Article
Cell Biology
Youwen Tan, Yan Huang, Rong Mei, Fei Mao, Dakai Yang, Jinwen Liu, Wenrong Xu, Hui Qian, Yongmin Yan
Summary: This study reveals that the secreted exosomes from human umbilical cord mesenchymal stem cells can alleviate liver fibrosis by promoting ferroptosis in hepatic stellate cells. The mechanism involves the promotion of ferroptosis-like cell death, ROS formation, mitochondrial dysfunction, Fe-2(+) release, and lipid peroxidation, as well as the suppression of xCT-driven GPX4 expression by MSC-ex derived BECN1. This study highlights the potential of MSC-ex as a therapeutic strategy for liver fibrosis.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Jianhui Yang, Omar Aljitawi, Peter Van Veldhuizen
Summary: This review summarizes the recent research progress on the role of CD133 in prostate cancer stem cells (PCSC), including its selective expression in undifferentiated cells, its correlation to treatment resistance, its gene regulation and functional analysis, and its targeted therapy in vitro, in vivo, and in clinical trials.
Article
Cell Biology
Vincent De Smet, Nathalie Eysackers, Vincent Merens, Mina Kazemzadeh Dastjerd, Georg Halder, Stefaan Verhulst, Inge Mannaerts, Leo A. van Grunsven
Summary: Recent research has shown that both the initiation and activation transcriptional programs of hepatic stellate cells are active in mice and humans with chronic liver disease. This suggests that molecules involved in both phases are equally important in finding druggable targets for chronic liver disease.
CELL DEATH & DISEASE
(2021)
Article
Gastroenterology & Hepatology
Celia Short, Allen Zhong, Jiabo Xu, Elaa Mahdi, Alison Glazier, Nicolas Malkoff, Nicolas Noriega, Theresa Yeo, Kinji Asahina, Kasper S. Wang
Summary: This study found that Prom1-expressing hepatic progenitor cells (HPCs) expand in biliary atresia (BA), giving rise to cholangiocytes within biliary ductular reactions. The TWEAK/FN14 signaling pathway mediates HPC proliferation, leading to fibrogenesis in BA.
Article
Biochemistry & Molecular Biology
Dayane Mayumi Miyasaki, Alexandra Cristina Senegaglia, Sergio Adriane Bezerra de Moura, Amanda Leitolis, Luiz Guilherme Achcar Capriglione, Leticia Fracaro, Lidiane Maria Boldrini Leite, Paulo Henrique Utumi, Felipe Yukio Ishikawa Fragoso, Fernando Meyer, Alejandro Correa, Paulo Roberto Slud Brofman
Summary: This study evaluated the effects of extracellular vesicles (EVs) from human umbilical cord tissue and human umbilical cord blood on rats with chronic kidney disease. The results demonstrated that EVs have the potential to improve renal function, suggesting their use as a cell-free treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Zoe Boyer-Diaz, Peio Aristu-Zabalza, Maria Andres-Rozas, Claude Robert, Marti Ortega-Ribera, Anabel Fernandez-Iglesias, Pierre Broqua, Jean-Louis Junien, Guillaume Wettstein, Jaime Bosch, Jordi Gracia-Sancho
Summary: The study demonstrates that lanifibranor improves portal hypertension and liver fibrosis, two key elements of the pathophysiology of ACLD, in preclinical models of the disease. Evaluation of lanifibranor in liver cells from patients with ACLD further supports its beneficial effects.
JOURNAL OF HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ji Hye Jun, Soo Young Park, Sohae Park, Hee Jung Park, Jae Yeon Kim, Gyu Tae Park, Si Hyun Bae, Jae Ho Kim, Gi Jin Kim
Summary: The hexapeptide WKYMVm demonstrates antifibrotic and angiogenic effects in a rat model of bile duct ligation (BDL), showing a reduction in collagen type I and alpha-smooth muscle actin expression and an increase in angiogenetic factors. Furthermore, WKYMVm alleviates hepatic fibrosis by inhibiting hepatic stellate cell activation and promotes hepatic regeneration via vascular remodeling, making it a potential therapeutic agent for liver fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Rui Li, Jinhang Zhang, Qinhui Liu, Qin Tang, Qingyi Jia, Yimin Xiong, Jinhan He, Yanping Li
Summary: Activated hepatic stellate cells (HSCs) play a crucial role in the development of hepatic fibrosis. By targeting the increased fibronectin expression on HSCs, we developed PEGylated liposomes decorated with CREKA to deliver sorafenib specifically to activated HSCs. In vitro and in vivo experiments demonstrated that CREKA-coupled liposomes effectively suppressed HSC activation, collagen accumulation, inflammation, and angiogenesis. This targeted delivery system shows promising potential for the treatment of hepatic fibrosis.
