Article
Chemistry, Medicinal
Xiu-Qiao Zhou, Xiao-Mei Mao, Rui Fan, Si-Yang Li, Jin Shang, Tong Zhang, Rui-Han Li, Hui-Qi Li, Yang Hui, Wen-Hao Chen, Zhan-Xiang Wang, Dong-Yan Shen
Summary: TBB, a compound extracted from Wedelia trilobata flowers, exhibits significant anti-tumor effects on HCC cells, inhibiting cell growth, inducing apoptosis, arresting cell cycle, and regulating protein expression levels. It effectively suppresses tumor growth in xenograft models without causing overt toxicity to healthy tissues.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Xue Hu, Fangzhou Jiao, Lan Zhang, Yingan Jiang
Summary: Liver cancer is a common malignancy with drug resistance being a major challenge in treatment. This study demonstrates that Dihydrotanshinone (DHTS) can inhibit the growth of hepatocellular carcinoma by suppressing the JAK2/STAT3 signaling pathway, suggesting its potential as a chemotherapeutic agent.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Junnv Xu, Haifeng Lin, Gang Wu, Mingyue Zhu, Mengsen Li
Summary: IL-6 plays a crucial role in the occurrence and development of hepatocellular carcinoma (HCC), and targeting the IL-6/STAT3 signaling pathway is essential for therapy. Several inhibitors of IL-6/STAT3 have been developed for cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Iuliana Nenu, Teodora Maria Toadere, Ioan Topor, Andra Tichindeleanu, Daniela Andreea Bondor, Serban Ellias Trella, Zeno Sparchez, Gabriela Adriana Filip
Summary: This review explores the dual nature of interleukin-6 (IL-6) in hepatocellular carcinoma (HCC), highlighting its roles as both a promoter and inhibitor of disease progression. It emphasizes the importance of understanding IL-6 signaling in HCC for tailored therapeutic strategies and discusses future research directions.
Article
Chemistry, Analytical
Wu-Yingzheng Guo, Rong-Rong Li, Yi-Xuan Fu, Shi-Yu Liu, Guo-Zhen Liu, Wen-Chao Yang, Guang-Fu Yang
Summary: PGP-I, identified as a novel inflammatory cytokine, is found to be involved in the development of HCC and could serve as a potential biomarker and therapeutic target for HCC. Bioimaging with a specific biosensor revealed aberrant expression of PGP-I in HCC cells, leading to tumor progression.
ANALYTICAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Chen Sun, Ming Bai, Weiwei Ke, Xiaoxun Wang, Xiangxuan Zhao, Zaiming Lu
Summary: The study demonstrated that XL888 can promote apoptosis of HCC cells induced by heat both in vitro and in vivo by affecting the expression of relevant proteins. This suggests a potential new combination strategy to enhance the efficiency of RFA.
Article
Biology
Chakrabhavi Dhananjaya Mohan, Min Hee Yang, Shobith Rangappa, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Amudha Deivasigamani, Kam Man Hui, Gautam Sethi, Kanchugarakoppal S. Rangappa, Kwang Seok Ahn
Summary: This study demonstrates that 3-formylchromone inhibits the activated STAT3 signaling in hepatocellular carcinoma cells and effectively reduces tumor growth and metastasis in a mouse model. The researchers also found that 3-formylchromone does not cause substantial toxicity. Therefore, it has the potential to be a powerful agent for targeting STAT3 signaling in hepatocellular carcinoma.
Article
Cell Biology
Zhi Yu, Dan Wang, Yingying Tang
Summary: In hepatocellular carcinoma, PKM2 promotes metastasis and inhibits autophagy through the activation of the JAK/STAT3 pathway. Knockdown of PKM2 induces cell apoptosis and autophagy, while also suppressing cell migration and proliferation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Chakrabhavi Dhananjaya Mohan, Chulwon Kim, Kodappully Sivaraman Siveen, Kanjoormana Aryan Manu, Shobith Rangappa, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Alan Prem Kumar, Kwang Seok Ahn
Summary: Crocetin inhibits STAT3 activation in HCC cells and affects the expression of multiple genes associated with cancer, thereby suppressing cell proliferation and invasive capacity.
