4.6 Article

Identification of a Polyketide Synthase Coding Sequence Specific for Anatoxin-a-Producing Oscillatoria Cyanobacteria

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APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 75, 期 14, 页码 4909-4912

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AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.02478-08

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  1. Institut Pasteur
  2. Ecole Nationale Superieure de Chimie de Paris
  3. Centre National de la Recherche Scientifique [URA 2172, UMR 7573]
  4. Aventis Pharma
  5. Bayer Pharma. C. Peyraud-Thomas
  6. Agence Francaise de Securite Sanitaire de l'Environnement

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We report the identification of a sequence from the genome of Oscillatoria sp. strain PCC 6506 coding for a polyketide synthase. Using 50 axenic cyanobacteria, we found this sequence only in the genomes of Oscillatoria strains producing anatoxin-a or homoanatoxin-a, indicating its likely involvement in the biosynthesis of these toxins.

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