Article
Chemistry, Multidisciplinary
Leandro W. Figueira, Beatriz H. D. Panariello, Cristiane Y. Koga-Ito, Simone Duarte
Summary: Low exposure times of low-temperature plasma affect the viability of single- and multi-species cariogenic biofilms, showing promising potential for the development of new protocols for the control of dental caries.
APPLIED SCIENCES-BASEL
(2021)
Article
Microbiology
Yang Zhou, Zhuoying Liu, Jie Wen, Yan Zhou, Huancai Lin
Summary: This study found that berberine chloride hydrate (BH) effectively suppresses the biofilm formation and cariogenic virulence of Streptococcus mutans (S. mutans). The inhibitory effect of BH is reduced under acidic condition and elevated under alkaline condition. BH can maintain good structural stability and low toxicity to erythrocytes at different pH values. Furthermore, BH downregulates the expression of certain genes related to adhesion and biofilm formation in S. mutans.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Yang Zhou, Zhuoying Liu, Jie Wen, Yan Zhou, Huancai Lin
Summary: This study investigated the antibiofilm activities of berberine chloride hydrate (BH) against Streptococcus mutans biofilm. The results showed that BH effectively suppressed S. mutans biofilm formation and cariogenic virulence. The inhibitory effect was influenced by pH values, with a reduced effect under acidic condition and an elevated effect under alkaline condition. BH maintained good structural stability and low toxicity to erythrocytes. The downregulation of critical genes involved in adhesion, bacterial colonization, and acid production explained the inhibitory effect of BH on S. mutans biofilm formation.
MICROBIOLOGY SPECTRUM
(2023)
Article
Plant Sciences
Sineenart Sanpinit, Kotchakorn Moosigapong, Siriporn Jarukitsakul, Kawinsak Jatutasri, Acharaporn Issuriya, Nantiya Joycharat, Katesarin Maneenoon, Patcharawalai Jaisamut, Sasitorn Chusri, Supayang Piyawan Voravuthikunchai, Korakot Wichitsa-nguan Jetwanna, Surasak Limsuwan
Summary: This study revealed that certain extracts from 35 herbal formulations in Thai traditional medicine exhibit anti-acidogenic effects against Streptococcus mutans and anti-quorum sensing activities. Specifically, THF-DC 02, THF-DC 04, THF-DC 20, and THF-DC 29 showed promising results in inhibiting acidogenesis or quorum sensing.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Microbiology
Yangyang Shi, Jingou Liang, Xuedong Zhou, Biao Ren, Haohao Wang, Qi Han, Hao Li, Lei Cheng
Summary: The study found that DMAEM@RA had a pH-responsive antimicrobial effect on Streptococcus mutans and Candida albicans dual-species biofilms, preventing secondary caries and attenuating cariogenic virulence.
Article
Food Science & Technology
Esra Boluk, Didem Sozeri Atik, Sevgi Kolayli, Ahmet Sukru Demirci, Ibrahim Palabiyik
Summary: Chewing gums with propolis can enhance sensory properties and bioactivity. Proper amount of propolis can improve the overall acceptance and antioxidant power. Propolis is suitable for drug delivery system in chewing gum formulations.
Review
Immunology
Xiuqing Wang, Jingling Li, Shujun Zhang, Wen Zhou, Linglin Zhang, Xiaojing Huang
Summary: Dental biofilms are highly organized bacterial communities protected by an extracellular matrix. These biofilms can become acidic under hostile conditions, leading to an imbalance in the microbial population and ultimately causing dental caries. Recent research has focused on designing pH-activated strategies to control dental caries, such as pH-responsive antimicrobial agents and drug delivery systems. These strategies selectively target acidic biofilms without disrupting the neutral microenvironment and biodiversity in the mouth.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Da-Young Kang, Andy Kim, Jeong Nam Kim
Summary: This study reveals that the transcription of the CRISPR-Cas system in the oral pathogen S. mutans is directly regulated by the binding of CcpA and CodY, two global regulators. This regulation plays a crucial role in carbohydrate metabolism and (p)ppGpp synthesis, contributing to the maintenance of cellular metabolism balance and rapid response to environmental cues.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Wentao Jiang, Zhuo Xie, Shuheng Huang, Qiting Huang, Lingling Chen, Xianling Gao, Zhengmei Lin
Summary: Novel ecological antimicrobial approaches to dental caries aim to inhibit cariogenic pathogens while promoting the growth of health-associated commensal communities or suppressing cariogenic virulence without affecting the diversity of oral microbiota, highlighting the importance of establishing a healthy microbiome in caries prevention.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Microbiology
Yongliang Li, Guanwen Li, Xuliang Deng
Summary: We developed a tightly controlled xylose-inducible gene expression system, TC-Xyl, for Streptococcus mutans. The system showed low non-inducible basal expression and high expression post-induction. By studying a mutation in which FtsZ was under the control of TC-Xyl, we found that FtsZ depletion led to abnormal cell shape and mini cell formation in Streptococcus mutans, suggesting its role in maintaining cell shape stability.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Wentao Jiang, Junyuan Luo, Yufei Wang, Xiangshu Chen, Xuelian Jiang, Zening Feng, Linglin Zhang
Summary: The research found that GH12 exhibited stronger antibacterial and antibiofilm activities in acidic environments, making it a potential smart anticaries agent targeting cariogenic acidic microenvironments.
