Article
Immunology
Wenbo Zhao, Xiaozhen He, Ruiling Liu, Qingguo Ruan
Summary: Studies have shown that inflammation delays corneal wound healing and that c-Rel, expressed by immune cells, promotes the expression of inflammatory cytokines. In this study, the researchers found that c-Rel and its inflammatory targets are significantly increased in corneas with injury. They also discovered that c-Rel-deficient mice have accelerated wound healing and reduced expression of inflammatory cytokines. Additionally, treatment with nano-polymers or exosomes loaded with c-Rel-specific siRNA effectively promoted corneal wound healing.
INFLAMMATION AND REGENERATION
(2023)
Article
Chemistry, Medicinal
Jianying Song, Jing Zeng, Silin Zheng, Nan Jiang, Anguo Wu, Shengming Guo, Rupei Ye, Lixin Hu, Feihong Huang, Long Wang, Xiaogang Zhou, Bo Liu, Jianming Wu, Qi Chen
Summary: Sanguisorba officinalis L. ethanol extract (ESO) can accelerate the healing process of diabetic wounds (DW) by suppressing the inflammatory response and increasing the ratio of M2 to M1 polarization.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, General & Internal
Annika Mohr, Manuela Besser, Sonja Broichhausen, Maximiliane Winter, Alexander D. Bungert, Benjamin Struecker, Mazen A. Juratli, Andreas Pascher, Felix Becker
Summary: There is compelling evidence indicating the important role of macrophages in intestinal wound healing. Macrophages can aggravate or attenuate the healing process due to their plasticity and heterogeneity. Impaired mucosal healing in inflammatory bowel disease (IBD) has been linked to defects in pro-resolving macrophage polarization. Apremilast, a phosphodiesterase-4 inhibitor, has gained attention as a potential IBD drug by targeting the switch from M1 to M2 macrophages.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Abhirup Shaw, Beata B. Toth, Robert Kiraly, Rini Arianti, Istvan Csomos, Szilard Poliska, Attila Vamos, Ilma R. Korponay-Szabo, Zsolt Bacso, Ferenc Gyory, Laszlo Fesues, Endre Kristof
Summary: Recent studies have shown that irisin can stimulate the release of a novel adipokine, CXCL1, from neck area derived adipocytes via upregulation of the NF kappa B pathway, potentially playing an important role in improving tissue vascularization.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jian Xie, Xiaowei Wu, Shang Zheng, Kaili Lin, Jiansheng Su
Summary: Delayed wound healing is a challenge, and this study demonstrates that aligned electrospun nanofibers can promote wound healing by influencing macrophage morphology and phenotype, as well as alleviate the local inflammatory response and promote angiogenesis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Weibei Sheng, Haotian Qin, Tiehua Wang, Jin Zhao, Chongzhou Fang, Peng Zhang, Peng Liu, Anjaneyulu Udduttula, Hui Zeng, Yingqi Chen
Summary: In this study, a water-soluble phosphocreatine-grafted methacryloyl chitosan hydrogel was synthesized and investigated for its microstructure, water absorption, and mechanical properties. The hydrogel showed a porous structure and higher water absorption rate compared to the control group. It inhibited the expression of inflammatory factors and promoted wound healing in mice.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bingyu Shen, Haoqing Zhang, Zhengjin Zhu, Zixi Ling, Fangyuan Zeng, Yazhou Wang, Jianguo Wang
Summary: Baicalin, extracted from Scutellaria, has anti-inflammatory effects and can reduce pulmonary edema caused by ALI. It inhibits the expression of TLR4 and MyD88, leading to a decrease in inflammatory molecules. Baicalin also promotes an increase in white blood cells and improves lung pathology, indicating its potential as a treatment for ALI.
