Article
Biochemistry & Molecular Biology
Sara R. D. Gamelas, Nuno M. M. Moura, Yvette Habraken, Jacques Piette, Maria G. P. M. S. Neves, Maria A. F. Faustino
Summary: Photodynamic therapy (PDT) is an alternative method for treating cancer, with certain porphyrin derivatives showing higher efficiency than traditional drugs. In MCF-7 cells, cationic porphyrin 3 was found to be an effective photosensitizer. The study also revealed that cell death induced by the photodynamic process is caused by autophagic flux and necrosis.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Elzbieta Ostasnka, David Aebisher, Dorota Bartusik-Aebisher
Summary: Photodynamic Therapy (PDT) is a well-known alternative cancer treatment that relies on light activation of a photosensitizer in the presence of oxygen to induce cytotoxic effects in cancer cells. Proper light delivery and the selection of an appropriate photosensitizer are crucial for the effectiveness of PDT in treating cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Medicinal
Ravindra R. Cheruku, Steven G. Turowski, Farukh A. Durrani, Walter A. Tabaczynski, Joseph Cacaccio, Joseph R. Missert, Leslie Curtin, Sandra Sexton, Ronald Alberico, Craig M. Hendler, Joseph A. Spernyak, Zachary Grossman, Ravindra K. Pandey
Summary: In this study, a tumor-avid chlorophyll a derivative, HPPH, currently undergoing clinical trials, was conjugated with Gd(III)tetraxetan (DOTA) moieties to create a conjugate with potential for both tumor imaging and photodynamic therapy (PDT). The conjugate showed tumor specificity and low organ toxicity in mice, indicating its potential as a cancer imaging and treatment agent.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Gankun Yuan, Qilu Wang, Kunshan Huang, Jinping Xue, Juanjuan Chen
Summary: This study synthesized a novel aromatase-targeted photosensitizer, EX-Pc, by combining exemestane and a phthalocyanine photosensitizer. The compound exhibited high selectivity and affinity for breast cancer cells and tumor tissues with overexpression of aromatase, and showed significant photocytotoxicity and tumor regression ability. It has the potential to be a strategy for the treatment of postmenopausal breast cancer.
Review
Nanoscience & Nanotechnology
Jianhua Zou, Ling Li, Zhen Yang, Xiaoyuan Chen
Summary: Phototherapy combined with immunotherapy enhances the immunostimulating response and has synergistic effects for cancer treatment. Photoimmunotherapy (PIT) is a potential win-win strategy to prevent tumor metastases and recurrence by inducing immunogenic cell death (ICD).
Review
Medicine, Research & Experimental
Magdalena Czarnecka-Czapczynska, David Aebisher, Piotr Oles, Barbara Sosna, Magdalena Krupka-Olek, Klaudia Dynarowicz, Wojciech Latos, Grzegorz Cieslar, Aleksandra Kawczyk-Krupka
Summary: Breast cancer is a common cancer affecting women, with various treatment methods available. Photodynamic therapy, utilizing monochromatic light to activate photosensitizers for ROS production, is a minimally invasive treatment option.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Banendu Sunder Dash, Suprava Das, Jyh-Ping Chen
Summary: PSs have theranostic capabilities for cancer treatment through generating singlet oxygen and/or thermal heat. UV-Vis dyes are used for PDT, but have limited tissue penetration depth. NIR PSs like ICG and its derivatives have been introduced for cancer therapy by combining PTT and/or PDT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jiaxin Yan, Chunli Wang, Xiaomei Jiang, Yiqu Wei, Qun Wang, Kunli Cui, Xiao Xu, Feng Wang, Lei Zhang
Summary: Colorectal cancer is the third most commonly diagnosed malignancy and the second leading cause of cancer death worldwide. Photosensitizers play an important role in the treatment of CRC, but they are often associated with limitations.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Zongze Wu, Quan Liu, Swelm Wageh, Zhe Sun, Omar A. Al-Hartomy, Abdullah G. Al-Sehemi, Lesen Yan, Jiaojuan Chen, Wenjian Zhang, Jilin Yang, Han Zhang, Liping Liu
Summary: A smart photosensitive NiPS3 nanosheet was developed to address the issue of low oxygen content in solid tumors, which limits the efficacy of photodynamic therapy (PDT) against cancer.
