期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 76, 期 10, 页码 3391-3397出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.02862-09
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资金
- Microbial Opportunistic Pathogens [2052-03-0013]
- Danish Research Council for Technology and Production Sciences [274-08-042]
- Technical University of Denmark
We determined mammalian cell invasion and virulence gene (inlA, inlB, and actA) sequences of Listeria monocytogenes strains belonging to a molecular subtype (RAPD 9) that often persists in Danish fish-processing plants. These strains invaded human placental trophoblasts less efficiently than other L. monocytogenes strains, including clinical strains, and they carry a premature stop codon in inlA. Eight of 15 strains, including the RAPD 9 and maternofetal strains, had a 105-nucleotide deletion in actA that did not affect cell-to-cell spread in mouse fibroblasts. The RAPD 9 strains may still be regarded as of low virulence with respect to human listeriosis.
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