期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 82, 期 6, 页码 1097-1103出版社
SPRINGER
DOI: 10.1007/s00253-008-1839-x
关键词
Antimicrobial peptides; Design; Structure parameters; Computer-aided method
资金
- National Natural Science Foundation of China [30771574, 30810303084]
- Beijing Natural Science Foundation [415062031]
- Chinese 863 Program [2004AA246040]
The increasing problem of antibiotic resistance among pathogenic bacteria requires development of new antimicrobial agents. The pivotal assets of the antimicrobial peptide include potential for rapid bactericidal activity and low propensity for resistance. The four new antimicrobial hybrid peptides were designed based on peptides LFB15 (W4,10), HP(2-20), and cecropin A according to the structure-activity relationship of the amphipathic and cationic antimicrobial peptides. Their structural parameters were accessed by bioinformatics tools, and then two hybrids with the most potential candidates were synthesized. The hybrid peptide LH28 caused an increase in antibiotic activity (MIC50 = 1.56-3.13 mu M) against given bacterial strains and did not cause obvious hemolysis of rabbit erythrocytes at concentration of 3.13 mu M with effective antimicrobial activity. The results demonstrate that evaluating the structural parameters could be useful for designing novel antimicrobial peptides.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据