Article
Chemistry, Multidisciplinary
Chun-mei Wu, Jia-wen Mao, Jin-zhi Zhu, Can-can Xie, Jia-ying Yao, Xiao-qian Yang, Mai Xiang, Yi-fan He, Xiao Tong, Dilinaer Litifu, Xiao-yu Xiong, Meng-nan Cheng, Feng-hua Zhu, Shi-jun He, Ze-min Lin, Jian-ping Zuo
Summary: The SAHH inhibitor DZ2002 has shown therapeutic potential in rodent models of DED by reducing corneal neovascularization and opacity, alleviating conjunctival irritation, and inhibiting the activation of the STAT3-PI3K-Akt-NF-kappa B pathways. It also exhibits anti-proliferative and anti-migratory effects on HUVECs.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Wuquan Li, Wentao Zhang, Jun Liu, Yalong Han, He Jiang, Gang Ji, Wenjun Liu
Summary: The study identified that down-regulation of miRNA let-7e attenuated LPS-induced acute lung injury in mice, improved survival rate, and reduced proinflammatory cytokines levels in bronchoalveolar lavage fluid. Let-7e exerts its protective effects through regulation of SOCS1/NF-kappa B pathway, suggesting it as a potential therapeutic target for ALI.
BIOSCIENCE REPORTS
(2021)
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Article
Environmental Sciences
Ping Zhang, Yandi Li, Wenping Xu, Jiagao Cheng, Cheng Zhang, Jufang Gao, Zhong Li, Liming Tao, Yang Zhang
Summary: Ivermectin is widely used as a biopesticide in animal husbandry and agriculture, but its immunotoxicity has received little attention. Research shows that Ivermectin can induce immunotoxicity through the induction of cytotoxicity and immune dysfunction.
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Aljohara M. Al-Otaibi, Asma S. Al-Gebaly, Rafa Almeer, Gadah Albasher, Wedad S. Al-Qahtani, Ahmed E. Abdel Moneim
Summary: The study found that pre-treatment of BMSCs with MEL significantly promotes wound healing in skin wounds, reduces inflammation, and exhibits anti-scarring properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Huey Xhin Teh, Shou Jin Phang, Mee Lee Looi, Umah Rani Kuppusamy, Bavani Arumugam
Summary: This review discusses the inflammatory response and potential therapeutic targets in diabetic wound healing. The abnormal activation of macrophage innate immune signaling leads to the occurrence of inflammation, and NF-κB and NLRP3 pathways may be involved. Understanding the molecular mechanisms of these pathways could be beneficial in designing potential therapeutic targets for diabetic wound healing.
Article
Integrative & Complementary Medicine
Jianxia Wen, Zhuo Xu, Xiao Ma, Yanling Zhao
Summary: This study found that Dracontomelon dao plays an important role in the antimicrobial, anti-inflammatory, and proangiogenesis activities on the skin of rats under simulated space environment. It can reduce the size and increase the shrinkage rate of wounds, alleviate histological damage of skin tissue, and downregulate inflammatory cytokines level. Furthermore, Dracontomelon dao regulates MAPK/NF-kappa B and PI3K/AKT signaling pathways.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Medicine, General & Internal
Mi Zhou, Duo Huang, Yangyang Cheng, Yee Man Lau, Wing Hon Lai, Yuk-Ming Lau, JoJo Hai, Chu Pak Lau, Esther W. Chan, Wen Sheng Yue, Ming-Liang Zuo, Li Xue Yin, Yingqing Feng, Ning Tan, Jiyan Chen, Xin Li Li, Hung Fat Tse, Chi Ho Lee, Wing-Sun Chow, Chung Wah Siu, Chun Ka Wong
Summary: This study implemented screening for left ventricular dysfunction in patients with type 2 diabetes mellitus and found a small percentage of patients at high risk for heart failure. Male gender, prior stroke, chronic kidney disease, and newly detected atrial fibrillation were significantly associated with elevated NT-proBNP levels. The study suggests that NT-proBNP and ECG screening can aid in early detection of cardiovascular complications and improve long-term outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hok Shing Tang, Chi Ting Kwan, Jianlong He, Pan Pan Ng, Siu Han Jojo Hai, Fung Yu James Kwok, Ho Fung Sze, Man Hon So, Hong Yip Lo, Ho Tung Ambrose Fong, Eric Yuk Fai Wan, Chi-Ho Lee, Esther Yee Tak Yu, Yee Tak Alta Lai, Chun Yin Jonan Lee, Siu Ting Leung, Hiu Lam Chan, Hung Fat Tse, Dudley J. Pennell, Raad H. Mohiaddin, Roxy Senior, Andrew T. Yan, Kai-Hang Yiu, Ming-Yen Ng
Summary: This study evaluated the prognostic utility of feature tracking (FT) parameters derived from cardiac magnetic resonance imaging (MRI) and found that left ventricular global longitudinal strain (LV GLS) is a significant independent predictor of adverse outcomes in patients with dilated cardiomyopathy (DCM). LV GLS can be used as a clinical indicator for predicting the prognosis of DCM patients and strengthens the clinical implementation of FT in cardiac MRI.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Endocrinology & Metabolism
Jia-Yi Huang, Yi-Kei Tse, Hang-Long Li, Cong Chen, Chun-Ting Zhao, Ming-Ya Liu, Mei-Zhen Wu, Qing-Wen Ren, Si-Yeung Yu, Denise Hung, Xin-Li Li, Hung-Fat Tse, Gregory Y. H. Lip, Kai-Hang Yiu
Summary: This study evaluated the association between prediabetes and heart failure, as well as the association of heart failure with changes in glycemic status. The results showed that prediabetes was associated with an increased risk of heart failure, while reverting to normoglycemia was associated with a decreased risk of heart failure.
