Article
Biochemistry & Molecular Biology
Adam Wronski, Izabela Dobrzynska, Szymon Sekowski, Wojciech Luczaj, Ewa Olchowik-Grabarek, Elzbieta Skrzydlewska
Summary: This study aimed to evaluate the effects of phytocannabinoids (CBD and CBG), used singly and in combination, on the composition and function of keratinocyte membranes exposed to UVA radiation. The results showed that the combined use of CBD and CBG partially prevented the increase in phosphatidylinositols, sialic acid, and sphingomyelinase activity induced by UVA radiation in keratinocytes. Simultaneous use of these phytocannabinoids also reduced the formation of lipid rafts and malondialdehyde, preserving the integrity and functionality of keratinocyte membranes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Xiaoran Wei, Nan Liu, Jian Song, Chao Ren, Xiaowen Tang, Wei Jiang
Summary: SiO2 nanoparticles can affect the fluidity of cell membranes, with a more significant impact at higher temperatures. Components such as phosphatidyl ethanolamine and phosphoinositide can mitigate the membrane gelation caused by the nanoparticles.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Chikako Shibata, Motoyuki Otsuka, Takahiro Seimiya, Kazunaga Ishigaki, Yu Miyakawa, Takahiro Kishikawa, Mitsuhiro Fujishiro
Summary: The size of EVs is influenced by different types of cancers, with EVs derived from pancreatic cancer cells being smaller than those from non-cancer cells. Low glucose conditions reduce EVs' size distribution and increase levels of unsaturated fatty acids in EVs. Increased uptake of smaller EVs by recipient cells may lead to enhanced functional outcomes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Food Science & Technology
Lohans Pedrera, Uris Ros, Maria Laura Fanani, Maria E. Lanio, Richard M. Epand, Ana J. Garcia-Saez, Carlos Alvarez
Summary: This study reveals that the size and stability of St I pores are heterogeneous and depend on the fluidity of the lipid bilayer. This has implications for designing different therapeutic strategies based on its lytic action.
Article
Microbiology
Siqi Tao, G. F. (Ciska) Veen, Naili Zhang, Tianhe Yu, Laiye Qu
Summary: Plant diversity plays a crucial role in plant community productivity, and this study demonstrates that bacterial and archaeal communities are important drivers of the relationship between plant diversity and productivity in subtropical forests. The research shows that tree and shrub richness affect tree productivity by regulating bacterial and archaeal community diversity and composition.
Review
Cell Biology
Amit S. Joshi
Summary: Peroxisomes are vital organelles in cells, generated and maintained through membrane contacts with other organelles, playing a crucial role in normal cellular function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Timea Hajdu, Krisztina Szabo, Agnes Jakab, Istvan Pocsi, Viktor Dombradi, Peter Nagy
Summary: The cell membrane of Ppz1-KO Candida albicans displays increased sensitivity to oxidative damage, characterized by increased lipid peroxidation, reduced lipid order, and inhibited lateral mobility of plasma membrane components. Changes in the biophysical characteristics of the plasma membrane are detectable in untreated Ppz1-KO cells, indicating latent membrane damage even in the absence of oxidative stress. Cells lacking Ppz1 show hypersensitivity to oxidative damage, suggesting potential synergistic effects between Ppz1 inhibitors and oxidizing agents in anti-fungal combination therapies.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Marvin Gohrbandt, Andre Lipski, James W. Grimshaw, Jessica A. Buttress, Zunera Baig, Brigitte Herkenhoff, Stefan Walter, Rainer Kurre, Gabriele Deckers-Hebestreit, Henrik Strahl
Summary: Living organisms adjust their membrane lipid composition in response to changes in their environment or diet. Understanding the key concepts of membrane biology linked to regulation of lipid composition is crucial, and in vitro studies have been relied upon heavily. However, research using bacterial organisms has shown that inadequate in vivo membrane fluidity can interfere with essential cellular processes, and very low membrane fluidity can trigger lipid phase separation and protein segregation in living cells.
