Article
Microbiology
Yu Su, Yuta Michimori, Haruyuki Atomi
Summary: The hyperthermophilic archaeon Thermococcus kodakarensis uses amino acids as a carbon and energy source. Two Class I aminotransferases, TK0548 and TK2268, are responsible for the conversion of specific amino acids. Genetic examination reveals their importance in amino acid metabolism.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Christian Fink, Gines Martinez-Cano, Jeremiah Shuster, Aurora Panzera, Kim E. Rennhack, Nils Rohbohm, Largus T. Angenent, Bastian Molitor
Summary: This study investigates the genetic basis and functional role of Mth60 fimbriae in Methanothermobacter thermautotrophicus Delta H. The researchers performed constitutive expression and deletion experiments of Mth60 fimbria-encoding genes in the organism. They found that overexpression increased the number of fimbriae, while deletion led to their loss in planktonic cells. The presence or absence of Mth60 fimbriae correlated with the formation of biotic cell-cell connections in the strains.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Hematology
Quint P. Hottentot, Emile de Meijer, Henk P. J. Buermans, Stefan J. White, Cornelis L. Harteveld
Summary: The study successfully utilized gDNA TLA technology to identify deletion breakpoints within the alpha-globin gene cluster. A rare 16,771 bp deletion was characterized, previously described incorrectly as --(gb) due to lack of registration in available databases. The deletion was confirmed in 10 carriers with similar MLPA results.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Article
Medicine, General & Internal
Shuhang Wang, Hui-Yao Huang, Dawei Wu, Hong Fang, Jianming Ying, Ying Bai, Yue Yu, Yuan Fang, Ning Jiang, Chao Sun, Anqi Yu, Qi Fan, Shujun Xing, Yufen Ni, Wei Zhang, Chenhua Wu, Xinqian Ji, Hui Wang, Yaqian Guo, Qiyu Tang, Yuan Wang, Yu Tang, Ning Li
Summary: This study aims to evaluate the safety and efficacy of targeted drugs and immune checkpoint inhibitors for the treatment of rare solid tumors, aiming to improve treatment options and outcomes for patients with rare solid tumors.
Review
Oncology
Daniela Furrer, Dzevka Dragic, Sue-Ling Chang, Frederic Fournier, Arnaud Droit, Simon Jacob, Caroline Diorio
Summary: The study aimed to assess the association of genome-wide genetic and epigenetic alterations with the response to anti-HER2 agents in HER2-positive breast cancer patients. The findings suggest that genes of the PI3K pathway may play an important role in developing resistance to anti-HER2 agents in breast cancer patients.
CANCER DRUG RESISTANCE
(2022)
Article
Biochemical Research Methods
Julie E. Walker, Thomas J. Santangelo
Review
Microbiology
Alexandra M. Gehring, Julie E. Walker, Thomas J. Santangelo
JOURNAL OF BACTERIOLOGY
(2016)
Article
Microbiology
Peng Wang, Zhuoteng Yu, Thomas J. Santangelo, John Olesik, Yufeng Wang, Ekaterina Heldwein, Xin Li
JOURNAL OF BACTERIOLOGY
(2017)
Article
Microbiology
Brett W. Burkhart, Lubomira Cubonova, Margaret R. Heider, Zvi Kelman, John N. Reeve, Thomas J. Santangelo
JOURNAL OF BACTERIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Margaret R. Heider, Brett W. Burkhart, Thomas J. Santangelo, Andrew F. Gardner
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Multidisciplinary Sciences
Julie E. Walker, Olivia Luyties, Thomas J. Santangelo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Francesca Mattiroli, Sudipta Bhattacharyya, Pamela N. Dyer, Alison E. White, Kathleen Sandman, Brett W. Burkhart, Kyle R. Byrne, Thomas Lee, Natalie G. Ahn, Thomas J. Santangelo, John N. Reeve, Karolin Luger
Article
Microbiology
Alexandra M. Gehring, David P. Astling, Rie Matsumi, Brett W. Burkhart, Zvi Kelman, John N. Reeve, Kenneth L. Jones, Thomas J. Santangelo
FRONTIERS IN MICROBIOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Michael Clayton Speed, Brett W. Burkhart, Jonathan W. Picking, Thomas J. Santangelo
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2018)
Article
Microbiology
Travis J. Sanders, Breanna R. Wenck, Jocelyn N. Selan, Mathew P. Barker, Stavros A. Trimmer, Julie E. Walker, Thomas J. Santangelo
NATURE MICROBIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Craig J. Marshall, Thomas J. Santangelo
Article
Multidisciplinary Sciences
Craig J. Marshall, M. Zuhaib Qayyum, Julie E. Walker, Katsuhiko S. Murakami, Thomas J. Santangelo
Summary: Transcription termination is an important process in regulating gene expression, and the protein Eta has been identified as one of the factors involved in disrupting transcription elongation complexes. By studying the biochemical activities and crystal structure of Eta, researchers have gained insight into its role in transcription termination. The susceptibility of transcription elongation complexes to disruption by termination factors highlights the common features of transcription termination mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Elizabeth A. Watts, Sandra C. Garrett, Ryan J. Catchpole, Landon M. Clark, Travis J. Sanders, Craig J. Marshall, Breanna R. Wenck, Robert L. Vickerman, Thomas J. Santangelo, Ryan Fuchs, Brett Robb, Sara Olson, Brenton R. Graveley, Michael P. Terns
Summary: The histones in Pyrococcus furiosus play a crucial role in directing the integration of CRISPR spacers, ensuring accurate integration at the 5' end of the CRISPR array. This co-evolution of CRISPR arrays with chromosomal DNA binding proteins highlights the widespread role of DNA binding and bending in facilitating spacer integration.
NATURE MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Breanna R. Wenck, Thomas J. Santangelo
TRANSCRIPTION-AUSTIN
(2020)
Article
Biochemistry & Molecular Biology
Alexandra M. Gehring, Thomas J. Santangelo
TRANSCRIPTION-AUSTIN
(2017)