Review
Engineering, Biomedical
Hang Yin, Ziyi Jin, Wenjia Duan, Bing Han, Limei Han, Cong Li
Summary: This review highlights the importance of cancer metabolic reprogramming and tumor-associated metabolites in tumor occurrence and progress. It focuses on the recent advances in stimuli-responsive SERS probes, the mechanisms of responsive SERS signals triggered by tumor metabolites, and the biomedical applications of these probes.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Analytical
Di Liu, Huimin Gao, Wenji Jiang, Su Yan, Hao Liu, Junjie Chen, Sisi Wen, Wei Zhang, Xu Wang, Bing Zhao, Wei Song
Summary: In this study, three-dimensional Ag aerogel-supported Hg single-atom catalysts were used as an efficient SERS substrate for monitoring enhanced oxidase-like reactions. The effect of Hg2+ concentrations on the SERS properties of 3D Hg/Ag aerogel networks was investigated, and an optimized addition of Hg2+ resulted in specific enhancement. The formation of Ag-supported Hg SACs was confirmed using HAADF-STEM imaging and XPS measurement, and the oxidase-like catalytic mechanism of Hg/Ag SACs was revealed using DFT. This research provides a mild synthetic strategy for fabricating Ag aerogel-supported Hg single atoms with promising prospects in various catalytic fields.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shi Xuan Leong, Ya-Chuan Kao, Xuemei Han, Zhong Wei Poh, Jaslyn Ru Ting Chen, Emily Xi Tan, Yong Xiang Leong, Yih Hong Lee, Wei Xuan Teo, George W. Yip, Yulin Lam, Xing Yi Ling
Summary: This study demonstrates the use of charge and geometry complementarity to achieve high spectral specificity in surface-enhanced Raman scattering (SERS) molecular recognition. By leveraging this approach, accurate differentiation and quantification of structurally similar biomolecules can be achieved, which holds significance in fields such as biodiagnostics, food, and environmental surveillance.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Materials Science, Multidisciplinary
Si-Zhe Sheng, Shi-Qiao Zheng, Xue-Fei Feng, Ling-Ran Zhou, Zhen-Chao Tao, Jian-Wei Liu
Summary: This study provides a new strategy for assembling ordered structures of gold nanoparticles using highly ordered nanowire templates to explore the ordering effect on SERS performance. The highly ordered gold nanoparticle arrays show improved detection limit and enhancement factor compared to disordered gold particles.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Hiroki Makanai, Tatsuya Nishihara, Kazuhito Tanabe
Summary: In this study, a purification-free method based on surface-enhanced Raman scattering (SERS) using functionalized gold nanoparticles was developed for the detection of specific nucleic acids. The robust Raman signal of an acetylene-tagged Hoechst molecule (AH) was identified through SERS, and the target nucleic acids were detected through strand displacement and dissociation processes.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Analytical
Guohua Qi, Jiafeng Wang, Kongshuo Ma, Ying Zhang, Jie Zhang, Weiqing Xu, Yongdong Jin
Summary: By developing a micron-nano composite probe, real-time monitoring of PS externalization during cell apoptosis was achieved, revealing differences in cell membrane damage between cancerous cells and normal cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Tingting Dai, Zhen Xiao, Dingying Shan, Angel Moreno, Hongquan Li, Manu Prakash, Niaz Banaei, Jianghong Rao
Summary: In this study, a fast and culture-independent method for detecting extended-spectrum beta-lactamases (ESBLs) using surface-enhanced Raman scattering (SERS) was proposed. Raman probes were used to release sulfur-based Raman active molecules in the presence of beta-lactamases, and the released thiol molecules were captured by gold nanoparticles to amplify the Raman signals. The designed probes enabled duplex detection of bacteria expressing broad-spectrum beta-lactamases or ESBLs with a detection limit of 10^3 cfu/mL in 1 hour incubation, reducing the screening time to 1.5 hours with a portable Raman microscope.