Article
Endocrinology & Metabolism
Chi-Ho Lee, David Tak-Wai Lui, Raymond Hang-Wun Li, Michele Mae-Ann Yuen, Carol Ho-Yi Fong, Ambrose Pak-Wah Leung, Justin Chiu-Man Chu, Loey Lung-Yi Mak, Tai-Hing Lam, Jean Woo, Yu-Cho Woo, Aimin Xu, Hung-Fat Tse, Kathryn Choon-Beng Tan, Bernard Man-Yung Cheung, Man-Fung Yuen, Karen Siu-Ling Lam
Summary: This study investigated whether incorporating additional metabolic risk factors improved liver fibrosis risk stratification in non-diabetic overweight/obese MAFLD individuals. The results showed that abnormal AST and HOMA-IR levels were independently associated with higher liver fibrosis risk, and a sequential screening algorithm using these factors was developed for risk identification.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Benjamin Y. F. So, Chun Ka Wong, Gordon Chun Kau Chan, Jack Kit Chung Ng, Grace Chung Yan Lui, Cheuk Chun Szeto, Ivan Fan Ngai Hung, Hung Fat Tse, Sydney C. W. Tang, Tak Mao Chan, Kai Ming Chow, Desmond Y. H. Yap
Summary: Hypernatraemia is common in COVID-19 patients, especially during the Omicron era. Patients with hypernatraemia have higher 30-day mortality and longer hospital stays. This study provides insights into the epidemiology and clinical outcomes of hypernatraemia in COVID-19 patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Gordon Chun Kau Chan, Chun Ka Wong, Benjamin Y. F. So, Jack Kit Chung Ng, Grace Chung Yan Lui, Cheuk Chun Szeto, Ivan Fan Ngai Hung, Hung Fat Tse, Sydney C. W. Tang, Tak Mao Chan, Kai Ming Chow, Desmond Y. H. Yap
Summary: This study investigates the epidemiology and outcomes of COVID-19 patients with hyponatremia. The results show that hyponatremic patients have higher 30-day mortality, prolonged hospitalization, and increased ICU admissions. Hyponatremia may serve as a prognostic indicator for unfavorable outcomes in COVID-19.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Chun-Ka Wong, Tsun-Ho Lam, Song-Yan Liao, Yee-Man Lau, Hung-Fat Tse, Benjamin Y. F. So
Summary: Despite the success of immune checkpoint inhibitors (ICIs) in cancer treatment, the occurrence of immune-related adverse events (IRAEs) is a major concern. ICI-induced myocarditis is a severe form of IRAE, and understanding its pathogenesis and treatment is still limited. Mouse models have been developed to study ICI-induced myocarditis, but additional interventions are required to mimic the pathology in humans. This review focuses on the immunopathogenesis of ICI-induced myocarditis and its potential implications for treatment.
