Article
Microbiology
Connie F. Canete-Gibas, James Mele, Hoja P. Patterson, Carmita J. Sanders, Dora Ferrer, Victor Garcia, Hongxin Fan, Marjorie David, Nathan P. Wiederhold
Summary: Dermatophytes are common pathogens causing skin, hair, and nail infections in humans. A study evaluated the antifungal susceptibility profiles and species identification of dermatophytes received from North America, revealing relatively common terbinafine resistance and the presence of Trichophyton indotineae in multiple areas. Continued surveillance is necessary.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Dermatology
Junichiro Hiruma, Hiromitsu Noguchi, Midori Hase, Yumie Tokuhisa, Tatsuya Shimizu, Takasuke Ogawa, Masataro Hiruma, Kazutoshi Harada, Rui Kano
Summary: Research investigated TRF-resistant Trichophyton interdigitale and T. rubrum strains isolated from Japanese patients, identifying some TRF-resistant strains and revealing genetic mutations in these strains.
JOURNAL OF DERMATOLOGY
(2021)
Article
Plant Sciences
Adriana Trifan, Andra-Cristina Bostanaru, Simon Vlad Luca, Veronika Temml, Muhammad Akram, Sonja Herdlinger, Lukasz Kulinowski, Krystyna Skalicka-Wozniak, Sebastian Granica, Monika E. Czerwinska, Aleksandra Kruk, Helene Greige-Gerges, Mihai Mares, Daniela Schuster
Summary: This study found that honokiol and magnolol have high activity against dermatophyte infections, acting as fungicidal agents through inhibition of ergosterol biosynthesis. Synergistic effects were observed when magnolol was combined with terbinafine, while honokiol only showed additive effects. Additionally, magnolol displayed inhibitory effects on pro-inflammatory cytokines released by stimulated human neutrophils.
Article
Polymer Science
Muhammad Abdullah Akram, Barkat Ali Khan, Muhammad Khalid Khan, Ali Alqahtani, Sultan M. Alshahrani, Khaled M. Hosny
Summary: The study successfully developed a polymeric emulgel of eugenol and linalool for the treatment of Trichophyton rubrum infections. The emulgel showed good physical properties and demonstrated significant effects in treating the infections both in vitro and in vivo, making it a promising topical treatment option.
Article
Microbiology
Anne-Laure Bidaud, Patrick Schwarz, Anuradha Chowdhary, Eric Dannaoui
Summary: A combination of terbinafine with itraconazole was found to have synergistic effects against both terbinafine-susceptible and terbinafine-resistant isolates of Trichophyton spp. from India.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Infectious Diseases
Huilin Su, Weiwei Jiang, Paul E. Verweij, Li Li, Junhao Zhu, Jiande Han, Min Zhu, Shuwen Deng
Summary: The emergence of resistance in Trichophyton rubrum to azoles and terbinafine has led to the need for the development of new antifungal drugs. In this study, the in vitro antifungal activity of 3 echinocandins against clinical isolates of T. rubrum was evaluated. The results showed that micafungin and anidulafungin exhibited greater potency than caspofungin, suggesting that echinocandins could be potential treatment options for managing recalcitrant dermatophytoses resulting from resistance.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Karen Marie Thyssen Astvad, Rasmus Kroger Hare, Karin Meinike Jorgensen, Ditte Marie Lindhardt Saunte, Philip Kjettinge Thomsen, Maiken Cavling Arendrup
Summary: Terbinafine resistance in Trichophyton species is increasing in Denmark, with a high prevalence of non-wildtype isolates and known/novel SQLE mutations. T. rubrum is the most common species, but T. mentagrophytes/interdigitale SC isolates also contribute to resistance. Population-based studies and susceptibility testing are important for understanding and addressing this emerging problem.
