期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 76, 期 15, 页码 5300-5304出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.00851-10
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资金
- Canadian Institutes of Health Research
- Crohn's and Colitis Foundation of Canada
- Department of Foreign Affairs and International Trade Canada
- National Sciences and Engineering Research Council of Canada
- Swiss National Science Foundation
- Human Frontier Science Program
We show that dimethyl sulfoxide (DMSO) inhibits Salmonella hilA expression and that this inhibition is stronger under anaerobiosis. Because DMSO can be reduced to dimethyl sulfide (DMS) during anaerobic growth, we hypothesized that DMS was responsible for hilA inhibition. Indeed, DMS strongly inhibited the expression of hilA and multiple Salmonella pathogenicity island 1 (SPI-1)-associated genes as well as the invasion of cultured epithelial cells. Because DMSO and DMS are widespread in nature, we hypothesize that this phenomenon may contribute to environmental sensing by Salmonella.
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