Article
Microbiology
Jiaqi Wang, Jiahuan Chen, Linquan Li, Huanyu Zhang, Daxin Pang, Hongsheng Ouyang, Xuemin Jim, Xiaochun Tang
Summary: Cardiac fibrosis is a fundamental process in cardiac remodeling and is associated with almost all types of cardiovascular diseases. This study explores the relationship between cardiac fibrosis and gut microbiota, finding that dysbiosis of the gut microbiota alone cannot cause cardiac fibrosis. However, healthy fecal microbiota transplantation can alleviate cardiac fibrosis. By targeting the gut microbiota and metabolites, such as probiotics, it is possible to develop new strategies for treating cardiovascular diseases.
MICROBIOLOGY SPECTRUM
(2022)
Article
Food Science & Technology
Zeng Zhang, Yuanyuan Wang, Yanjun Zhang, Kaining Chen, Haibo Chang, Chenchen Ma, Shuaiming Jiang, Dongxue Huo, Wenjun Liu, Rajesh Jha, Jiachao Zhang
Summary: The study revealed the synergistic effects of jackfruit seed sourced resistant starch (JSRS) and Bifidobacterium pseudolongum in improving hyperlipidemia in mice. This finding will contribute to the development of synbiotics for the treatment of hyperlipidemia in the future.
Article
Food Science & Technology
Weiling Guo, Bingyong Mao, Shumao Cui, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Hao Zhang
Summary: Intervention with B. pseudolongum strains Bp7 and Bp8 can alleviate colitis symptoms by inhibiting inflammation, enhancing antioxidant enzyme activity, maintaining intestinal barrier integrity, and modulating gut microbiota composition.
Article
Biotechnology & Applied Microbiology
Chiara Argentini, Leonardo Mancabelli, Giulia Alessandri, Chiara Tarracchini, Margherita Barbetti, Luca Carnevali, Giulia Longhi, Alice Viappiani, Rosaria Anzalone, Christian Milani, Andrea Sgoifo, Douwe van Sinderen, Marco Ventura, Francesca Turroni
Summary: The first microbial colonizers of the infant gut are members of the genus Bifidobacterium, which exhibit different activities beneficial to their host. However, Amoxicillin-clavulanic acid (AMC), the most commonly prescribed antibiotic during infancy, can reduce the diversity of gut microbiota. This study investigated the potential positive effects of AMC-resistant bifidobacterial strains in maintaining the diversity of gut microbiota during AMC treatment.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Jing Cheng, Arja Laitila, Arthur C. Ouwehand
Summary: This review investigates the roles of Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019 (TM)) in gut health and its mechanisms of action. Research supports the hypothesis that B. lactis HN019 (TM) has a beneficial role in maintaining intestinal barrier function and normal physiological function in immunosenescent elderly, as well as reducing intestinal transit time and increasing bowel movement frequency in functional constipation.
FRONTIERS IN NUTRITION
(2021)
Article
Agriculture, Multidisciplinary
Weiling Guo, Shumao Cui, Xin Tang, Yongqiu Yan, Feifei Xiong, Qiuxiang Zhang, Jianxin Zhao, Bingyong Mao, Hao Zhang
Summary: This study found that Bifidobacterium pseudolongum CCFM1253 can protect against lipopolysaccharide-induced acute liver injury by regulating inflammation, antioxidative enzymes, intestinal microbiota composition, and liver metabolism. Therefore, it has the potential to serve as a probiotic to improve host health.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Microbiology
Xin Qian, Peijun Tian, Guopeng Lin, Xinglong Xu, Gang Wang, Hao Zhang, Wei Chen
Summary: This study aimed to investigate the gut colonization capacity of Bifidobacterium breve CCFM1025 and developed a quantitative PCR assay based on a specific gene sequence. The results showed that CCFM1025 could be quantified in fecal samples and remained detectable in volunteer feces 14 days after cessation of administration, indicating its favorable colonization characteristics. Therefore, CCFM1025 has the ability to colonize the healthy human gut.
