Article
Multidisciplinary Sciences
Alexandra Born, Janne Soetbeer, Morkos A. Henen, Frauke Breitgoff, Yevhen Polyhach, Gunnar Jeschke, Beat Voegeli
Summary: Pin1 is a cell regulator with two domains. Ligand binding can change the conformation of these domains, thus affecting its catalytic site.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Huadi Shi, Fulan Zhong, Xiaoqiong Yi, Zhenyi Shi, Feiyan Ou, Yufang Zuo, Zumin Xu
Summary: A prognostic model based on 3 peptidyl prolyl cis-trans isomerase gene signatures was constructed for hepatocellular carcinoma patients. The model showed that patients in the high-risk score group had a worse prognosis, and the validation results were consistent with the training set. A nomogram incorporating clinical stage and risk score was established with a well-matched calibration curve.
FRONTIERS IN GENETICS
(2021)
Article
Immunology
Nikhil Ponnoor Anto, Amitha Muraleedharan, Pulak Ranjan Nath, Zuoming Sun, Chen Keasar, Etta Livneh, Alex Braiman, Amnon Altman, Kok-Fai Kong, Noah Isakov
Summary: Protein kinase C-α (PKC-α) is selectively expressed in T lymphocytes and plays a crucial role in T cell activation and proliferation. The phosphorylation of Thr(335)-Pro residue in the regulatory domain of PKC-α is important for its activation and localization at the immunological synapse. The peptidyl-prolyl cis-trans isomerase Pin1 interacts with PKC-α through the phosphorylated Thr(335)-Pro motif, and this interaction is involved in early activation events in TCR-triggered T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yi-Ting Wang, Wan-Yi Hsiao, Shao-Win Wang
Summary: Pin1 regulates the structure and function of eukaryotic RNA polymerase II through interaction with Rpb1 in response to oxidative stress, facilitating transcription elongation. Elevated Pin1 levels in cancer cells may help sustain survival under oxidative stress. These findings suggest a conserved function of Pin1 in cellular response to oxidative stress among eukaryotic cells with potential clinical implications.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Cell Biology
Yew Mun Lee, Deryn En-Jie Teoh, Kay Yeung, Yih-Cherng Liou
Summary: Pin1 plays a crucial role in various diseases, particularly in neurodegenerative diseases and cancer. Its conservation across different species highlights its importance, and using different Pin1 models may provide insights for disease therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Physiology
Z. Z. Ge, Y. B. Wu, Z. Y. Xue, K. Zhang, R. X. Zhang
Summary: This study explored the therapeutic effects of the Pin1 inhibitor juglone on EAE in mice, showing that juglone significantly alleviated inflammation and demyelination in EAE and suppressed the expression of pathogenic T cells. The findings suggest that juglone has potential therapeutic benefits for autoimmune diseases and MS.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sakura Yoshida, Akinori Yamamoto, Hiroshi Masumoto, Takeshi Fuchigami, Akira Toriba, Mamoru Haratake, Morio Nakayama
Summary: Research indicates that selenium can be transported to the brain through alternative pathways independent of SELENOP, as even Selenop-knockout mice fed a diet containing adequate selenium do not exhibit neurological dysfunction observed in selenium-deficient diet-fed Selenop-knockout mice. This suggests that selenium from low-mass selenium-source compounds can be transported to the brain via alternative pathways.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2021)
Article
Plant Sciences
Ho-Hsiung Chang, Chia-Hwa Lee, Chung-Jan Chang, Fuh-Jyh Jan
Summary: In this study, a FK506-binding protein-type peptidyl-prolyl cis-trans isomerase NbFKPPIase was identified in Nicotiana benthamiana. It was found that NbFKPPIase plays a role in defense against begomoviruses and its expression is inhibited by begomoviral infection. The physical interaction between the viral movement protein MP and NbFKPPIase facilitates virus infection. Additionally, NbFKPPIase is regulated by plant hormones and involved in plant development.
MOLECULAR PLANT PATHOLOGY
(2022)
Review
Multidisciplinary Sciences
Gargi Biswas, Rahul Banerjee
Summary: PPIases are proteins that regulate cellular processes and play a key role in microbial pathogenesis. Human PPIases not only affect viral replication but also modulate host immune response. Targeting PPIases for COVID-19 treatment may alleviate human suffering.
Article
Cell Biology
Liqun Zhao, Steven H. Fong, Qiaoyun Yang, Yun-Jin Jiang, Vladimir Korzh, Yih-Cherng Liou
Summary: This study demonstrates that Pin1 plays a crucial role in regulating NeuroD protein levels during neuronal specification, highlighting its functional importance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Samia Bedouhene, Min Liu, Nassima Senani, Tarek Boussetta, Coralie Pintard, Pham My-Chan Dang, Jamel El-Benna
Summary: Neutrophils are important cells in the innate immune and inflammatory responses, but excessive activation can lead to tissue injury. The enzyme Pin1 plays a crucial role in neutrophil functions, and inhibiting its activity can affect the inflammatory response of neutrophils.
Article
Endocrinology & Metabolism
Yusuke Nakatsu, Takeshi Yamamotoya, Mizuki Okumura, Tetsuhiro Ishii, Mayu Kanamoto, Miki Naito, Mikako Nakanishi, Shunya Aoyama, Yasuka Matsunaga, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Tomoichiro Asano
Summary: Deleting the Pin1 gene in epiWAT promotes lipolysis and increases ATGL protein expression. Pin1 directly associates with ATGL, enhancing its degradation through the ubiquitin proteasome system. AdipoPin1 KO mice under a high fat diet exhibit higher lipolytic activity and improved glucose metabolism.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Otorhinolaryngology
Hailin Chen, Xuwei Cai, Baowen Du, Jianpiao Cai, Zhengzheng Luo
Summary: The study reveals that miR-150-5p regulates the malignant behavior of HEp-2 cells by targeting PIN1. miR-150-5p is down-regulated in LSCC tissues and HEp-2 cells, and it inhibits the proliferation and invasion of HEp-2 cells by regulating the expression of PIN1.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)
Article
Oncology
Keisuke Maeda, Makoto Habara, Mitsuyasu Kawaguchi, Hiroaki Matsumoto, Shunsuke Hanaki, Takahiro Masaki, Yuki Sato, Hideyasu Matsuyama, Kazuki Kunieda, Hidehiko Nakagawa, Midori Shimada
Summary: FKBP51 and FKBP52 are key regulators of prostate cancer cell growth, with the inhibition of AR dimer formation serving as a promising treatment strategy for prostate cancer.
MOLECULAR ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Jingyi Li, Chunfen Mo, Yifan Guo, Bowen Zhang, Xiao Feng, Qiuyue Si, Xiaobo Wu, Zhe Zhao, Lixin Gong, Dan He, Jichun Shao
Summary: Pin1, a member of the PPIases superfamily, catalyzes the cis-trans conversion of proline in target substrates to modulate cellular functions, and its dysregulation is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.