Article
Agriculture, Dairy & Animal Science
Boin Lee, Jae-Yeong Kim, Young-Min Choi
Summary: This study investigated the association between the expression levels of apoptosis-related molecules and tenderness variation in Hanwoo beef. The results showed that the combination of apoptotic and anti-apoptotic factors at 45 min post-mortem were associated with beef tenderness attributes. However, the impact of these factors on tenderness diminished at 24 h post-mortem.
Article
Agriculture, Dairy & Animal Science
Fernand Jocelin Ngando, Xiangyan Zhang, Hongke Qu, Changquan Zhang, Fengqin Yang, Yakai Feng, Yanjie Shang, Sile Chen, Lipin Ren, Yadong Guo
Summary: This research investigated the life history and development rate of Sarcophaga crassipalpis under changing temperatures. Pteridine from the head was used to assess adult age grading. The results showed that the life history and development rate of S. crassipalpis were similar under changing temperatures compared to a fixed temperature of 25℃. The pteridine content in the head varied across different temperatures.
Article
Cell Biology
Yi-Fei Zhang, Lu Zhou, Han-Qing Mao, Fu-Hua Yang, Zhi Chen, Lu Zhang
Summary: The study found that cytosolic mtDNA regulates odontoblast inflammation through GSDMD-mediated pyroptosis, while STING-dependent inflammation may serve as a compensatory mechanism to control GSDMD-mediated pyroptosis, promoting the immune inflammatory response. These findings provide important clues to understand the role of mtDNA-GSDMD-STING in regulating odontoblast inflammation.
CELL DEATH DISCOVERY
(2021)
Article
Microbiology
Madeline M. Vroom, Angel Troncoso-Garcia, Alexandrea A. Duscher, Jamie S. Foster
Summary: The study found that modeled microgravity alters the apoptotic cell death process induced by beneficial microbes, by increasing the activity of caspases. However, this increase can be mitigated by using caspase inhibitors, which may have implications for maintaining animal-microbial homeostasis in spaceflight.
Article
Biochemistry & Molecular Biology
Fatma A. M. Mohamed, Hesham A. M. Gomaa, O. M. Hendawy, Asmaa T. Ali, Hatem S. Farghaly, Ahmed M. Gouda, Ahmed H. Abdelazeem, Mostafa H. Abdelrahman, Laurent Trembleau, Bahaa G. M. Youssif
Summary: The new series of EGFR inhibitors showed promising antiproliferative activity against cancer cell lines, with para-substituted phenethyl derivatives displaying superior activity. Some compounds also exhibited potential EGFR inhibitory activity, modulation of apoptosis-related proteins, and cell cycle arrest effects.
BIOORGANIC CHEMISTRY
(2021)
Article
Cell Biology
Negar Ghorbani, Roham Yaghubi, Jamshid Davoodi, Sara Pahlavan
Summary: Caspases are important proteases involved in cellular events such as apoptosis and inflammation. They also have non-apoptotic pro-survival functions, which are crucial in processes like cell proliferation, differentiation, and migration, as well as tumor metastasis and chemotherapy resistance. Understanding the mechanisms that regulate caspase activities is important for both mechanistic and clinical purposes. Additionally, the functions of apoptotic caspases are affected by various post-translational modifications.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Luying Shao, Miguel A. Gonzalez-Cardenete, Jose M. Prieto-Garcia
Summary: This study demonstrates that the derivatisation of ferruginol into 18-aminoferruginol increases its antiproliferative activity and changes the apoptotic mechanism of its parent molecule, ferruginol, in SK-Mel-28 human malignant melanoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Kelvin K. Hui, Maya Latif, Chesa Dojo Soeandy, Shudi Huang, Christopher E. Rodgers, Andrew J. Elia, Jeffrey T. Henderson
Summary: Cisplatin-induced cell death in the developing CNS is highly dependent on caspase-3, and a delayed form of necroptosis-like cell death occurs. These findings suggest a coordinated regulation of genotoxic stress response in vivo.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Camila Castillo Ferrer, Kevin Berthenet, Gabriel Ichim
Summary: Recent studies have shown that apoptosis, traditionally believed to suppress tumors, may paradoxically promote tumor growth and metastasis in some cases. This phenomenon may be achieved through various mechanisms, including the interaction of apoptotic cells with their microenvironment and the abnormal roles of apoptosis effectors.
Article
Multidisciplinary Sciences
Farzaneh Ghazavi, Jelle Huysentruyt, Jordy De Coninck, Stephanie Kourula, Sofie Martens, Behrouz Hassannia, Tim Wartewig, Tatyana Divert, Ria Roelandt, Bastian Popper, Andreas Hiergeist, Peter Tougaard, Tom Vanden Berghe, Marie Joossens, Geert Berx, Nozomi Takahashi, Adam Wahida, Peter Vandenabeele
Summary: Apoptosis is not essential for turnover of intestinal epithelial cells, maintenance of barrier function, microbiome, and immune cell composition during homeostasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Analytical
Yi An, Wei Gu, Minqian Miao, Jia Miao, Hui Zhou, Min Zhao, Yue Jiang, Qing Li, Qingqing Miao
Summary: To address the issue of early evaluation and prediction of the radiotherapy effect against tumors, researchers have developed a self-assembled organic probe that can activate near-infrared fluoro-photoacoustic signals for early evaluation and prediction of radiotherapy efficacy. The probe can undergo secondary assembly into larger nanoparticles in the presence of Casp-3 and simultaneously activate near-infrared fluoro-photoacoustic signals. This design enables precise prediction of the radiotherapy effect as early as 3 hours posttherapy.
ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Nathalie Tisch, Carmen Ruiz de Almodovar
Summary: The formation of new blood vessels involves proliferation of endothelial cells and vessel sprout elongation, along with vessel remodeling and regression to adapt vessel density. Recent studies focus on how vessel regression and cell death contribute to this process, challenging the simplistic view of cell death machinery as only promoting cellular demise. This review highlights the role of cell death signaling pathways, particularly apoptosis and necroptosis, in blood vessel formation during development and pathology.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Tian Xia, Ming Liu, Quan Zhao, Jian Ouyang, Bing Chen, Peipei Xu
Summary: PRMT5 is upregulated in multiple myeloma, and its inhibition enhances cell pyroptosis, while the expression of CASP1 negatively correlated with PRMT5 can be restored by suppressing PRMT5, promoting cell pyroptosis in MM.
CELL DEATH & DISEASE
(2021)
Article
Biophysics
Rumeysa Akcapinar, Canan Armutcu, Lokman Uzun
Summary: In this study, a nanoparticle-based sandwich-like immunoassay was developed for precise detection of apoptosis over caspase antibodies. By immobilizing antibodies onto magnetic and upconversion silica nanoparticles, this method overcomes the limitations of traditional apoptosis determination methods. The formation of sandwich-like complexes was successfully observed, and the upconversion emission intensity varied significantly depending on the amounts of caspase proteins. As a quantitative and promising alternative to benchmark apoptosis assays, this nanoparticle-based sandwich-like immunoassay demonstrates its potential for widespread application.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Chang-Hoon Hwang, Na-Kyoung Lee, Hyun-Dong Paik
Summary: Recent research has focused on the anti-cancer properties of Lactobacillus strains isolated from fermented foods. The study found that their anti-cancer effects are achieved by inducing apoptosis in cancer cells. However, consuming living organisms can lead to sepsis, especially in cancer patients with reduced immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)