Article
Biochemistry & Molecular Biology
Su Bu, Anran Xiong, Zhiying Yang, Faycal Aissa-Brahim, Ying Chen, Yichun Zhang, Xunyong Zhou, Fuliang Cao
Summary: Bilobalide exhibits beneficial bioactivities such as neuroprotection, anti-inflammation, and antioxidant effects. The study demonstrates that bilobalide can induce apoptosis in mature adipocytes through the ROS-mediated mitochondrial pathway.
Review
Environmental Sciences
Abhishek Singh, Vishnu D. Rajput, Ragini Sharma, Karen Ghazaryan, Tatiana Minkina
Summary: Salinized land is spreading globally, threatening crop yields and the ability to feed a growing population. This review discusses the mechanisms of nano-enabled antioxidant enzyme-mediated plant tolerance to salt stress, including maintaining ROS homeostasis, enhancing ion retention and elimination, increasing nitric oxide production, signaling pathways, and reducing oxidative damage. Common techniques like protecting cells from oxidative stress and maintaining ionic balance are highlighted. The application and potential mechanisms of nanotechnology in salt tolerance of plants are also explored. The review aims to aid researchers in various fields to comprehend the potential of novel solutions for sustainable agriculture addressing salinity issues.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hayley C. Jackson, Carmen Pheiffer, Babalwa Jack, Donita Africander
Summary: This study provides an inexpensive model that mimics the characteristics of obesity by manipulating the time of adipocyte differentiation and increasing the glucose concentration. The results show that adipocyte hypertrophy, ROS production, IL-6 gene expression, lipolysis, and MCP1 gene expression are dependent on glucose and time. In addition, the hypertrophic model exhibits significantly higher expression of steroidogenic enzymes and enhanced conversion of cortisone and androstenedione. These characteristics make hypertrophic 3T3-L1 adipocytes an appropriate in vitro model to study adipocyte dysfunction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Ali Mahmoud El-Badri, Maria Batool, Ibrahim A. A. Mohamed, Zongkai Wang, Ahmed Khatab, Ahmed Sherif, Hasan Ahmad, Mohammad Nauman Khan, Hamada Mohamed Hassan, Ibrahim M. Elrewainy, Jie Kuai, Guangsheng Zhou, Bo Wang
Summary: Measuring metabolite patterns and antioxidant ability is crucial for understanding plant responses to salinity stress. Among five rapeseed cultivars, Yangyou 9 was identified as salt-tolerant, showing enhanced antioxidant enzyme activity and metabolite accumulation, leading to improved salt tolerance. This study provides valuable insights for breeding salt-tolerant rapeseed cultivars.
Review
Biochemistry & Molecular Biology
Agnieszka Gegotek, Elzbieta Skrzydlewska
Summary: This review highlights the importance of ascorbate as a strong antioxidant and its various mechanisms of action. It also emphasizes the interaction of ascorbate with other antioxidants and its role in promoting antioxidant proteins and transcription factors.
Article
Plant Sciences
Natasa Lukic, Frank M. Schurr, Tanja Trifkovic, Biljana Kukavica, Julia Walter
Summary: Transgenerational stress memory allows plants to respond to changing environments rapidly. However, the maternal stress experience does not pre-condition offspring to other types of stress. Transgenerational adaptive effects are linked to changes in the antioxidative system, reducing oxidative damage through upregulation of protective enzymes.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Nutrition & Dietetics
Xianfeng Deng, Bi Chen, Qin Luo, Xingru Zao, Haizhe Liu, Yongqiang Li
Summary: Hulless barley polyphenol (HBP) extract has the potential to inhibit obesity-related enzymes, prevent adipocyte differentiation, and attenuate adipogenesis, making it beneficial in preventing obesity.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Cordelia Mano John, Sumathy Arockiasamy
Summary: The study found that syringic acid significantly increased the levels of glutathione, superoxide dismutase, and catalase in mature adipocytes, and reduced ROS stress levels by inhibiting peroxide production and decreasing the expression of NADPH oxidase 4. It suggests that in addition to inhibiting adipogenesis, syringic acid can effectively reduce ROS stress in mature adipocytes by upregulating levels of intracellular antioxidants and decreasing levels of NOX4.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2021)
Article
Biochemistry & Molecular Biology
Woonghee Lee, Gwonhwa Song, Hyocheol Bae
Summary: Recent studies have identified obesity as one of the world's most serious chronic disorders. The regulation of adipogenesis through inhibiting adipogenic differentiation and reactive oxygen species (ROS) production has been selected as a strategy to treat obesity. Fraxetin, a major component extracted from the stem barks of Fraxinus rhynchophylla, has many bioactivities. The effects of fraxetin on adipogenesis and ROS production involve mitogen-activated protein kinase (MAPK) signaling pathways.
