Article
Chemistry, Multidisciplinary
Mingle Li, Kalayou Hiluf Gebremedhin, Dandan Ma, Zhongji Pu, Tao Xiong, Yunjie Xu, Jong Seung Kim, Xiaojun Peng
Summary: The article introduces a conditionally activatable photoredox catalysis method, which achieves more effective tumor treatment through site-specific photoredox. This approach enables control of photoresponsivity while ensuring biocompatibility and safety.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Bo Liu, Jingjing Li, Ping Zhou, Wei Pan, Na Li, Bo Tang
Summary: This study developed a nanoprobe based on the gold-selenium bond for fluorescence imaging of apoptotic signaling molecules in real-time, showing good specificity and stability. The probe can avoid interference from biological thiols and image the sequential changes of markers during cell apoptosis.
ANALYTICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Marina A. Semenova, Rita V. Chertkova, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh
Summary: Neuroglobin, a heme protein predominantly expressed in nervous tissue, has been shown to promote neuronal survival. However, the molecular mechanisms underlying its neuroprotective function remain unclear. Recent experimental and computational work suggests that the interaction between neuroglobin and mitochondrial cytochrome c may contribute to neuroglobin-mediated neuroprotection, both in the cytoplasm and within the mitochondria.
Article
Agriculture, Multidisciplinary
Bo Zou, Qianqian Yu, Lele Shao, Yingying Sun, Xingmin Li, Ruitong Dai
Summary: Lipid molecules play a crucial role in mitochondria-mediated apoptosis. This study reveals that the levels of mitochondrial lipids increase during early postmortem, accelerating apoptosis in beef muscle. The psoas major muscle has a higher degree of apoptosis and more severe muscle oxidation and antioxidant system damage compared to the longissimus lumborum muscle.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Armita Mahdavi Gorabi, Saeed Aslani, George E. Barreto, Eliana Baez-Jurado, Nasim Kiaie, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Neuroglobin, identified in 2000 in neurons of human and mouse nervous systems, is an oxygen-binding globin that provides protective effects against hypoxic/ischemic damage by promoting oxygen availability within the mitochondria. Impaired neuroglobin functioning has been linked to the pathogenesis of multiple neurodegenerative disorders. Studies have shown the potential of neuroglobin upregulation in improving neuroprotection through modulation of mitochondrial functions.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Xiao-pei Jiang, Shuai Jin, Weiting Shao, Lin Zhu, Shuanggen Yan, Jingtao Lu
Summary: Saponins of Marsdenia Tenacissima (SMT) have shown potential as an anticancer drug for liver cancer, inducing apoptosis in vitro and reducing tumor size in vivo.
Article
Immunology
Priyanka, Medha, Parul Bhatt, Hemant Joshi, Sadhna Sharma, Monika Sharma
Summary: Mitochondria are important for regulating cell fate, and Mycobacterium tuberculosis targets and controls host mitochondria for pathogenesis. In this study, the protein Rv0109 of Mtb was found to induce mitochondrial stress and apoptosis in macrophages.
MICROBIAL PATHOGENESIS
(2023)
Article
Neurosciences
Narjes Shahsavani, Arsalan Alizadeh, Hardeep Kataria, Soheila Karimi-Abdolrezaee
Summary: Nrg-1131 provides early neuroprotection in SCI by reducing oxidative stress, lipid peroxidation, necrosis, and apoptosis. Mechanistically, it protects neurons from cell death by modulating mitochondrial-associated apoptotic cascades, MAP kinase, and AKT signaling pathways.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Aikaterini Poulaki, Stavroula Giannouli
Summary: Mitochondrial double membrane lipids play a crucial role in maintaining mitochondrial health and apoptosis process. Understanding the physiological properties of mitochondrial membrane lipids is essential for cancer research and maintaining overall health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Zhuanxu Ouyang, Bijing Yang, Jiangnan Yi, Shanshan Zhu, Suge Lu, Yingwei Liu, Yangwei Li, Yuanliang Li, Khalid Mehmood, Riaz Hussain, Muhammad Ijaz, Jianying Guo, Zhaoxin Tang, Ying Li, Hui Zhang
Summary: This study revealed the harmful effects of sodium fluoride on liver tissues of ducks, including promoting apoptosis and altering the expression levels of key genes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Cell Biology
Elizabeth A. Thompson, Katherine Cascino, Alvaro A. Ordonez, Weiqiang Zhou, Ajay Vaghasia, Anne Hamacher-Brady, Nathan R. Brady, Im-Hong Sun, Rulin Wang, Avi Z. Rosenberg, Michael Delannoy, Richard Rothman, Katherine Fenstermacher, Lauren Sauer, Kathyrn Shaw-Saliba, Evan M. Bloch, Andrew D. Redd, Aaron A. R. Tobian, Maureen Horton, Kellie Smith, Andrew Pekosz, Franco R. D'Alessio, Srinivasan Yegnasubramanian, Hongkai Ji, Andrea L. Cox, Jonathan D. Powell
Summary: The study identifies a unique population of T cells expressing increased VDAC1 in severe and recovered COVID-19 patients, associated with mitochondrial dysfunction and apoptosis. Additionally, specific metabolic phenotypes of myeloid-derived suppressor cells in COVID-19 patients can distinguish between severe and mild disease. These findings offer insight into dysfunctional immune response in COVID-19 patients and potential for developing personalized therapeutic approaches.
