4.6 Article

The Peptidoglycan Hydrolase of Staphylococcus aureus Bacteriophage φ11 Plays a Structural Role in the Viral Particle

期刊

APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 79, 期 19, 页码 6187-6190

出版社

AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.01388-13

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资金

  1. Ministry of Science and Innovation, Spain [AGL2009-13144-C02-01]
  2. CSIC, Spain [PIE200970I090]
  3. bacteriophage network FAGOMA
  4. Science, Technology and Innovation Programme, Principado de Asturias, Spain [IB08-052]
  5. Ministerio de Ciencia e Innovacion, MICINN [BIO2011-30503-C02-01, PIM2010EPA-00606]

向作者/读者索取更多资源

The role of virion-associated peptidoglycan hydrolases (VAPGHs) in the phage infection cycle is not clear. gp49, the VAPGH from Staphylococcus aureus phage phi 11, is not essential for phage growth but stabilizes the viral particles. phi 11 Delta 49 phages showed a reduced burst size and delayed host lysis. Complementation of gp49 with HydH5 from bacteriophage vB_SauS-phi-IPLA88 restored the wild-type phenotype.

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