Article
Biochemistry & Molecular Biology
Anjar P. Asmara, Anchalee Prasansuklab, Anchalee Chiabchalard, Hui Chen, Alison T. Ung
Summary: Methanolic extracts from various parts of Acacia saligna showed significant antioxidant activities. These extracts and isolated compounds were able to reduce cellular reactive oxygen species (ROS) levels and maintain mitochondrial function in 3T3-L1 adipocytes. They also activated the AMPK signaling pathway and enhanced glucose uptake.
Article
Biochemistry & Molecular Biology
Lingli Zhao, Mengfei Zheng, Hao Cai, Juan Chen, Yan Lin, Fangbin Wang, Lu Wang, Xian Zhang, Jian Liu
Summary: This study evaluates the effects of six common dietary flavonoids on adipocyte differentiation in 3T3-L1 cells. It is found that flavonoids with the same backbone of 5,7-dihydroxylflavone can inhibit adipocyte differentiation, with luteolin exhibiting the strongest inhibitory capability. Luteolin reduces ROS generation during adipocyte differentiation, revealing a new mechanism underlying the anti-adipogenic actions of flavonoids.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Taotao Wang, Hong Xu, Yu Guo, Zhanming Li, Hua Ye, Liang Wu, Yuanxin Guo, Dongxu Wang
Summary: Perfluorodecanoic acid (PFDA) is a toxic persistent pollutant used in food packaging and cookware. Studies have shown that exposure to PFDA is associated with higher plasma triglyceride concentration in humans. This study investigated the effects and mechanisms of PFDA on lipid metabolism. The results demonstrated that PFDA promotes cellular triglyceride accumulation in a concentration-dependent manner and activates the NLRP3 inflammasome. Furthermore, PFDA-induced adipogenesis was mediated by the NLRP3 inflammasome and the SREBP1 pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Gizem Ece Derici, Sibel Ozdas, Ipek Canatar, Murat Koc
Summary: The study explored the potential anti-diabetic effects of B. spergulifolius extracts on 3T3-L1 adipocytes, showing reduced lipid accumulation, induced apoptosis, increased Glut-4 expression, and suppressed cell migration. These findings suggest that the extracts may contribute to reducing insulin-resistance in diabetes mellitus.
Article
Food Science & Technology
Yun-Fang Hao, Si-Wen Qin, Li Yang, Jian-Guo Jiang, Wei Zhu
Summary: The study found that marmin from Citrus maxima has anti-obesity effects, and can induce apoptosis of 3T3L1 preadipocytes through multiple pathways.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Medicine, Research & Experimental
Seong Hee Kang, Dong-Ho Bak, Seung Sik Lee, Hyoung-Woo Bai, Byung Yeoup Chung, Bo Sun Kang
Summary: The study demonstrated that centipedegrass extract (CGE) exhibited significant cytoprotective effects against H2O2-induced cell damage, reducing ROS levels and apoptotic protein expression. Additionally, CGE showed protective effects against intracellular ROS and radiation exposure, upregulating anti-apoptotic signals and downregulating pro-apoptotic signals. These results suggest that CGE may be an effective candidate for treating oxidative stress-related diseases and providing radioprotection.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)