Article
Chemistry, Physical
Wenbo Wu, Leilei Shi, Yukun Duan, Shidang Xu, Xihui Gao, Xinyuan Zhu, Bin Liu
Summary: A highly efficient metabolizable type-II photosensitizer with aggregation-induced emission characteristics was developed in this study, demonstrating good anti-tumor PDT efficiency in mouse models. Importantly, the photosensitizer can be gradually oxidized by endogenous hypochlorite after PDT and subsequently excreted through urine within 24 hours of administration.
CHEMISTRY OF MATERIALS
(2021)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes have great potential as photosensitizers for photodynamic therapy. The modular architectures of these complexes allow for tuning of various properties such as cellular uptake, subcellular targeting, solubility, and light absorption. Many studies focus on systematic variation of ligands to investigate their impact on photophysical and photobiological performance. However, comparisons between Ru(II)-based PSs and other generations of PSs are scarce. Nonetheless, quantitative models based on PDT dose metrics are available for qualitative comparisons. This review summarizes the relevant studies on Ru(II)-containing PSs and their potential efficacy.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes are promising photosensitizers for photodynamic therapy with potential in oncology and antimicrobial fields. These complexes can be tuned for different photophysical properties and studies comparing their efficacy to other PSs are limited but possible using PDT dose metrics.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Oncology
Xinning Wang, Dong Luo, James P. Basilion
Summary: Photodynamic therapy (PDT) is an effective treatment modality for cancers that uses harmless light to activate photosensitizers, targeting specific tumor cells to improve treatment efficacy and reduce toxicity to normal tissues. Recent advancements in targeted delivery of photosensitizers to cancer cells have shown promising results in enhancing PDT outcomes.
Review
Nanoscience & Nanotechnology
Huanyu Yang, Renfa Liu, Yunxue Xu, Linxue Qian, Zhifei Dai
Summary: Current clinical studies review the use of photodynamic therapy with nanoparticles in treating pancreatic cancer. Nanoparticles have advantages in improving the efficacy of photodynamic therapy for pancreatic cancer treatment. Challenges and future outlook in developing nanoparticle-based photodynamic therapy for pancreatic cancer are discussed.
NANO-MICRO LETTERS
(2021)
Article
Pharmacology & Pharmacy
Ayesha Loonat, Rahul Chandran, Janice Pellow, Heidi Abrahamse
Summary: This study investigates the effects of Thuja occidentalis homeopathic mother tincture and PDT on A549 lung cancer cells, and finds that both treatments have anticancer effects and can induce cell death. Moreover, the anticancer response is enhanced when the homeopathic mother tincture is activated by PDT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Longjie Zhong, Shubin Liu, Donglai Xu, Zhangming Zhu
Summary: This paper presents a MEMS capacitive accelerometer designed for IoT applications with an open-loop structure for low power consumption. The proposed weak feedback oversampling successive approximation readout circuit combines closed-loop hybrid dynamic amplifier with noise reduction technique to achieve low noise floor, high power efficiency, and high accuracy. Measurement results demonstrate a noise floor of 63 mu g/root Hz and an FoM of 14pJ for the fabricated circuit.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2023)
Article
Engineering, Electrical & Electronic
Yao Teng, Changqing Feng, Yi Liu, Chenfei Yang, Shubin Liu
Summary: Due to the change in operation mode of the DESY II test beam facility, the existing beam telescope built with Mimosa26 chips is unable to meet the requirements of the increased beam particle rate. This article presents a new beam telescope built with ALice Pixel Detector (ALPIDE) chips, originally designed for the ALICE upgrade. The use of gigabit Ethernet in the high-speed transceiver of Kintex FPGA allows individual data acquisition and control of each ALPIDE chip, enhancing beam utilization and reducing track reconstruction difficulty.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2023)
Article
Instruments & Instrumentation
Keqing Zhao, Changqing Feng, Shuwen Wang, Zhongtao Shen, Kan Zhang, Shubin Liu
Summary: In this study, a one-dimensional convolutional neural network (1D-CNN) is utilized to discriminate between neutrons and gamma rays detected by the Cs2LiYCl6: Ce3+(CLYC) crystal. Three different optimizers are used to train the CNN and the RMSProp optimizer yields the best performance. The CNN achieves an accuracy of 99.395% for the AmBe source, with false alarm rates (FARs) of only 0.003% and 0.020% for the gamma sources 137Cs and 22Na, respectively.