FUTURE MICROBIOLOGY
(2023)
Article
Microbiology
Jingpeng Yang, Lingtong Meng, Hong Yang
Summary: The study found that high doses of Bifidobacterium breve YH68 used alone or in combination with vancomycin and metronidazole have significant therapeutic effects on pCDI mice, reducing C. difficile numbers and toxin levels, decreasing inflammation, and improving tissue pathology. The combination also alleviates the damaging effect of antibiotics on the gut microbiota.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biotechnology & Applied Microbiology
Noa Mandelbaum, Lihan Zhang, Shaqed Carasso, Tamar Ziv, Sapir Lifshiz-Simon, Irina Davidovich, Ishai Luz, Elliot Berinstein, Tal Gefen, Tomer Cooks, Yeshayahu Talmon, Emily P. Balskus, Naama Geva-Zatorsky
Summary: This study examined the extracellular vesicles (EVs) secreted by a newly sequenced Gram-positive human gut symbiont strain, Bifidobacterium longum AO44. The EVs were found to have anti-inflammatory effects, inducing the secretion of IL-10 from splenocytes and dendritic cells (DC)-CD4+ T cells co-cultures. The protein content of the EVs was enriched in ABC transporters, quorum sensing proteins, and extracellular solute-binding proteins, which are known to play a significant role in the anti-inflammatory effects of other strains of B. longum. This study highlights the importance of bacterial vesicles in modulating the host immune system and suggests their potential as future therapeutics.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Microbiology
You-Tae Kim, Chul-Hong Kim, Joon-Gi Kwon, Jae Hyoung Cho, Young-Sup Shin, Hyeun Bum Kim, Ju-Hoon Lee
Summary: The complete genome sequence analysis of Bifidobacterium longum subsp. longum BCBL-583 isolated from a Korean female fecal sample showed its safety for human consumption as it lacked virulence factors and antibiotic resistance genes. It also exhibited potential benefits for food processing, cholesterol reduction, and anti-inflammation activities. Animal studies demonstrated that the administration of BCBL-583 to high-fat diet mice reduced cholesterol levels, decreased pro-inflammatory cytokines, and increased anti-inflammatory cytokines. Microbiome analysis revealed changes in gut microbiota composition, suggesting its potential for promoting gut health.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Silvia Saturio, Alicja M. Nogacka, Marta Suarez, Nuria Fernandez, Laura Mantecon, Leonardo Mancabelli, Christian Milani, Marco Ventura, Clara G. De Los Reyes-Gavilan, Gonzalo Solis, Silvia Arboleya, Miguel Gueimonde
Summary: The establishment of the gut microbiota is influenced by factors such as gestational age, delivery mode, and infant feeding habits, leading to qualitative and quantitative changes in the bifidobacterial population. Understanding the impact of perinatal factors on the gut microbiota, especially at low taxonomic levels, is crucial for the development of rational strategies for promoting a healthy early microbiota development. The study provides insights for selecting the most suitable Bifidobacterium species for different groups of neonates and developing bifidobacteria-based products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jinchi Jiang, Caie Wu, Chengcheng Zhang, Qingsong Zhang, Leilei Yu, Jianxin Zhao, Hao Zhang, Arjan Narbad, Wei Chen, Qixiao Zhai
Summary: This study found that different strains of B. longum have strain-specific effects in alleviating hypercholesterolemia, mainly due to differences in bile salt deconjugation ability, cholesterol assimilation ability, expressions of key genes involved in cholesterol metabolism, and alterations of gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Ayako Watanabe, Yukine Teragaki, Yasuyuki Kitaura, Takumi Tochio
Summary: 1-kestose is the smallest component of fructooligosaccharides and has significant bifidogenic effects. However, there is a lack of in vivo studies on the synergistic effects of 1-kestose and Bifidobacterium longum in the gut. We demonstrate the synergistic impact of this combination in mice by using an appropriate monitoring regimen.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Microbiology
Federico Fontanta, Giulia Alessandri, Chiara Tarracchini, Massimiliano Giovanni Bianchi, Sonia Mirjam Rizzo, Leonardo Mancabelli, Gabriele Andrea Lugli, Chiara Argentini, Laura Maria Vergna, Rosaria Anzalone, Giulia Longhi, Alice Viappiani, Giuseppe Taurino, Martina Chiu, Francesca Turroni, Ovidio Bussolati, Douwe van Sinderen, Christian Milani, Marco Ventura
Summary: The genomic era has generated a vast amount of genetic data in bacterial taxonomy, but there is currently no established approach to reliably identify reference strains. In this study, a comprehensive multi-omics approach was developed, using the Bifidobacterium genus as a test case, to identify the optimal reference strains.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Jong-Wook Yoo, Yoon-Jung Shin, Xiaoyang Ma, Young-Hoo Son, Hyo-Min Jang, Chang Kyun Lee, Dong-Hyun Kim
Summary: Gut microbiota dysbiosis is closely related to psychiatric disorders and inflammatory bowel disease. The transplantation of Enterobacteriaceae-rich gut microbiota can cause depression and colitis in mice. However, treatment with anti-inflammatory probiotics can alleviate these symptoms.
