Article
Medicine, General & Internal
Piotr Nehring, Grazyna Gromadzka, Milosz Jastrzebski, Adam Przybylkowski
Summary: This study provides the first insight into a potential connection between genetic variants in matrix metalloproteinases (MMPs) and colon diverticulosis. Specifically, allele T of MMP9 rs3918242 and allele 5A of MMP3 rs3025058 appear to be linked to this condition.
MEDICINA-LITHUANIA
(2023)
Article
Biochemistry & Molecular Biology
Ya-Tang Chiang, Yu-Bai Xiao, Shan-hui Hsu, Shu-Wei Chang, Chia-Ching Chou
Summary: Tannic acid (TA) has antibacterial, antioxidant, and anti-inflammatory properties and acts as an adhesive, hemostatic, and crosslinking agent in hydrogels. TA has been reported to inhibit MMP-2/- 9 activities, thereby improving tissue remodeling and wound healing. In this study, atomistic modeling was used to explore the mechanisms and structures of TA binding with MMP-2 and MMP-9, revealing the specific binding regions and molecular interactions involved. Understanding the binding mechanism and dynamics of TA with these MMPs provides crucial knowledge on the effects of TA on MMPs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Shinji Takai, Denan Jin
Summary: Chymase-activated MMP-9 is closely related to the pathogenesis of various diseases, especially inflammation-related diseases. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of these diseases. Chymase inhibitors attenuate MMP-9 formation and reduce inflammatory cell numbers, thereby ameliorating the development and progression of these disorders.
Review
Biochemistry & Molecular Biology
Zainab Ahmed Rashid, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs), especially MMP-9, play a significant role in cancer pathogenesis and progression. However, no effective MMP-9 inhibitor has been approved by the FDA. This review focuses on exploring the strategies for designing MMP-9 inhibitors and their anticancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Ionut Luchian, Mihaela Moscalu, Ancuta Goriuc, Ludovica Nucci, Monica Tatarciuc, Ioana Martu, Mihai Covasa
Summary: Periodontitis results in destructive effects on periodontium, with increased levels of MMP-9. Periodontal treatment alone or combined with orthodontic treatment can improve clinical parameters and lower MMP-9 levels. The degree of malocclusion affects the treatment's impact on MMP-9 levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Chemistry, Medicinal
Sanjib Das, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Obstetrics & Gynecology
Yi Zhou, Ran Wang, Shi-Xian Chen, Li-Sheng Wu, Jun-Qing Zhu
Summary: The study revealed that the variant genotype and allele of MMP9-1562 C/T are associated with an increased risk of HDP, particularly in the cases of preeclampsia and gestational hypertension.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Adam S. Kirosingh, Alea Delmastro, Abel Kakuru, Kattria van der Ploeg, Sanchita Bhattacharya, Kathleen D. Press, Maureen Ty, Lauren de la Parte, Jimmy Kizza, Mary Muhindo, Sebastien Devachanne, Benoit Gamain, Felistas Nankya, Kenneth Musinguzi, Philip J. Rosenthal, Margaret E. Feeney, Moses Kamya, Grant Dorsey, Prasanna Jagannathan
Summary: This study compared the cellular immune response between primigravid and multigravid women living in a malaria-endemic region. It found that primigravid women had a higher proportion of malaria-specific, non-naive CD4(+) T cells, which was associated with increased risks of parasitaemia during pregnancy and placental malaria.
Article
Biochemistry & Molecular Biology
Weiwei Wang, Zhang Guo, Dahua Xie, Zhiyong Lin, Ruisheng Lin
Summary: This study investigated the relationship between MMP-9 gene polymorphism and intracranial aneurysm, and the results showed a correlation between the two.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yihe Wang, Christine Y. Chuang, Clare L. Hawkins, Michael J. Davies
Summary: Matrix metalloproteinase-9 (MMP9) plays a crucial role in the degradation of extracellular matrix (ECM) proteins. This study demonstrates that MMP9 can be activated by both chloramines and oxidation. The activation of MMP9 and ECM degradation are interdependent processes that may contribute to the progression of diseases.
Article
Respiratory System
Wensi Zhu, Linxiao Han, Yuanyuan Wu, Lin Tong, Ludan He, Qin Wang, Yu Yan, Ting Pan, Jie Shen, Yuanlin Song, Yao Shen, Qiaoliang Zhu, Jian Zhou
Summary: The study found that the Krt15 gene has a protective effect on COPD through animal experiments and in vitro cell experiments. It can regulate the expression of matrix metalloproteinase-9 (MMP-9), inhibit epithelial-mesenchymal transition (EMT), and reduce the occurrence of chronic inflammation, airway remodeling, and emphysema. In addition, Krt15+ cells gradually increase in bronchial epithelial cells and transform into alveolar type II (AT2) cells, playing a role in protecting alveoli.
