Antibody promiscuity: Understanding the paradigm shift in antigen recognition

Canonical structures of short CDR-L3 in antibodies

(2014) Alexey Teplyakov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural Evaluation of a Mimicry-Recognizing Paratope: Plasticity in Antigen-Antibody Interactions Manifests in Molecular Mimicry

(2013) S. Tapryal et al.   JOURNAL OF IMMUNOLOGY

SAbDab: the structural antibody database

(2013) James Dunbar et al.   NUCLEIC ACIDS RESEARCH

Structural Elucidation of the Mechanistic Basis of Degeneracy in the Primary Humoral Response

(2012) T. Khan et al.   JOURNAL OF IMMUNOLOGY

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody

(2012) A. G. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Structural Consensus among Antibodies Defines the Antigen Binding Site

(2012) Vered Kunik et al.   PLoS Computational Biology

Structure-guided Alterations of the gp41-directed HIV-1 Broadly Neutralizing Antibody 2F5 Reveal New Properties Regarding its Neutralizing Function

(2012) Javier Guenaga et al.   PLoS Pathogens

Structural insights into parallel strategies for germline antibody recognition of lipopolysaccharide from Chlamydia

(2011) D. W. Evans et al.   GLYCOBIOLOGY

Structure-Guided Design of Antibodies

(2010) Justin A. Caravella et al.   Current Computer-Aided Drug Design

Molecular Description of Flexibility in an Antibody Combining Site

(2010) Jörg Zimmermann et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Very Few Substitutions in a Germ Line Antibody Are Required To Initiate Significant Domain Exchange

(2010) Michael Huber et al.   JOURNAL OF VIROLOGY

Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications

(2009) S. Bryson et al.   JOURNAL OF VIROLOGY

Structural Basis of the Cross-Reactivity of Genetically Related Human Anti-HIV-1 mAbs: Implications for Design of V3-Based Immunogens

(2009) Valicia Burke et al.   STRUCTURE

Exploring the Energy Landscape of Antibody−Antigen Complexes: Protein Dynamics, Flexibility, and Molecular Recognition

(2008) Megan C. Thielges et al.   BIOCHEMISTRY

A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120

(2008) Alfredo Menendez et al.   FASEB JOURNAL

Exploration of Specificity in Germline Monoclonal Antibody Recognition of a Range of Natural and Synthetic Epitopes

(2008) Cory L. Brooks et al.   JOURNAL OF MOLECULAR BIOLOGY

Design and Expression of a Dimeric Form of Human Immunodeficiency Virus Type 1 Antibody 2G12 with Increased Neutralization Potency

(2008) A. P. West et al.   JOURNAL OF VIROLOGY

Multi-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibility

(2008) Mariana Babor et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Role of Antibody Paratope Conformational Flexibility in the Manifestation of Molecular Mimicry

(2007) Lavanya Krishnan et al.   BIOPHYSICAL JOURNAL

The specificity of cross-reactivity: Promiscuous antibody binding involves specific hydrogen bonds rather than nonspecific hydrophobic stickiness

(2003) Leo C. James et al.   PROTEIN SCIENCE