JOURNAL OF INSTRUMENTATION
(2023)
Review
Chemistry, Multidisciplinary
Xiaoyan An, Wenbiao Zhang, Chunying Rong, Shubin Liu
Summary: The Ramachandran plot is an important tool in biochemistry for visualizing the secondary structures of protein residues. This study used two different approaches, bioinformatics and molecular dynamics, to generate the plot. The analysis of the plot revealed that electrostatic interaction is the main contributor to the formation of secondary structures, while steric and exchange-correlation contributions play minor roles. These findings provide a deeper understanding of the nature and origin of secondary structure propensities from the Ramachandran plot.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2023)
Article
Chemistry, Medicinal
Han Wee Ong, Anna Truong, Frank Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy M. Havener, Michael Chirgwin, Kareem A. Galal, Caleb Willis, Andreas Kramer, Shubin Liu, Stefan Knapp, Emily R. Derbyshire, Reena Zutshi, David H. Drewry
Summary: Malaria is a global health problem with high morbidity and mortality rates. The emergence of drug resistance against current treatments emphasizes the need for alternative antimalarials. In this study, we discovered Ki8751 as an inhibitor of essential kinase PfPK6 and identified two compounds (67 and 79) with potent antiplasmodial activity against both blood and liver stages of malaria.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Fisheries
Zhe Yu, Qiang Hao, Shu-Bin Liu, Qing-Shuang Zhang, Xing-Yu Chen, Sheng-Hui Li, Chao Ran, Ya-Lin Yang, Tsegay Teame, Zhen Zhang, Zhi-Gang Zhou
Summary: Postbiotics, including metabolites, lysate extracts, cell wall components, and culture supernatants of probiotics, can exhibit significant prebiotic effects. SWFC, derived from the culture supernatant of Cetobacterium somerae and Lactococcus lactis, showed positive effects on the growth, health, and gut microbiota of Cyprinus carpio fed with high fat diets. SWFC improved various health indicators, reduced liver injury, and regulated gut health and immune responses. The supplementation of SWFC in aquatic animal feed can enhance fish health and balance gut microbiota.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Hongzhi Liang, Shubin Liu, Yi Shen, Jun Chang, Zhangming Zhu
Summary: This article presents a single-core broadband voltage-controlled oscillator (VCO) with a dual-mode variable inductor (VID). By using a magnetically coupled LC network with two independent switched-capacitor arrays, the VCO improves the frequency tuning range (FTR) by employing the wide inductance reconfigurable range of the X-type mode. The VCO also utilizes the low-quality factor (Q) degradation characteristic of the L-type mode for tuning bands calibration (TBC). The designed and fabricated VCO demonstrates low power dissipation and small die area in 65-nm CMOS technology.
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
(2023)
Article
Chemistry, Inorganic & Nuclear
Bin Wang, Chunying Rong, Ming Lei, Shubin Liu, Frank De Proft
Summary: Designing efficient and selective catalysts for carbon dioxide reduction is an active area of research in homogeneous catalysis. In this study, the catalytic activity of a newly reported Mn(I)-PNP-pincer catalyst with an embedded aromatic ring is investigated. The study systematically examines the catalyst's capability to yield different products and explores the importance of ligand aromaticity and steric effects on metal-ligand cooperativity. The reactivity of the catalyst is probed using conceptual density functional theory and an information-theoretic approach, leading to a novel partitioning of the reaction coordinate into three relevant regions. The results demonstrate that different properties govern the reactivity in these different regions, such as steric effects, electrophilicity/nucleophilicity, or aromaticity. The methodology and analytical tools employed in this study have the potential to be generalized and extended to other catalytic systems, offering insights towards designing improved catalysts.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Jiancheng Xu, Fenglin Kuang, Shubin Liu, Lei Li
Summary: We propose an electronically controlled optofluidic zoom imaging system combined with deep learning, which achieves a large continuous zoom change and a high-resolution image. The system consists of an optofluidic zoom objective and an image-processing module, and has a focal length range from 4.0 mm to 31.3 mm. Aberrations can be dynamically corrected by six electrowetting liquid lenses in the focal length range of 9.4 mm to 18.8 mm, while in the focal length range of 4.0-9.4 mm and 18.8-31.3 mm, deep learning is used to improve the image quality. The system has a zoom ratio of 7.8x and a maximum field of view of about 29 degrees, with potential applications in camera, telescope, and more.