RESPIRATORY RESEARCH
(2023)
Article
Parasitology
Chuanchuan Liu, Haining Fan, Lu Guan, Ri-li Ge, Lan Ma
Summary: Crocin demonstrated parasiticidal activity against E. multilocularis both in vitro and in vivo. It showed lower toxicity to mammalian cells compared to metacestodes. Administration of crocin significantly reduced metacestode weight and caused structural disruption in the parasite.
PARASITES & VECTORS
(2021)
Review
Biochemistry & Molecular Biology
Zhenshengnan Li, Jia Wei, Bowen Chen, Yaoqi Wang, Shuai Yang, Kehui Wu, Xianying Meng
Summary: Matrix metalloproteinase-9 (MMP-9) is a zinc-dependent proteolytic metalloenzyme that degrades the extracellular matrix (ECM) and has been proven to be elevated in various pathological conditions, including thyroid carcinoma. Its expression level in malignant or metastatic thyroid tumor tissues is higher than in normal or benign tissues, and it correlates closely with clinical features such as lymph node metastasis, TNM stage, and tumor size.
Article
Surgery
Jing Shen, Jian-bo Song, Jun Fan, Zhe Zhang, Zheng-jia Yi, Shuo Bai, Xiao-lin Mu, Yao-bo Yang, Liang Xiao
Summary: This study simulated the process of neointima generation and regression after stent implantation, demonstrating the spatial distribution and dynamic changes of MMP-2, MMP-9, and collagen in ISR. The expression of MMP-2 and MMP-9 decreased and collagen content reached its maximum when ISR occurred, suggesting their potential contribution to ISR.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Ming-Ming Tsai, Jiun-Liang Chen, Tsong-Hai Lee, Hsiuming Liu, Velayuthaprabhu Shanmugam, Hsi-Lung Hsieh
Summary: Resveratrol can inhibit the expression of matrix metalloproteinase-9 (MMP-9) induced by IL-1 beta, reducing the disruption of tight junctions in brain microvascular endothelial cells caused by inflammation.
Article
Food Science & Technology
Frauke Assmus, Cecilia Galbete, Sven Knueppel, Matthias B. Schulze, Erik Beune, Karlijn Meeks, Mary Nicolaou, Stephen Amoah, Charles Agyemang, Kerstin Klipstein-Grobusch, Silver Bahendeka, Joachim Spranger, Frank P. Mockenhaupt, Liam Smeeth, Karien Stronks, Ina Danquah
Summary: The study characterized eating patterns among Ghanaian adults in Ghana and Europe, finding a rising gradient of snacking frequencies from rural to urban areas to Europe. Meal frequencies were similar across study sites, with meals rich in carbohydrates and total fats. Analysis suggests a nutrition transition among African populations, with increased snacking frequencies potentially impacting obesity and metabolic health.
FOOD & NUTRITION RESEARCH
(2021)
Article
Infectious Diseases
Lisa J. Kruger, Julian A. F. Klein, Frank Tobian, Mary Gaeddert, Federica Lainati, Sarah Klemm, Paul Schnitzler, Ralf Bartenschlager, Berati Cerikan, Christopher J. Neufeldt, Olga Nikolai, Andreas K. Lindner, Frank P. Mockenhaupt, Joachim Seybold, Terry C. Jones, Victor M. Corman, Nira R. Pollock, Britta Knorr, Andreas Welker, Margaretha de Vos, Jilian A. Sacks, Claudia M. Denkinger
Summary: The study confirmed that the microfluidic immunofluorescence LumiraDx (TM) assay has good sensitivity and specificity for SARS-CoV-2 detection. The assay also demonstrated favorable ease-of-use, making it a promising tool for pandemic control.