Article
Psychology, Clinical
Rui Jiang, Ruijie Zeng, Qiu Xinqi, Huihuan Wu, Zewei Zhuo, Qi Yang, Jingwei Li, Felix W. Leung, Qizhou Lian, Weihong Sha, Hao Chen
Summary: This study examined the causal relationship between inflammatory bowel disease (IBD) and anorexia nervosa (AN) using two-sample Mendelian randomization (MR) analysis. The results showed that genetically predicted IBD was significantly associated with an increased risk of AN, while there was no evidence of a causal effect of AN on IBD. These findings may have clinical benefits for early detection of AN and management of IBD patients.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2023)
Article
Cell Biology
Eric Yuk Fai Wan, Anna Hoi Ying Mok, Vincent Ka Chun Yan, Cheyenne I. Ying Chan, Boyuan Wang, Francisco Tsz Tsun Lai, Celine Sze Ling Chui, Xue Li, Carlos King Ho Wong, Kai Hang Yiu, Hung Fat Tse, Chak Sing Lau, Ian Chi Kei Wong, Esther Wai Yin Chan
Summary: This study examines the risks of post-infection cardiovascular diseases (CVDs) among COVID-19 patients with different vaccination status. The findings indicate that vaccinated patients have a lower risk of CVD and all-cause mortality, with the lowest risk observed in those who completed three doses of vaccine. These results suggest a positive dose-response relationship between overall CVD risk reduction and the number of vaccine doses received.
CELL REPORTS MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Chi Ting Kwan, On Hang Samuel Ching, Pui Min Yap, Sau Yung Fung, Hok Shing Tang, Wan Wai Vivian Tse, Cheuk Nam Felix Kwan, Yin Hay Phoebe Chow, Nga Ching Yiu, Yung Pok Lee, Jessica Wing Ka Lau, Ambrose Ho Tung Fong, Qing-Wen Ren, Mei-Zhen Wu, Eric Yuk Fai Wan, Ka Chun Kevin Lee, Chun Yu Leung, Andrew Li, David Montero, Varut Vardhanabhuti, Jojo Siu Han Hai, Chung-Wah Siu, Hung-Fat Tse, Valentin Zingan, Xiaoxi Zhao, Haonan Wang, Dudley John Pennell, Raad Mohiaddin, Roxy Senior, Kai-Hang Yiu, Ming-Yen Ng
Summary: This study aimed to differentiate HFpEF patients from non-HFpEF patients and asymptomatic controls using intraventricular four-dimensional flow phase-contrast cardiovascular magnetic resonance. The results showed that CMR 4D flow derived LV direct flow and residual volume could effectively differentiate HFpEF patients from non-HFpEF patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Correction
Cardiac & Cardiovascular Systems
Candela Diaz-Canestro, Hung-Fat Tse, Kai-Hang Yiu, David Montero
EUROPEAN HEART JOURNAL
(2023)
Article
Health Care Sciences & Services
Xuxiao Ye, Caige Huang, Yue Wei, Silvia T. H. Li, Vincent K. C. Yan, Kai -Hang Yiu, Hung-Fat Tse, Tiantian Ma, Xiwen Qin, Celine S. L. Chui, Francisco T. T. Lai, Xue Li, Eric Y. F. Wan, Carlos K. H. Wong, Ian C. K. Wong, Esther W. Chan
Summary: This study aimed to investigate the safety of two COVID-19 vaccines, BNT162b2 and CoronaVac, in patients with heart failure (HF). The study found that there were no increased risks of hospitalization for HF, major adverse cardiovascular events (MACE), or all hospitalization after receiving these vaccines in patients with HF.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
X. Ye, E. S. Y. Chan, K. K. C. Man, C. K. Wong, H. F. Tse, E. W. Chan
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
N. M. C. Nga Man Carman Cheung, M. Z. Wu, Q. W. Ren, J. Y. Huang, Y. K. Tse, H. F. Tse, K. H. Yiu
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Letter
Cardiac & Cardiovascular Systems
Ho-Ting Ngan, Kwong-Yue Chan, Chun-Ka Wong, Ka-Chun Un, Shu-Yue Sze, Puigi Shea, Cheung-Chi Lam, Yui-Ming Lam, Chor-Cheung Tam, Chu-Pak Lau, Hung-Fat Tse
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)