Article
Microbiology
Maria Siopi, Ioanna Efstathiou, Konstantinos Theodoropoulos, Spyros Pournaras, Joseph Meletiadis
Summary: The study investigated the molecular epidemiology and in vitro antifungal susceptibility patterns of Greek Trichophyton isolates over the last 10 years using the new EUCAST reference method. It was found that a high incidence of terbinafine non-WT T. mentagrophytes isolates without cross-resistance to other antifungals was discovered for the first time in Greece. This highlights the need for susceptibility testing of dermatophytes at a local scale, especially in cases of non-responding dermatophytoses.
Article
Microbiology
Anne-Laure Bidaud, Alicia Moreno-Sabater, Anne-Cecile Normand, Genevieve Cremer, Francoise Foulet, Sophie Brun, Aymen Ayachi, Sebastien Imbert, Anuradha Chowdhary, Eric Dannaoui
Summary: The number of dermatophytosis cases resistant to terbinafine is increasing globally, highlighting the importance of antifungal susceptibility testing for better patient management. A gradient test (GT) method was evaluated for testing the susceptibility of dermatophytes to terbinafine. The MIC values determined by the GT method were lower than the EUCAST reference technique, indicating its potential as a reliable alternative.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Mycology
Rui Kano, Honoka Nojo, Hiromitsu Noguchi
Summary: In this study, the researchers induced terbinafine resistance in a T. rubrum strain and compared the genomes of the resistant and susceptible strains. They found that the only variation associated with drug resistance in the resistant strain was a hotspot mutation in the SQLE gene.
Article
Microbiology
Rui Kano, Utako Kimura, Hiromitsu Noguchi, Masataro Hiruma
Summary: The multi-antifungal drug-resistant strain (NUBS21012) of Trichophyton rubrum, isolated from a patient with recurrent tinea corporis, showed an increased expression of genes encoding ATP-binding cassette transporter proteins. This suggests a close association between ATP-binding cassette transporter proteins and azole resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Nicole L. van der Weerden, Kathy Parisi, James A. Mckenna, Brigitte M. Hayes, Peta J. Harvey, Pedro Quimbar, Sean R. Wevrett, Prem K. Veneer, Owen Mccorkelle, Shaily Vasa, Rosemary Guarino, Simon Poon, Yolanda M. Gaspar, Michael J. Baker, David J. Craik, Rob B. Turner, Marc B. Brown, Mark R. Bleackley, Marilyn A. Anderson
Summary: Onychomycosis, or fungal nail infection, can cause pain, discomfort, and psychological and social consequences. Current treatments are limited by poor nail penetration or potential toxicity. Plant defensins, such as Ppdef1, have stable structures and potent antifungal activity, making them promising treatments. Ppdef1 shows excellent activity against a range of fungal pathogens, including Trichophyton rubrum, the major cause of onychomycosis.
Article
Dermatology
Aditya K. Gupta, Helen J. Renaud, Emma M. Quinlan, Neil H. Shear, Vincent Piguet
Summary: Superficial mycoses are increasingly developing resistance to current antifungal medications, particularly to terbinafine. Mix infections and single-point mutations are major factors contributing to this resistance.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2021)
Article
Immunology
Caroline Barcelos Costa-Orlandi, Luis R. Martinez, Niura Madalena Bila, Joel M. Friedman, Adam J. Friedman, Maria Jose S. Mendes-Giannini, Joshua D. Nosanchuk
Summary: This study evaluated the anti-T. rubrum biofilm potential of NO-np and compared it to commonly used antifungal drugs. The results showed that NO-np and efinaconazole severely damaged established biofilms, reducing the density and thickness of the biofilms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Leonardo Martins-Santana, Monise Fazolin Petrucelli, Pablo R. Sanches, Nilce M. Martinez-Rossi, Antonio Rossi
Summary: The study reveals the importance of alternative splicing in generating isoforms of virulence factors in Trichophyton rubrum, a common causative agent of dermatophytosis. The transcription factor StuA plays a crucial role in coordinating the expression of peptidase genes through alternative splicing in the presence of keratin. These findings shed light on the physiological adaptations of fungal cells and the regulation of virulence traits in dermatophyte infections.
FRONTIERS IN MICROBIOLOGY
(2022)