ACTA BIOMATERIALIA
(2023)
Article
Immunology
Juliane Siqueira Francisco, Marcia Andrea Barge Loucao Terra, Gabriel Couto Thurler Klein, Barbara Cristina Euzebio Pereira Dias de Oliveira, Marcelo Pelajo-Machado
Summary: This study revisits extramedullary hematopoiesis in the peripheral zone of murine hepatic schistosomal granulomas using new technical and conceptual approaches. The findings suggest that hematopoietic cells proliferate around trapped parasite eggs in the liver and around hepatic vessels. The microenvironment with acidic and sulfated glycoconjugates, reticular fibers, and the absence of fibronectin is identified as crucial for the attraction and maintenance of hematopoiesis. The study provides valuable insights into the pathology of schistosomiasis and the dynamics of hematopoiesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Masateru Nomura, Joseph George, Chieko Hashizume, Takashi Saito, Yoshimichi Ueda, Yasuhito Ishigaki, Mutsumi Tsuchishima, Mikihiro Tsutsumi
Summary: In this study, the effects of human adipose derived stem cells (hADSCs) on experimentally induced hepatic fibrosis and early cirrhosis in rats were evaluated. The results showed that treatment with hADSCs significantly improved liver functions and reduced hepatic fibrosis and early cirrhosis.
MOLECULAR MEDICINE
(2022)
Article
Immunology
Fangming Yang, Heng Li, Yanmin Li, Yaokun Hao, Chenxiao Wang, Pan Jia, Xinju Chen, Suping Ma, Zhun Xiao
Summary: Hepatic fibrosis is a dynamic pathological process characterized by the accumulation of extra cellular matrix in chronic liver diseases, with activation of hepatic stellate cells (HSCs) playing a central role. Communication between hepatocytes and surrounding cells influences the activation of HSCs and the progression of fibrosis, highlighting the complexity and plasticity of HSC activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ryo Kanai, Ayumu Nakashima, Shigehiro Doi, Tomoe Kimura, Ken Yoshida, Satoshi Maeda, Naoki Ishiuchi, Yumi Yamada, Takeshi Ike, Toshiki Doi, Yukio Kato, Takao Masaki
Summary: Pre-treatment with IFN-gamma enhances the anti-fibrotic ability of MSCs, reducing inflammatory cell infiltration and improving interstitial fibrosis.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Chanbin Lee, Minju Kim, Jinsol Han, Myunghee Yoon, Youngmi Jung
Summary: Liver fibrosis is a common feature of chronic liver disease and regulating HSC activation is crucial for its treatment. MSCs interact directly with immune cells, HSCs, and hepatocytes to secrete modulators and reduce liver fibrosis. Both MSC itself and MSC modulators have shown anti-fibrotic functions, but the underlying mechanism is yet to be established.
