanwei Li, Tangfeng Wu, Guozheng Zhang, Ai Fang, Yurong Li, Susu Wang, Hui Yan, Peisheng Liang, Jialin Lian, Yeshun Zhang
Summary: In this study, a novel bioactive dressing based on native nondestructive sericin was developed. The dressing was directly secreted by silkworms through regulating their spinning behaviors. It possessed natural structures and bioactivities, as well as a porous fibrous network structure with high air permeability. Furthermore, the dressing showed pH-responsive degradability, softness, super absorbency, and high mechanical strength. It also supported cell viability, proliferation, and migration, and significantly accelerated the healing process in a mouse full-thickness skin wound model. These findings suggest that the sericin wound dressing has promising application and commercial value in wound repair.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)