Article
Mycology
Cecilia V. Tapia, German Hermosilla, Paula Fortes, Claudio Alburquenque, Sergio Bucarey, Hugo Salinas, Paula I. Rodas, Maria Cristina Diaz, Fabien Magne
Article
Microbiology
Maria-Jose Valenzuela, Mario Caruffo, Yoani Herrera, Daniel A. Medina, Maximo Coronado, Carmen G. Feijoo, Salome Munoz, Daniel Garrido, Miriam Troncoso, Guillermo Figueroa, Magaly Toro, Angelica Reyes-Jara, Fabien Magne, Paola Nayarrete
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Infectious Diseases
Claudio Alburquenque, Jose Amaro, Marisol Fuentes, Mary A. Falconer, Claudia Moreno, Cristian Covarrubias, Cristian Pinto, Paula I. Rodas, Sergio A. Bucarey, German Hermosilla, Fabien Magne, Cecilia V. Tapia
Article
Dermatology
Cecilia V. Tapia, Christian Batarce, Jose Amaro, German Hermosilla, Paula I. Rodas, Fabien Magne
Article
Microbiology
Francisco J. Perez, Pablo A. Iturra, Carolina A. Ponce, Fabien Magne, Victor Garcia-Angulo, Sergio L. Vargas
FRONTIERS IN MICROBIOLOGY
(2019)
Review
Nutrition & Dietetics
Fabien Magne, Martin Gotteland, Lea Gauthier, Alejandra Zazueta, Susana Pesoa, Paola Navarrete, Ramadass Balamurugan
Article
Multidisciplinary Sciences
Vicente Perez-Brocal, Fabien Magne, Susana Ruiz-Ruiz, Carolina A. Ponce, Rebeca Bustamante, Viviana San Martin, Mireya Gutierrez, Gianna Gatti, Sergio L. Vargas, Andres Moya
SCIENTIFIC REPORTS
(2020)
Review
Nutrition & Dietetics
Martin Gotteland, Karla Riveros, Naschla Gasaly, Constanza Carcamo, Fabien Magne, Gianella Liabeuf, Alejandra Beattie, Sebastian Rosenfeld
FRONTIERS IN NUTRITION
(2020)
Article
Medicine, General & Internal
Cecilia V. Tapia, Campos Marcia, Mora Ivone, Pozas Nadia, Morales Lesly, Guzman Camila, Aguilera Valentina, Ibarra Paula, Magne Fabien
Summary: A study compared saliva, nasal mid-turbinate swab, and nasopharyngeal swab samples in 112 ambulatory patients suspected of COVID-19, finding that while saliva samples had lower sensitivity for SARS-CoV-2 detection compared to NP swabs, they could be an interesting alternative sampling method when NP swabs cannot be collected.
FRONTIERS IN MEDICINE
(2021)
Article
Nutrition & Dietetics
Boopalan Ramasamy, Fabien Magne, Sujit Kumar Tripathy, Giriprasad Venugopal, Diptasree Mukherjee, Ramadass Balamurugan
Summary: In this study, specific bacterial species were found in vitamin D deficient patients, with or without KOA, indicating a potential association between gut microbiome composition, vitamin D, and knee osteoarthritis.
Article
Multidisciplinary Sciences
Susana A. Pesoa, Nestor Portela, Eduardo Fernandez, Osvaldo Elbarcha, Martin Gotteland, Fabien Magne
Summary: Accumulated evidence shows that genetic and environmental factors contribute to obesity, with gut microbiota playing a critical role in metabolism regulation and the development of chronic diseases. The study used high throughput sequencing to identify microbial differences in obese individuals from Argentina, US, and UK, revealing distinct microbiotypes and metabolic pathway signatures. This indicates that personalized strategies for managing obesity based on microbiome configuration could be promising.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Susana Ruiz-Ruiz, Carolina A. Ponce, Nicole Pesantes, Rebeca Bustamante, Gianna Gatti, Viviana San Martin, Mireya Gutierrez, Pamela Borquez, Sergio L. Vargas, Fabien Magne, Enrique J. Calderon, Vicente Perez-Brocal, Andres Moya
Summary: A new real-time PCR assay using SYBR Green has been developed for the detection of low levels of Pneumocystis jirovecii with higher sensitivity. This assay targets two regions simultaneously using two primer sets, and it has been found to be more rapid and simpler compared to the current nested-PCR methods. The new assay was able to detect P. jirovecii in samples that were negative for both rounds of nested-PCR, demonstrating its ability to detect low levels of the pathogen.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Saurav Sarkar, Fabien Magne, Giriprasad Venugopal, Suvendu Purkait, Naresh V. R. Mutha, Rituparna Maiti, Prity Sharma, Balamurugan Ramadass
Summary: The study found that using manuka honey as a prebiotic treatment can improve clinical symptoms and nasal microbiome composition in patients with atrophic rhinitis. After treatment with manuka honey, endoscopic scores and clinical symptoms improved, with decreased inflammation, restoration of mucus glands, and increased expression of GPR43 in the nasal cavities.
Letter
Nutrition & Dietetics
Martin Gotteland, Fabien Magne
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2017)
Meeting Abstract
Infectious Diseases
S. L. Vargas, C. A. Ponce, F. Magne, R. Bustamante, M. Gallo, V. San Martin, M. Gutierrez-Mejias, P. Borquez, K. Hananias