Article
Chemistry, Multidisciplinary
Renting Jiang, Jianqin Li, Linhu Li, Yaxuan Lu, Huiming Zhang, Ming Li
Summary: This study investigates the plasmonic and photothermal properties of spiky Au nanoparticles with different shaped central cores, and reveals that spiky Au nanospheres and spiky Au nanocubes are superior for SERS detection and hyperthermia therapy compared to spiky Au nanorods.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
W. Cheuquepan, S. Hernandez, M. Perez-Estebanez, L. Romay, A. Heras, A. Colina
Summary: Electrochemistry can be used to generate SERS substrates, utilizing the plasmonic properties of nanos-tructures and the chemical mechanism, with time-resolved Raman spectroelectrochemistry providing valuable information. Comparing Au and Ag metals for folic acid detection in drugs, it was found that Ag SERS substrates outperformed Au SERS substrates in complex samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jean-Francois Bryche, Marlo Vega, Agnes Tempez, Thibault Brule, Thomas Carlier, Julien Moreau, Marc Chaigneau, Paul G. Charette, Michael Canva
Summary: This work demonstrates the enhancement in plasmonic sensing efficacy by spatially-localized functionalization on nanostructured surfaces, where probe molecules are concentrated in areas of high field concentration. SERS measurements on nanostructured surfaces with homogeneous and spatially-localized functionalization with thiophenol show that the Raman signal mainly originates from high field concentration areas. TERS measurements with 10 nm spatial resolution confirm the predicted field distribution profiles.
Article
Multidisciplinary Sciences
Yun A. Hong, Ji Won Ha
Summary: This study investigated the refractive index sensitivities of single hollow gold nanospheres (HAuNS) and single solid gold nanospheres (AuNS) in different media. The HAuNS with thin Au shell and inner cavity showed improved refractive index sensitivity compared to the AuNS. Furthermore, the HAuNS exhibited better refractive index sensitivity at the homogeneous LSPR scattering inflection points (IFs).
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Shota Takahashi, Atsunori Sakurai, Tatsuto Mochizuki, Toshiki Sugimoto
Summary: In this study, we achieved significant enhancement of the nonlinear optical response in a tip-substrate plasmonic nanocavity. By focusing on the near-field second harmonics of a wavelength-tunable femtosecond laser, we demonstrated that the enhancement of nonlinear optical effects occurs over a broad wavelength range from visible to infrared. We also discovered that the sharpness of the tip apexes and the surface geometry of the tip shafts both affect the broadband nonlinear optical property.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Shi Xuan Leong, Charlynn Sher Lin Koh, Howard Yi Fan Sim, Yih Hong Lee, Xuemei Han, Gia Chuong Phan-Quang, Xing Yi Ling
Summary: The study successfully achieves direct, label-free SERS sensing of biologically important enantiomers by synergizing asymmetric nanoporous gold (NPG) nanoparticles with electrochemical-SERS. This strategy is versatile and can be readily extended to detect various enantiomers, and allows for multiplex quantification of enantiomeric ratios with excellent predictive performance. The research offers a paradigm shift in achieving label-free chiral SERS sensing of various enantiomers.
Article
Electrochemistry
Sheila Hernandez, Juan Perales-Rondon, Aranzazu Heras, Alvaro Colina
Summary: EC-SOERS is a new phenomenon that enhances the Raman signal during the oxidation of a metal surface. Studies show that carbonyl and carboxyl groups are necessary to observe this phenomenon, with a delocated charge being important factor. Evaluating the enhancement factors for different molecules with highly delocated charge and a carboxyl group sheds more light on the interaction of molecules with the electrochemically generated SOERS substrates.
ELECTROCHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Antonio Sasso, Angela Capaccio, Giulia Rusciano
Summary: This review focuses on the recent studies conducted by our group in the past decade, where novel nanofabrication techniques were successfully applied to SERS and TERS experiments for studying bio-systems and molecular species of environmental interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
