期刊
APMIS
卷 116, 期 11, 页码 1020-1025出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1600-0463.2008.01012.x
关键词
Solitary fibrous tumour; kidney; S-100 protein; malignant; dedifferentiation
Solitary fibrous tumour (SFT) rarely occurs in the kidney, with only one case exhibiting malignant behaviour. We report the case of a typical SFT of the kidney with sarcomatous overgrowth in a 34-year-old woman. This malignant component, grossly apparent as a nodular area arising in the context of the main tumour mass, consisted of CD34(+) mitotically active atypical plump spindle- to epithelioid-shaped cells, including pleomorphic multinucleated giant cells. A novel immunohistochemical finding was diffuse and strong S-100 protein expression by sarcomatous cells. This should be kept in mind by pathologists to avoid confusion with other S-100 protein-positive malignant neoplasms.
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