期刊
APOPTOSIS
卷 16, 期 3, 页码 209-220出版社
SPRINGER
DOI: 10.1007/s10495-010-0571-z
关键词
Apoptosis; Innate immunity; Necrosis; Death domain; Molecular structure; Protein interaction
资金
- ministry of Education, Science and Technology [2010-0020962]
- National Research Foundation of Korea [2010-0020962] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The death domain (DD), which is a versatle protein interaction module, is the prime mediator of the interactions necessary for apoptosis, innate immunity and the necrosis signaling pathway. Because DD mediated signaling events are associated with critical human diseases, studies in these areas are of great biological importance. Accordingly, many biochemical and structural studies of DD have been conducted in the past decade to investigate apoptotic and innate immune signaling. Evaluation of the molecular structure of DD and their interactions with partners have shown the underlying molecular basis for the assembly of DD mediated complexes and for the regulation of apoptosis and innate immunity. This review summarizes the structure and function of various DDs and DD:DD complexes involved in those signaling pathways.
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