Article
Environmental Sciences
Sebastian Ruf, Franziska Hommes, Welmoed van Loon, Joachim Seybold, Tobias Kurth, Marcus A. Mall, Frank P. Mockenhaupt, Stefanie Theuring
Summary: The study investigated an outbreak in a Berlin kindergarten in November and December 2020 and found that viral spread within the facility mainly occurred through kindergarten staff, while children primarily transmitted infections within their families. To prevent outbreaks, strict adherence to hygiene rules, staff vaccinations against SARS-CoV-2, and immediate reaction to suspected cases by quarantining and frequent testing are reasonable measures.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Lisa J. Krueger, Amilcar Tanuri, Andreas K. Lindner, Mary Gaeddert, Lisa Koppel, Frank Tobian, Lukas E. Brummer, Julian A. F. Klein, Federica Lainati, Paul Schnitzler, Olga Nikolai, Frank P. Mockenhaupt, Joachim Seybold, Victor M. Corman, Terence C. Jones, Christian Drosten, Claudius Gottschalk, Stefan F. Weber, Stephan Weber, Orlando C. Ferreira, Diana Mariani, Erika Ramos dos Santos Nascimento, Terezinha M. Pereira Pinto Castineiras, Rafael Mello Galliez, Debora Souza Faffe, Isabela de Carvalho Leitao, Claudia dos Santos Rodrigues, Thiago Silva Frauches, Keity J. Chagas Vilela Nocchi, Natalia Martins Feitosa, Sabrina Santana Ribeiro, Nira R. Pollock, Britta Knorr, Andreas Welker, Margaretha de Vos, JilianA Sacks, Stefano Ongarello, Claudia M. Denkinger
Summary: This study evaluated the clinical performance and ease-of-use of seven SARS-CoV-2 antigen-detecting rapid diagnostic tests (Ag-RDTs). The results showed high sensitivity and specificity of the Ag-RDTs, especially in early-stage disease and individuals with high viral loads. The tests from Mologic, Bionote, and Standard Q demonstrated good usability.
Letter
Microbiology
Andreas K. Lindner, Lisa J. Krueger, Olga Nikolai, Julian A. F. Klein, Heike Roessig, Paul Schnitzler, Victor M. Corman, Terry C. Jones, Frank Tobian, Mary Gaeddert, Susen Burock, Jilian A. Sacks, Joachim Seybold, Frank P. Mockenhaupt, Claudia M. Denkinger
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, General & Internal
Rashid Mansoor, Robert J. Commons, Nicholas M. Douglas, Benjamin Abuaku, Jane Achan, Ishag Adam, George O. Adjei, Martin Adjuik, Bereket H. Alemayehu, Richard Allan, Elizabeth N. Allen, Anupkumar R. Anvikar, Emmanuel Arinaitwe, Elizabeth A. Ashley, Hazel Ashurst, Puji B. S. Asih, Nathan Bakyaita, Hubert Barennes, Karen Barnes, Leonardo Basco, Quique Bassat, Elisabeth Baudin, David J. Bell, Delia Bethell, Anders Bjorkman, Caroline Boulton, Teun Bousema, Philippe Brasseur, Hasifa Bukirwa, Rebekah Burrow, Verena Carrara, Michel Cot, Umberto D'Alessandro, Debashish Das, Sabyasachi Das, Timothy M. E. Davis, Meghna Desai, Abdoulaye A. Djimde, Arjen M. Dondorp, Grant Dorsey, Chris J. Drakeley, Stephan Duparc, Emmanuelle Espie, Jean-Francois Etard, Catherine Falade, Jean Francois Faucher, Scott Filler, Carole Fogg, Mark Fukuda, Oumar Gaye, Blaise Genton, Awab Ghulam Rahim, Julius Gilayeneh, Raquel Gonzalez, Rebecca F. Grais, Francesco Grandesso, Brian Greenwood, Anastasia Grivoyannis, Christoph Hatz, Eva Maria Hodel, Georgina S. Humphreys, Jimee Hwang, Deus Ishengoma, Elizabeth Juma, S. Patrick Kachur, Piet A. Kager, Erasmus Kamugisha, Moses R. Kamya, Corine Karema, Kassoum Kayentao, Adama Kazienga, Jean-Rene Kiechel, Poul-Erik Kofoed, Kwadwo Koram, Peter G. Kremsner, David G. Lalloo, Moses Laman, Sue J. Lee, Bertrand Lell, Amelia W. Maiga, Andreas Martensson, Mayfong Mayxay, Wilfred Mbacham, Rose McGready, Herve Menan, Didier Menard, Frank Mockenhaupt, Brioni R. Moore, Olaf Muller, Alain Nahum, Jean-Louis Ndiaye, Paul N. Newton, Billy E. Ngasala, Frederic Nikiema, Akindeh M. Nji, Harald Noedl, Francois Nosten, Bernhards R. Ogutu, Olusola Ojurongbe, Lyda Osorio, Jean-Bosco Ouedraogo, Seth Owusu-Agyei, Anil Pareek, Louis K. Penali, Patrice Piola, Mateusz Plucinski, Zul Premji, Michael Ramharter, Caitlin L. Richmond, Lars Rombo, Philip J. Rosenthal, Sam Salman, Albert Same-Ekobo, Carol Sibley, Sodiomon B. Sirima, Frank M. Smithuis, Fabrice A. Some, Sarah G. Staedke, Peter Starzengruber, Nathalie Strub-Wourgaft, Inge Sutanto, Todd D. