Article
Engineering, Environmental
Akbar Rajabi, Davoud Farajzadeh, Reza Dehghanzadeh, Hassan Aslani, Saeid Mousavi, Mohammad Mosaferi, Mohammad Hadi Dehghani, Farzaneh Baghal Asghari
Summary: Municipal water resource recovery facilities are important sources of antibiotic-resistant bacteria, with Pseudomonas spp., Acinetobacter spp., and Escherichia coli being the predominant resistant bacteria. The biological treatment has little effect on bacteria abundance, while the disinfection unit may lead to an increase in bacteria count. All tested isolates show resistance to at least four antibiotics.
WATER ENVIRONMENT RESEARCH
(2022)
Review
Multidisciplinary Sciences
Abdulaziz Alqasim
Summary: Gram-negative bacteria (GNB) pose a significant health threat globally, with increasing antimicrobial resistance leading to the need for colistin treatment. Saudi Arabia's annual mass religious gatherings heighten the risk of infectious disease transmission. While colistin remains effective locally, high resistance has been observed among major GNB, and the role of mass gatherings in triggering colistin resistance is concerning.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Jinzhong Cai, Huang Yishun, Weiyun Zhang
Summary: A novel method for detecting coliform bacteria using a simple technology has been developed, enabling rapid and accurate detection of coliform bacteria in various food and water samples.
CHEMICAL COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Mutasim E. Ibrahim
Summary: This study investigated the prevalence and risk factors for multidrug-resistant Klebsiella pneumoniae infection among hospitalized patients in southern Saudi Arabia. The study found that 66.8% of patients were infected with multidrug-resistant K. pneumoniae strains. Factors such as gender, age, intensive care unit admission, invasive medical devices, and chronic illness were significantly associated with the infection.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Akbar Rajabi, Davoud Farajzadeh, Reza Dehghanzadeh, Hassan Aslani, Mohammad Mosaferi, Saeid Mousavi, Dariush Shanehbandi, Farzaneh Baghal Asghari
Summary: This study aimed to investigate the impact of ozonation on inactivation of antibiotic-resistant bacteria (ARB) and removal of associated antibiotic-resistant genes (ARGs) in effluent of a municipal wastewater treatment plant. The results showed that specific ozone doses followed the Chick-Watson model for bacterial inactivation rates. The highest reductions in A. baumannii, E. coli, and P. aeruginosa were achieved with a ozone dose of 0.48 gO(3)/gCOD at 12 minutes contact time. Complete inactivation of ARB and bacterial regrowth were not observed after 72 hours incubation. ARGs were found to be more persistent to ozone than ARB.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Chih-Yu Ma, Yoshinori Sugie, Zaizhi Yu, Yoshiki Okuno, Hiroaki Tanaka, Masaru Ihara
Summary: The emergence of antibiotic-resistant bacteria poses a serious challenge to human, animal, and environmental health worldwide. A study in Japan found that antibiotic-resistant E. coli was prevalent in Lake Biwa and inflow rivers, with similar resistance patterns to clinical samples. The numbers of antibiotic-resistant E. coli decreased during wastewater treatment processes, but the resistance rates increased, suggesting selection for antibiotic resistance during treatment.
Article
Infectious Diseases
Pongthep Tabut, Rapeepan Yongyod, Ratchadaporn Ungcharoen, Anusak Kerdsin
Summary: This study examined the antibiotic resistance of Escherichia coli (E. coli) in surface water, wastewater, and discharge water in the Namsuay watershed in Thailand. The results showed that E. coli was resistant to multiple classes of antibiotics and carried various antibiotic resistance genes. E. coli isolates from discharge water had higher prevalence of antibiotic resistance and harboured more resistance genes.
Article
Chemistry, Multidisciplinary
Monica Paesa, Fernando Almazan, Cristina Yus, Victor Sebastian, Manuel Arruebo, Luis M. Gandia, Santiago Reinoso, Ismael Pellejero, Gracia Mendoza
Summary: This study investigates the antimicrobial performance of polyoxometalate-stabilized gold nanoparticles against Escherichia coli and Staphylococcus aureus, finding that one particular composite exhibits excellent bactericidal efficiency without harming mammalian cells.
Review
Infectious Diseases
Chunming Xu, Lingqiang Kong, Yonghong Liao, Yuan Tian, Qi Wu, Haosi Liu, Xiumin Wang
Summary: This review explores the prevalence trends of antibiotic-resistant (AR) Escherichia coli from farm animals, waste treatment, and aquatic environments. It highlights the increasing prevalence of AR E. coli from food animals, products, and animal waste, but a decrease at waste treatment plants. Various methods like UV treatment, surface plasma oxidation, and biochar are effective in eliminating AR E. coli. Probiotics, plant extracts, and antimicrobial peptides (AMPs) are emerging as promising alternatives to antibiotics. The review emphasizes that AR E. coli from farm animal-associated sources poses a serious global threat to public health.
Article
Microbiology
Vidar Sorum, Emma L. Oynes, Anna S. Moller, Klaus Harms, Orjan Samuelsen, Nicole L. Podnecky, Pal J. Johnsen
Summary: This study investigates the stability of collateral networks in ciprofloxacin-resistant Escherichia coli strains. The results show that the collateral effects caused by resistance development are not stable, complicating the general applicability and clinical implementation of collateral effects in treatment strategies.
Article
Multidisciplinary Sciences
Nubwa Medugu, Isabella A. Tickler, Carissa Duru, Ruth Egah, Abu Ocheiku James, Vivian Odili, Fatima Hanga, Eyinade Kudirat Olateju, Binta Jibir, Bernard E. Ebruke, Grace Olanipekun, Fred C. Tenover, Stephen K. Obaro
Summary: This study characterized the phenotypic and genotypic profiles of multi-drug resistant Enterobacterales isolated from patients in Nigerian hospitals. The isolates showed high resistance rates to third-generation cephalosporins and carbapenems. The most common resistance genes were bla(TEM-1B), bla(CTX-M-15), and bla(NDM-1). High-risk clones and potential treatment options were also identified.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Nurulain Idris, Kok Hoong Leong, Eng Hwa Wong, Nusaibah Abdul Rahim
Summary: This study evaluated the antibacterial efficacy and cytotoxicity of polymyxin B in combination with chloramphenicol and its derivatives in treating multidrug-resistant Klebsiella pneumoniae. The combination of polymyxin B and florfenicol showed the best antibacterial effect and the least cytotoxicity on normal bone marrow cells.
JOURNAL OF ANTIBIOTICS
(2023)
Article
Chemistry, Multidisciplinary
Jinghang Xie, Ran Mu, Mingxi Fang, Yunfeng Cheng, Fiona Senchyna, Angel Moreno, Niaz Banaei, Jianghong Rao
Summary: This study presents a rapid screening assay for pathogenic bacteria resistant to lactam antibiotics, utilizing a fluorogenic probe that shows superior sensitivity in reporting the activity of beta-lactamases and allows for detection of resistant bacteria in urine samples within 2 hours.
Article
Infectious Diseases
Hui Xie, Yoshitoshi Ogura, Yoshihiro Suzuki
Summary: This study investigated the survival of E. coli in wastewater and the relationship between phylogenetic groups and antibiotic-resistant E. coli. The results showed that the prevalence of phylogroup B2 increased over time, along with an increase in antibiotic-resistant E. coli. The findings suggest that antibiotic-resistant B2 isolates have a higher survivability in treated wastewater.
Article
Infectious Diseases
Samuel Chosidow, Bruno Fantin, Irene Nicolas, Jean-Baptiste Mascary, Francoise Chau, Valerie Bordeau, Marie-Clemence Verdier, Pierre Rocheteau, Francois Guerin, Vincent Cattoir, Victoire de Lastours
Summary: Pep16, a newly developed antimicrobial pseudopeptide, shows synergy with colistin and can limit the emergence of resistance. In vitro and in vivo experiments demonstrated that Pep16 in combination with colistin is more effective in inhibiting bacterial growth and preventing the emergence of colistin-resistant mutants compared to colistin alone.
Correction
Multidisciplinary Sciences
Patrick Munk, Christian Brinch, Frederik Duus Moller, Thomas N. Petersen, Rene S. Hendriksen, Anne Mette Seyfarth, Jette S. Kjeldgaard, Christina Aaby Svendsen, Bram van Bunnik, Fanny Berglund, D. G. Joakim Larsson, Marion Koopmans, Mark Woolhouse, Frank M. Aarestrup
NATURE COMMUNICATIONS
(2023)
Article
Primary Health Care
Katarina Hedin, Alike W. van der Velden, Malene Plejdrup Hansen, Anna B. Moberg, Anca Balan, Pascale Bruno, Samuel Coenen, Eskild Johansen, Anna Kowalczyk, Peter Konstantin Kurotschka, Sanne R. van der Linde, Lile Malania, Jorn Rohde, Jan Verbakel, Heike Vornhagen, Akke Vellinga
Summary: This study conducted a long-term follow-up of non-hospitalized patients with COVID-19 and found that 52% of patients developed long-COVID. The most common symptom was fatigue, and these lingering symptoms had an impact on patients' daily activities. Obese patients took longer to recover compared to non-obese patients.
EUROPEAN JOURNAL OF GENERAL PRACTICE
(2023)
Review
Dermatology
G. Gethin, A. Vellinga, C. McIntosh, D. Sezgin, S. Probst, L. Murphy, P. Carr, J. Ivory, S. Cunningham, A. M. Oommen, Lokesh Joshi, C. Ffrench
Summary: Chronic wounds have a negative impact on individuals' quality of life, and odour is a well-known associated factor. This systematic review examines the effectiveness of topical interventions in managing the odour of chronic and malignant fungating wounds. The review suggests that while metronidazole may provide some improvement, there is a lack of standardized outcomes and robust clinical trials in this area. Further research is needed to evaluate the potential of metronidazole and other interventions in controlling wound odour.
JOURNAL OF TISSUE VIABILITY
(2023)
Review
Infectious Diseases
Nathaly Garzon-Orjuela, Sana Parveen, Doaa Amin, Heike Vornhagen, Catherine Blake, Akke Vellinga
Summary: Governments and healthcare organisations collect data on antibiotic prescribing for surveillance and use interactive dashboards to provide feedback and prompt changes in prescribing behaviour. This systematic review found that interactive dashboards may reduce antibiotic prescribing in primary care when combined with other educational or behavioural intervention strategies.
Article
Pediatrics
Malte Kohns Vasconcelos
Article
Infectious Diseases
M. Shah, A. Fleming, T. M. Barbosa, A. W. van der Velden, S. Parveen, A. Vellinga
Summary: This study aims to assess the quality of antibiotic prescribing, the impact of the COVID-19 pandemic, and identify opportunities for antimicrobial stewardship in Ireland. The results showed a significant reduction in antibiotic prescribing during the COVID-19 pandemic, with high prescription rates for bronchitis and tonsillitis. Targeted initiatives to reduce antibiotic prescribing for these conditions and the introduction of point-of-care testing were recommended to support appropriate antibiotic prescribing.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Health Care Sciences & Services
Claire Beecher, Sandra Galvin, Anne Cody, Paula R. Williamson, Karen Hughes, Oonagh Ward, Caitriona Creely, Declan Devane
Summary: This study assessed the impact of the Health Research Board (HRB) Ireland guidance on the uptake of core outcome sets (COSs). The study found low COS uptake in funding applications, but a change in the application question prompted an increase in reporting searches of the COS database. The study suggests more efforts are needed to facilitate COS development and adoption in clinical research.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Niamh Cahill, Brigid Hooban, Kelly Fitzhenry, Aoife Joyce, Louise O'Connor, Georgios Miliotis, Francesca McDonagh, Liam Burke, Alexandra Chueiri, Maeve Louise Farrell, James E. Bray, Niall Delappe, Wendy Brennan, Deirdre Prendergast, Montserrat Gutierrez, Catherine Burgess, Martin Cormican, Dearbhaile Morris
Summary: The emergence and dissemination of mobile colistin resistance (mcr) genes poses a significant threat to public health, as colistin is one of the last line treatment options for multi-drug resistant infections. This study identified several bacteria carrying mcr genes, mainly in water sources and wastewater, along with other multi-drug resistance genes. These findings highlight the need for further research to understand the role of the environment in the persistence and dissemination of antimicrobial resistance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Primary Health Care
Melanie E. Hoste, Marta Wanat, Nina Gobat, Marilena Anastasaki, Femke Boehmer, Slawomir Chlabicz, Annelies Colliers, Karen Farrell, Maria-Nefeli Karkana, John Kinsman, Christos Lionis, Ludmila Marcinowicz, Katrin Reinhardt, Ingmarie Skoglund, Paer-Daniel Sundvall, Akke Vellinga, Herman Goossens, Christopher C. Butler, Alike van der Velden, Sarah Tonkin-Crine, Sibyl Anthierens
Summary: During the first wave of the COVID-19 pandemic, patients consulting in primary care in eight European countries expressed the need for testing to identify the cause of their illness and manage uncertainty. Some patients testing positive for COVID-19 believed they were immune from future infection, affecting their behavior.
EUROPEAN JOURNAL OF GENERAL PRACTICE
(2023)
Article
Infectious Diseases
Akke Vellinga, Addiena Luke-Currier, Nathaly Garzon-Orjuela, Rune Aabenhus, Marilena Anastasaki, Anca Balan, Femke Boehmer, Valerija Bralic Lang, Slawomir Chlabicz, Samuel Coenen, Ana Garcia-Sangenis, Anna Kowalczyk, Lile Malania, Angela Tomacinschii, Sanne R. van der Linde, Emily Bongard, Christopher C. Butler, Herman Goossens, Alike W. van der Velden
Summary: This study examined the antibiotic prescribing for respiratory tract infections in general practices across European countries. The findings showed that some countries did not meet the appropriate prescribing standards for certain types of infections, and the antibiotic usage rates differed among countries, with Denmark and Spain having lower rates compared to others.
Article
Infectious Diseases
Benedikte Olsen Michalsen, Alice X. T. Xu, Sarah L. Alderson, Lars Bjerrum, Jamie Brehaut, Heiner C. Bucher, Janet Clarkson, Eilidh Duncan, Jeremy Grimshaw, Ronny Gunnarsson, Sigurd Hoye, Noah Ivers, Donna M. Lecky, Morten Lindbaek, Carl Llor, Pia Touboul Lundgren, Denise O'connor, Celine Pulcini, Craig Ramsay, Par-Daniel Sundvall, Theo Verheij, Kevin L. Schwartz
Summary: This study surveyed the activities and policies of the Joint Programming Initiative on Antimicrobial Resistance - Primary care Antibiotic Audit and Feedback Network (JPIAMR-PAAN) member countries in antibiotic stewardship efforts. The survey revealed gaps and variations in activities and funding sources. However, most countries have national antibiotic stewardship programs or policies aimed at supporting ongoing antimicrobial stewardship efforts and sustainability. The study concludes that JPIAMR-PAAN will continue to collaborate among its members to create best practice resources and toolkits for antibiotic audit and feedback interventions in primary care settings and identify research priorities.
JAC-ANTIMICROBIAL RESISTANCE
(2023)
Article
Primary Health Care
Alike W. van der Velden, Milensu Shanyinde, Emily Bongard, Femke Boehmer, Slawomir Chlabicz, Annelies Colliers, Ana Garcia-Sangenis, Lile Malania, Jozsef Pauer, Angela Tomacinschii, Ly-Mee Yu, Katherine Loens, Margareta Ieven, Theo J. Verheij, Herman Goossens, Akke Vellinga, Christopher C. Butler
Summary: During the early stages of the COVID-19 pandemic, GPs had difficulty accurately diagnosing SARS-CoV-2 infections based on clinical grounds alone. This led to under-advised care for some patients and potentially increased the spread of the virus.
EUROPEAN JOURNAL OF GENERAL PRACTICE
(2023)
Review
Infectious Diseases
Doaa Amin, Nathaly Garzon-Orjuela, Agustin Garcia Pereira, Sana Parveen, Heike Vornhagen, Akke Vellinga
Summary: This review examines the potential of using artificial intelligence (AI) to improve antibiotic prescribing for human patients. The findings suggest that using supervised machine learning models can reduce antibiotic prescriptions or predict inappropriate prescriptions, thereby improving antibiotic prescribing. However, the implementation process of these models in clinical practices has not been evaluated.
Article
Public, Environmental & Occupational Health
Hilary Humphreys, Martin Cormican, Wendy Brennan, Karen Burns, Diarmuid O'Donovan, Therese Dalchan, Shirley Keane, Anne Sheahan
Summary: The study found that there is still a chance to prevent the endemic spread of CPE in hospitals, but efforts to control damp environmental reservoirs and improve antibiotic stewardship are needed. Additionally, there is currently no requirement to extend screening to detect CPE outside of acute hospitals.
EPIDEMIOLOGY AND INFECTION
(2022)
Review
Infectious Diseases
Sinead Duane, Claire Beecher, Akke Vellinga, Andrew W. Murphy, Martin Cormican, Andrew Smyth, Patricia Healy, Michael Moore, Paul Little, Declan Devane
Summary: This article examines the core outcomes reported in clinical trials and systematic reviews of interventions for treating uncomplicated urinary tract infections (UTIs). The study finds that comparing the outcomes of these trials is challenging due to the heterogeneity in reported outcomes. The authors suggest the development of a minimum set of consistent outcomes to improve reporting consistency.
JAC-ANTIMICROBIAL RESISTANCE
(2022)