Article
Biochemistry & Molecular Biology
Hyungjin Kim, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Chi-Hoon Ahn, Su-Yeon Park, Eungyeong Jang, Bonglee Kim, Sung-Hoon Kim
Summary: The study found that CB-PIC exerts an apoptotic effect by inhibiting the Warburg effect mediated by STAT3, thereby showing anticancer activity against hepatocellular carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ruiyuan Jiang, Shujuan Luo, Meng Zhang, Wei Wang, Shaoyuan Zhuo, Yajing Wu, Qingmei Qiu, Yuan Yuan, Xiao Jiang
Summary: This study aimed to investigate the effects of Ginsenoside Rh4 on inflammation-related hepatocellular carcinoma progression and the underlying mechanism. The results showed that Rh4 restricted the viability and proliferation of HCC cells and reduced their migration and invasion abilities. Rh4 also decreased the levels of glucose and lactic acid, and regulated the expression of proteins related to migration, glycolysis, and HDAC4/IL-6/STAT3 signaling. The study found that Rh4 could suppress inflammation-related HCC progression by targeting HDAC4/IL-6/STAT3 signaling.
MOLECULAR GENETICS AND GENOMICS
(2023)
Article
Medical Laboratory Technology
Eman H. Yousef, Nada F. Abo El-Magd, Amal M. El Gayar
Summary: This study evaluates the ability of norcantharidin (NCTD) to improve the efficacy of sorafenib (Sora) in hepatocellular carcinoma (HCC). The results show that NCTD enhances the activity of Sora against HCC and potentiates Sora-induced oxidative stress, tumor immunity reactivation, and attenuation of angiogenesis and metastasis. NCTD also suppresses drug resistance and stemness, and boosts Sora's antiproliferative and apoptotic activities.
TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Il Je Cho, Jae Kwang Kim, Eun Ok Kim, Sang Mi Park, Sang Chan Kim, Sung Hwan Ki, Sae Kwang Ku
Summary: HsA, a compound isolated from H. lyrata, exhibits cytotoxic effects on HCC cells through inducing apoptosis, increasing oxidative stress, and inhibiting STAT3 transactivation, thereby enhancing sensitivity to conventional chemotherapeutic agents like sorafenib.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yabing Hu, Yongchu Huang, Xiaohang Xie, Longshan Li, Yong Zhang, Xiaochao Zhang
Summary: In this study, we found that high expression of ARF6 is associated with poor prognosis and promotes the proliferation of hepatocellular carcinoma (HCC). ARF6 was upregulated in HCC tissues and correlated with poor tumor differentiation, incomplete tumor encapsulation, advanced tumor TNM stage, and poor prognosis. ARF6 activated the STAT3 signaling pathway to enhance HCC cell proliferation and tumor growth. These findings suggest that ARF6 may serve as a potential prognostic and therapeutic target for HCC patients.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Tongzhou Liang, Taiqiu Chen, Jincheng Qiu, Wenjie Gao, Xianjian Qiu, Yuanxin Zhu, Xudong Wang, Yanbo Chen, Hang Zhou, Zhihuai Deng, Pengfei Li, Caixia Xu, Yan Peng, Anjing Liang, Peiqiang Su, Bo Gao, Dongsheng Huang
Summary: Evidence suggests that ROR alpha plays a crucial role in cartilage development and OA pathogenesis by regulating the expression of cartilage matrix components. Blocking ROR alpha can reverse cartilage damage and elevate the expression of cartilage matrix components. Additionally, ROR alpha affects the IL-6/STAT3 signaling pathway, highlighting its potential as a treatment target in OA therapy.