Article
Biotechnology & Applied Microbiology
Chengkun Zheng, Man Wei, Jun Qiu, Mengdie Jia, Xiaohui Zhou, Xinan Jiao
Summary: The metalloregulator TroR in Streptococcus suis is essential for resistance to metal toxicity and virulence, with its deletion resulting in significant upregulation of the troABCD operon and decreased virulence in an intranasal mouse model. TroR contributes to maintaining metal homeostasis and playing a negative regulatory role in the TroABCD system.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Seung-Yong Song, Franklin Garcia-Godoy, Yong Hoon Kwon, Jeong-Kil Park
Summary: This study aimed to test the feasibility of using nitrogen-doped TiO2 nanoparticles for killing Streptococcus mutans (S. mutans) in a short-term treatment. The results showed that the antibacterial effect of N-TiO2 was slightly better than that of TiO2, regardless of the test condition. Additionally, the killing effect of 405nm laser treatment was slightly better than that of 660nm laser treatment.
AMERICAN JOURNAL OF DENTISTRY
(2022)
Article
Medicine, Research & Experimental
Xianhai Zeng, Xiaojun Xiao, Suqin Hu, Weiyi He, Gaohui Wu, Xiaorui Geng, Jialiang Fan, Longpeng Ma, Jiangqi Liu, Zhiqiang Liu, Pingchang Yang
Summary: This study reveals the crucial role of XBP1 in Th2 polarization, particularly in airway allergy, and identifies it as a potential therapeutic target. Inhibiting XBP1 can alleviate Th2 polarization-related immune inflammation in the airways.
Article
Immunology
Shuhei Naka, Daiki Matsuoka, Kana Goto, Taro Misaki, Yasuyuki Nagasawa, Seigo Ito, Ryota Nomura, Kazuhiko Nakano, Michiyo Matsumoto-Nakano
Summary: This study investigated the function and biological properties of the protein Cnm in Streptococcus mutans and found that Cnm is associated with cell surface structure, biofilm formation, and membrane permeability.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Lin Zeng, Robert A. Burne
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
Zachary D. Moye, Minjun Son, Ariana E. Rosa-Alberty, Lin Zeng, Sang-Joon Ahn, Stephen J. Hagen, Robert A. Burne
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2016)
Article
Microbiology
Robert C. Shields, Lin Zeng, David J. Culp, Robert A. Burne
Article
Biotechnology & Applied Microbiology
Lin Zeng, Lulu Chen, Robert A. Burne
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2018)
Article
Microbiology
Lin Zeng, Robert A. Burne
JOURNAL OF BACTERIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Lulu Chen, Brinta Chakraborty, Jing Zou, Robert A. Burne, Lin Zeng
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Microbiology
Lin Zeng, Alejandro R. Walker, Kyulim Lee, Zachary A. Taylor, Robert A. Burne
Summary: Genetic truncations in a gene encoding a putative glucose-phosphotransferase system protein were identified in subpopulations of Streptococcus sanguinis SK36 laboratory stocks. Deletion mutants of the gene showed improved bacterial viability and increased ability to inhibit the growth of the caries pathogen Streptococcus mutans. The mutants underwent reprogramming of central carbon metabolism, increasing production of hydrogen peroxide and excretion of pyruvate.
JOURNAL OF BACTERIOLOGY
(2021)
Article
Microbiology
Brinta Chakraborty, Lin Zeng, Robert A. Burne
Summary: Carbohydrate metabolism and acid production are vital for the development of dental caries. The formation and breakdown of fructans increase the severity of caries caused by S. mutans. S. mutans has the ability to degrade fructans, which contributes to the severity of dental caries, especially when fructans are the primary source of carbohydrates.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Lin Zeng, Alejandro R. Walker, Robert A. Burne, Zachary A. Taylor
Summary: Mutants with defects in the primary glucose phosphotransferase permease of Streptococcus sanguinis showed enhanced fitness at low pH and altered metabolism. These findings have important implications for understanding streptococcal fitness and metabolic interactions, and can contribute to further research on dental caries development.
JOURNAL OF BACTERIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Lulu Chen, Alejandro R. Walker, Robert A. Burne, Lin Zeng
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Microbiology
Jacqueline Abranches, Lin Zeng, Jessica K. Kajfasz, Sara Palmer, Brinta Chakraborty, Zezhang Wen, Vincent P. Richards, L. Jeannine Brady, Jose A. Lemos
MICROBIOLOGY SPECTRUM
(2018)
Article
Biotechnology & Applied Microbiology
Lin Zeng, Brinta Chakraborty, Tanaz Farivar, Robert A. Burne
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2017)
Article
Microbiology
J. A. Lemos, S. R. Palmer, L. Zeng, Z. T. Wen, J. K. Kajfasz, I. A. Freires, J. Abranches, L. J. Brady
MICROBIOLOGY SPECTRUM
(2019)