期刊
IUBMB LIFE
卷 67, 期 3, 页码 160-169出版社
WILEY
DOI: 10.1002/iub.1363
关键词
protein synthesis; initiation; mRNA structure; bulged-out region of RNA; eIF5A; hypusine
资金
- Ministry of Education, Science, Sports and Culture, Japan
Polyamines are ubiquitous small basic molecules that play important roles in cell growth and viability. Since polyamines mainly exist as a polyamine-RNA complex, we looked for proteins whose synthesis is preferentially stimulated by polyamines at the level of translation, and thus far identified 17 proteins in Escherichia coli and 6 proteins in eukaryotes. The mechanisms of polyamine stimulation of synthesis of these proteins were investigated. In addition, the role of eIF5A, containing hypusine formed from spermidine, on protein synthesis is described. These results clearly indicate that polyamines and eIF5A contribute to cell growth and viability through modulation of protein synthesis. (c) 2015 IUBMB Life, 67(3):160-169, 2015
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