CELL DEATH & DISEASE
(2021)
Article
Hematology
Lapo Alinari, Kiran V. Mahasenan, Fengting Yan, Vrajesh Karkhanis, Ji-Hyun Chung, Emily M. Smith, Carl Quinion, Porsha L. Smith, Lisa Kim, John T. Patton, Rosa Lapalombella, Bo Yu, Yun Wu, Satavisha Roy, Alessandra De Leo, Stefano Pileri, Claudio Agostinelli, Leona Ayers, James E. Bradner, Selina Chen-Kiang, Olivier Elemento, Tasneem Motiwala, Sarmila Majumder, John C. Byrd, Samson Jacob, Said Sif, Chenglong Li, Robert A. Baiocchi
Article
Biochemistry & Molecular Biology
Zhe Wang, Gaozhi Chen, Linfeng Chen, Xing Liu, Weitao Fu, Yali Zhang, Chenglong Li, Guang Liang, Yuepiao Cai
MOLECULAR BIOSYSTEMS
(2015)
Article
Biochemistry & Molecular Biology
Zhe Wang, Peng Zou, Chenglong Li, Wenfei He, Bing Xiao, Qilu Fang, Wenbo Chen, Suqing Zheng, Yunjie Zhao, Yuepiao Cai, Guang Liang
Article
Engineering, Biomedical
Wei Rao, Wujie Zhang, Izmarie Poventud-Fuentes, Yongchen Wang, Yifeng Lei, Pranay Agarwal, Benjamin Weekes, Chenglong Li, Xiongbin Lu, Jianhua Yu, Xiaoming He
ACTA BIOMATERIALIA
(2014)
Meeting Abstract
Oncology
Hui Xiao, Yang Bian, Chengguang Zhao, Li Lin, David Jou, Huameng Li, Chenglong Li, Jiayuh Lin
Meeting Abstract
Oncology
Jennifer Yang, Kaitlin Keenan, Thomas Mace, Tanios Bekaii-Saab, James Fuchs, Eric Schwartz, Chenglong Li, Jiayuh Lin, Pui-Kai Li, Gregory Lesinski
Article
Oncology
Fengting Yan, Lapo Alinari, Mark E. Lustberg, Ludmila Katherine Martin, Hector M. Cordero-Nieves, Yeshavanth Banasavadi-Siddegowda, Selene Virk, Jill Barnholtz-Sloan, Erica Hlavin Bell, Jeffrey Wojton, Naduparambil K. Jacob, Arnab Chakravarti, Michal O. Nowicki, Xin Wu, Rosa Lapalombella, Jharna Datta, Bo Yu, Kate Gordon, Amy Haseley, John T. Patton, Porsha L. Smith, John Ryu, Xiaoli Zhang, Xiaokui Mo, Guido Marcucci, Gerard Nuovo, Chang-Hyuk Kwon, John C. Byrd, E. Antonio Chiocca, Chenglong Li, Said Sif, Samson Jacob, Sean Lawler, Balveen Kaur, Robert A. Baiocchi
Article
Biochemistry & Molecular Biology
Hui Xiao, Hemant Kumar Bid, David Jou, Xiaojuan Wu, Wenying Yu, Chenglong Li, Peter J. Houghton, Jiayuh Lin
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Chemistry, Medicinal
Huameng Li, Hui Xiao, Li Lin, David Jou, Vandana Kumari, Jiayuh Lin, Chenglong Li
JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Article
Biochemical Research Methods
William Harvey, In-Hee Park, Oliver Ruebel, Valerio Pascucci, Peer-Timo Bremer, Chenglong Li, Yusu Wang
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2014)
Article
Biochemistry & Molecular Biology
Mu Zhang, Shengyan Xiang, Heui-Yun Joo, Lei Wang, Kendra A. Williams, Wei Liu, Chen Hu, Dan Tong, Joshua Haakenson, Chuangui Wang, Shengping Zhang, Ryan E. Pavlovicz, Amanda Jones, Kristina H. Schmidt, Jinfu Tang, Huiqin Dong, Bin Shan, Bin Fang, Rangasudhagar Radhakrishnan, Peter M. Glazer, Patrick Matthias, John Koomen, Edward Seto, Gerold Bepler, Santo V. Nicosia, Jiandong Chen, Chenglong Li, Liya Gu, Guo-Min Li, Wenlong Bai, Hengbin Wang, Xiaohong Zhang
Article
Chemistry, Organic
Wenying Yu, Chenglong Li
Meeting Abstract
Pediatrics
L. Liu, I Park, Y. Fan, M. T. Bakey, J. R. Carver, E. F. Kirby, S. N. Chettiar, N. Regan, D. Bhasin, P. Li, E. J. Sorscher, C. Li, X. R. Wang
PEDIATRIC PULMONOLOGY
(2014)
Article
Oncology
Tae-Dong Kim, James R. Fuchs, Eric Schwartz, Dalia Abdelhamid, Jonathan Etter, William L. Berry, Chenglong Li, Michael A. Ihnat, Pui-Kai Li, Ralf Janknecht
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2014)
Meeting Abstract
Cell Biology
Thomas D. Schmittgen, Dhruvitkumar S. Sutaria, Jinmai Jiang, Ola A. Elgamal, Ana Clara Azevedo-Pouly, Ryan Pavlovicz, Chenglong Li, Mitch A. Phelps
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2014)