Article
Nanoscience & Nanotechnology
Na Cao, Yanhua Li, Ruoyu Zhang, Shubin Liu, Yuping Xiong, Hui Cao
Summary: Due to its noninvasiveness, high resolution, and high sensitivity, photoacoustic imaging has rapidly developed in biomedicine. However, research on dermatosis detection using photoacoustic imaging is still lacking. This study models the skin as a multilayer planar medium and derives an analytical expression for the photoacoustic signal of multilayer skin tissue. The study also considers the influence of the number of skin layers on the photoacoustic signal, providing a comprehensive understanding of photoacoustic mechanisms in dermatosis tissues.
Article
Chemistry, Physical
Xin He, Tian Lu, Chunying Rong, Shubin Liu, Paul W. Ayers, Wenjian Liu
Summary: Considerable research interest has been observed in recent literature regarding the development and applications of information-theoretic approach (ITA) quantities in density functional theory. These ITA quantities are explicit density functionals with continuous and well-behaved local distributions in real space. By systematically analyzing the topological behavior of four representative ITA quantities, namely Shannon entropy, two forms of Fisher information, and relative Shannon entropy, our work further develops ITA. The topological analyses for 103 molecular systems provide new insights into bonding interactions and physiochemical properties, such as electrophilicity, nucleophilicity, acidity, and aromaticity. Comparisons with results from other functions demonstrate the potential of our results as a methodological approach and practical tool for elucidating chemical bonding and reactivity propensity.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Dongbo Zhao, Yilin Zhao, Xin He, Yunzhi Li, Paul W. Ayers, Shubin Liu
Summary: In this study, we demonstrate an efficient and accurate method for predicting the molecular response properties of condensed-phase systems under periodic boundary conditions. By combining the GEBF and ITA approaches, we establish linear relations between small subsystems and larger subsystems, allowing for the direct prediction of polarizabilities from the molecular wavefunction via ITA quantities. The proposed PBC-GEBF-ITA protocol shows good efficiency and transferability for periodic systems with hundreds of atoms in a unit cell.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
Article
Chemistry, Physical
Hao Hu, Weitao Yang, Shubin Liu
Summary: We propose an efficient method to calculate the electrostatic component of solvation free energy using the two-point Pade approximation. This method only requires two simulations to determine the Pade approximant and compute the corresponding free energy contribution, making it useful for applications where accurate but computationally expensive energy functions like quantum mechanics are used. The method accurately predicts the electrostatic solvation free energy for both neutral and charged species, as demonstrated by applications to several model systems.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
Article
Chemistry, Physical
Jorge Nochebuena, Jean-Philip Piquemal, Shubin Liu, G. Andres Cisneros
Summary: Understanding cooperativity and frustration is crucial for studying biological processes. This study evaluates the performance of different force fields in capturing cooperativity in neutral and charged molecular clusters. The results show that polarizable and nonpolarizable force fields qualitatively reproduce the relative cooperativity observed, but only the polarizable force field can describe absolute cooperativity.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
Article
Chemistry, Physical
Chunna Guo, Meng Li, Chunying Rong, Shubin Liu
Summary: Using density-based quantities to predict molecular reactivity is of interest in density functional theory, and recent developments in information-theoretic approach have represented this trend. In this contribution, a new representation of ITA quantities is introduced by approximating their partial derivatives with respect to the number of total electrons in a finite difference approximation. This work not only expands the theoretical framework of ITA but also provides new perspectives in dealing with molecular processes and chemical reactivity.
THEORETICAL CHEMISTRY ACCOUNTS
(2023)