Article
Cell & Tissue Engineering
Ahmed Abdel-Latif, Taha Ahmed, Steve W. Leung, Talal Alnabelsi, Wadea Tarhuni, Michael E. Sekela
Summary: This study aimed to examine the safety and feasibility of targeted transmyocardial laser revascularization therapy and autologous CD133 (+) progenitor cell therapy in patients with chronic ischemic cardiomyopathy. The results showed that the combined therapy was safe and demonstrated modest improvement in ischemic score in the short-term.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Environmental Sciences
Sally M. Khadrawy, Hanaa M. Mohamed, Ayman M. Mahmoud
Summary: This study demonstrated that BMSCs can ameliorate liver function, suppress oxidative stress and inflammation, enhance antioxidants, and prevent liver fibrosis through the Nrf2/HO-1 signaling pathway in rats with CCl4-induced liver damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Meeting Abstract
Urology & Nephrology
Hosni Salem, Amira Kamel, Tarek Aboushousha, Olfat Hammam, Ali El-Hindawi
JOURNAL OF UROLOGY
(2017)
Article
Public, Environmental & Occupational Health
Naglaa M. El-Lakkany, Walaa H. El-Maadawy, Sayed H. Seif el-Din, Olfat A. Hammam, Salwa H. Mohamed, Shahira M. Ezzat, Marwa M. Safar, Samira Saleh
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2017)
Article
Transplantation
Hanan El Baz, Zeinab Demerdash, Manal Kamel, Shimaa Atta, Faten Salah, Salwa Hassan, Olfat Hammam, Heba Khalil, Safa Meshaal, Inas Raafat
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2018)
Article
Medicine, Research & Experimental
Manal M. Kamel, Hanan G. El Baz, Zeinab Demerdash, Salwa Hassan, Faten Salah, Wafaa A. Mansour, Olfat Hammam, Shimaa Atta, Ali Bayoumi, Marwa Hassan, Soheir Mahmoud
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2018)
Article
Transplantation
Hanan El Baz, Zeinab Demerdash, Manal Kamel, Shimaa Atta, Faten Salah, Salwa Hassan, Olfat Hammam, Heba Khalil, Ali Bayoumi
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Yasmeen Attia, Rasha Tawfiq, Aya Adel, Abdullah Gibriel, Olfat Hammam, Mohamed Elmazar
JOURNAL OF HEPATOLOGY
(2019)
Article
Toxicology
W. H. El-Maadawy, O. A. Hammam, S. H. Seif el-Din, N. M. El-Lakkany
HUMAN & EXPERIMENTAL TOXICOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sohair Aly Hassan, Ali Mohamed El Hagrassi, Olfat Hammam, Abdelmohsen M. Soliman, Essam Ezzeldin, Wessam Magdi Aziz
Article
Toxicology
Sayed H. Seif El-Din, M. B. Salem, N. M. El-Lakkany, O. A. Hammam, S. M. Nasr, H. Okasha, L. A. Ahmed, S. Saleh, S. S. Botros
Summary: Early treatment with a combination of L. reuteri + MTZ in combination with MTF has been shown to be more effective in improving glucose and lipid metabolism, reducing liver dysfunction, alleviating oxidative stress and inflammation, promoting autophagy and apoptosis, and correcting gut dysbiosis in NAFLD rats.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Noha M. Badawi, Yasmeen M. Attia, Dina M. El-Kersh, Olfat A. Hammam, Maha K. A. Khalifa
Summary: This study aimed to design and optimize trans-cinnamic acid-loaded PLGA nanoparticles (CIN-PLGA-NPs) for inhibiting epithelial-mesenchymal transition (EMT) in triple-negative breast cancer. The optimized formulation showed high entrapment efficiency, stability, improved dissolution rate, and enhanced cytotoxicity against cancer cells. The nanoparticles effectively inhibited tumor cell migration and growth.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Medicinal
Eman S. El-Wakil, Hagar F. Abdelmaksoud, Majed H. Wakid, Muslimah N. Alsulami, Olfat Hammam, Haleema H. Albohiri, Marwa M. I. Ghallab
Summary: This study aimed to compare the antiparasitic and anticancer effects of Annona muricata leaves and FDA-approved drug nitazoxanide (NTZ) in immunosuppressed mice. The results showed that Annona muricata has reliable ability to treat Cryptosporidium and prevent the development of neoplastic seqeuls after infection.
Article
Chemistry, Multidisciplinary
Mohammed S. Ali, Rasha M. Hussein, Yasser Gaber, Olfat A. Hammam, Mohamed A. Kandeil
Article
Biochemistry & Molecular Biology
Tarek K. Motawi, Shohda A. El-Maraghy, Aliaa Nabil ElMeshad, Omnia M. Nady, Olfat A. Hammam
CHEMICO-BIOLOGICAL INTERACTIONS
(2017)
Article
Pharmacology & Pharmacy
Sanaa Sabet Botros, Naglaa Mohamed El-Lakkany, Olfat Ali Hammam, Abdel-Naser Abdel-Aal Sabra, Alaa Awad Taha
JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH
(2016)
Article
Integrative & Complementary Medicine
Naglaa M. El-Lakkany, Walaa H. El-Maadawy, Sayed H. Seif El-Din, Samira Saleh, Marwa M. Safar, Shahira M. Ezzat, Salwa H. Mohamed, Sanaa S. Botros, Zeinab Demerdash, Olfat A. Hammam
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2019)