Article
Cell Biology
Yin-zhao Jia, Jing Liu, Geng-qiao Wang, Hao Pan, Tie-zeng Huang, Ran Liu, Yong Zhang
Summary: HIGD1A, located on the inner membrane of mitochondria, regulates mitochondrial function to maintain cell survival under hypoxic conditions. It targets cytochrome c oxidase to affect ATP generation system and alter mitochondrial respiratory function. In different hypoxic regions of tumors, HIGD1A has distinct roles, promoting cell growth in mild and moderate hypoxia areas but inhibiting cell growth and retaining cellular activity in severe hypoxia areas. Understanding how HIGD1A regulates cell viability under hypoxic conditions can provide insights into tumor recurrence and drug resistance mechanisms, and suggest HIGD1A as a potential therapeutic target for hypoxia-related diseases.
Article
Biochemistry & Molecular Biology
Marco Fiocchetti, Patrizio Cracco, Emiliano Montalesi, Virginia Solar Fernandez, Jeffrey A. Stuart, Maria Marino
Summary: Dysfunctional mitochondria can have severe consequences on cell functions, especially in neurodegenerative diseases. The discovery of neuroglobin (NGB) as an endogenous neuroprotective protein provides potential for new therapeutic strategies, particularly in the context of mitochondrial homeostasis in neural pathologies.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Meng
Summary: The study demonstrated that lysionotin exhibited significant anti-liver cancer effects by potentially involving the caspase-3 mediated mitochondrial apoptosis pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cell Biology
Natalie Lorenz, Evert Jan Loef, Daniel J. Verdon, Chun-Jen J. Chen, Claudia J. Mansell, Catherine E. Angel, Anna E. S. Brooks, P. Rod Dunbar, Nigel P. Birch
JOURNAL OF LEUKOCYTE BIOLOGY
(2015)
Article
Sport Sciences
A. G. Storey, N. P. Birch, V. Fan, H. K. Smith
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2016)
Article
Cell Biology
Natalie Lorenz, Evert Jan Loef, Inken D. Kelch, Daniel J. Verdon, Moyra M. Black, Martin J. Middleditch, David R. Greenwood, E. Scott Graham, Anna E. S. Brooks, P. Rod Dunbar, Nigel P. Birch
IMMUNOLOGY AND CELL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Yong Cheng, Y. Peng Loh, Nigel P. Birch
JOURNAL OF MOLECULAR NEUROSCIENCE
(2017)
Article
Endocrinology & Metabolism
Niamh X. Cawley, Trushar Rathod, Sigrid Young, Hong Lou, Nigel Birch, Y. Peng Loh
MOLECULAR ENDOCRINOLOGY
(2016)
Review
Cell Biology
Tet Woo Lee, Vicky W. K. Tsang, Evert Jan Loef, Nigel P. Birch
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Hui Ren, Nigel P. Birch, Vinod Suresh
Article
Biochemistry & Molecular Biology
Jin Ng, Harveen Kaur, Thomas Collier, Kevin Chang, Anna E. S. Brooks, Jane R. Allison, Margaret A. Brimble, Anthony Hickey, Nigel P. Birch
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Cell Biology
Evert Jan Loef, Anna E. S. Brooks, Natalie Lorenz, Nigel P. Birch, P. Rod Dunbar
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Cell Biology
Saem Mul Park, Anna E. S. Brooks, Chun-Jen J. Chen, Hilary M. Sheppard, Evert Jan Loef, Julie D. McIntosh, Catherine E. Angel, Claudia J. Mansell, Adam Bartlett, Jonathan Cebon, Nigel P. Birch, P. Rod Dunbar
Summary: The study found subtle but important differences in B-cell migration within human lymph nodes compared to mouse models, particularly in the expression of CXCL13 and S1P gradients. CXCL13 was prominently expressed at the follicular edge in human lymph nodes, and CD68(+)CD11c(+)PU.1(+) tingible body macrophages were identified as likely drivers of B-cell egress.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Physiology
Stefan G. Wette, Nigel P. Birch, Mattias Soop, Martina Zuegel, Robyn M. Murphy, Graham D. Lamb, Heather K. Smith
Summary: This study assessed the early changes in the expression of titin-linked putative mechanosensing proteins and associated myogenic regulatory factors in skeletal muscle after power resistance exercise in fed, resistance-trained men. The results suggest that Ankrd 1 and MLP play a potential role in the muscle remodeling process in individuals who regularly engage in this type of exercise.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Immunology
Evert J. Loef, Hilary M. Sheppard, Nigel P. Birch, P. Rod Dunbar
Summary: The study found that monocyte-derived dendritic cells exhibited chemotactic migration towards the CCL19 gradient, while T cells primarily responded to CCL19 with increased exploratory chemokinesis, indicating that CCR7 plays a role in optimizing T cell scanning of antigen-presenting cells in lymphoid tissues.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Evert J. Loef, Hilary M. Sheppard, Nigel P. Birch, P. Rod Dunbar
Summary: This study demonstrates that T cells express plasminogen receptors and can convert bound plasminogen to plasmin upon activation. The generated plasmin can cleave the chemokine CCL21 and enhance the chemotactic response of monocyte-derived dendritic cells. These findings suggest that plasminogen bound to migrating immune cells may modulate chemokine responses in peripheral tissues.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Johanes K. Kasim, Iman Kavianinia, Jin Ng, Paul W. R. Harris, Nigel P. Birch, Margaret A. Brimble
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)
Meeting Abstract
Immunology
N. P. Birch, N. Lorenz, E. J. Loef, I. D. Kelch, D. J. Verdon, M. M. Black, M. J. Middleditch, D. R. Greenwood, E. S. Graham, A. E. S. Brooks, P. R. Dunbar
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)