Article
Chemistry, Multidisciplinary
Shaoying Dai, Xiaoyu Tang, Na Zhang, Haofei Li, Chengzhi He, Yuchun Han, Yilin Wang
Summary: This study investigates the effects of antibacterial amphiphiles on membrane bilayers and the invasion of bacteria into cell mimics.
Article
Food Science & Technology
Chunli Fan, Tingting Feng, Xingwei Wang, Shuqin Xia, Caleb John Swing
Summary: This study evaluated the encapsulation difference and stability mechanism of nanoliposomes loaded with different kinds and loads of liposoluble vitamins. It was found that VD and VE were not suitable for high-load encapsulation, but the stability of other LSV-NLPs was excellent during storage. LSV encapsulation inhibited malon-dialdehyde production, decreased liposome surface roughness, and improved nanoliposome rigidity. The accumulation of acyl chain was enhanced, and the interchain longi-tudinal and intra-chain transverse order degree was increased.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Environmental Sciences
Linqiong Wang, Yi Li, Zhe Zhao, Tristan Cordier, Isabelle A. Worms, Lihua Niu, Chenyang Fan, Vera Slaveykova
Summary: This study investigated the changes in TBBPA and Cu concentrations and microbial community responses in co-contaminated sediments during long-term incubation. Fungal communities showed a stronger response to pollutant addition after a long incubation compared with bacterial and archaeal communities. Bacterial, archaeal, and fungal microbial communities were distinctly distributed into two separated clusters according to incubation time, indicating temporal changes in response.
Article
Food Science & Technology
Chontida Tangsongcharoen, Jose L. Toca-Herrera, Boonhiang Promdonkoy, Sudarat Tharad
Summary: This study investigated the importance of the conserved T144 residue in the alpha D-beta 4 loop of Cyt2Aa2 protein for lipid binding on fluid lipid membranes. The results showed that replacing threonine with alanine hinders the binding of Cyt2Aa2 on liquid lipid membranes, providing a possibility to modify the protein to specific cells via lipid phase selection.
Article
Biochemistry & Molecular Biology
Balint Csoboz, Imre Gombos, Zoltan Kota, Barbara Dukic, Eva Klement, Vanda Varga-Zsiros, Zoltan Lipinszki, Tibor Pali, Laszlo Vigh, Zsolt Torok
Summary: In this study, the interaction between HSPB1 and phospholipids was characterized, revealing that HSPB1 associates with membrane-forming lipids and has a strong affinity towards highly fluid membranes. HSPB1 modulates the physical properties of interacting membranes by altering lipid mobility and greatly affects the phase behavior of the plasma membrane under membrane fluidizing stress conditions. These findings suggest a new function for HSPB1 as a membrane chaperone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jessica R. Willdigg, John D. Helmann
Summary: This review focuses on the stress responses triggered by antibiotics and other agents that disrupt the synthesis or integrity of the bacterial cell envelope, specifically looking at Bacillus subtilis. It highlights how altering the composition and properties of the membrane and its associated proteome can protect cells against various compounds and contribute to resistance, potentially playing a crucial role in the emergence of antibiotic resistance in clinical settings. The regulatory responses discussed in the review are broadly conserved, with the potential to vary in regulation details, but can still be significant in clinical contexts.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Reproductive Biology
Bryan Blawut, Barbara Wolfe, Chris Premanandan, Gustavo Schuenemann, Stuart A. Ludsin, Shan-Lu Liu, D. N. Rao Veeramachaneni, Marco A. Coutinho da Silva
Summary: The sperm plasma membrane is crucial for fertilization, but assisted reproduction techniques can harm it and reduce fertility. While there has been extensive research on fish sperm membrane, few studies have examined the effects of cryopreservation and other assisted reproduction techniques on membrane composition, characteristics, and organization. This study investigated the impact of testicular harvest, strip spawning, and cryopreservation on the sperm plasma membrane using Sauger sperm. The results revealed that these techniques can significantly affect the membrane, providing potential biomarkers for sperm quality and insight into sub-fertility caused by assisted reproduction techniques.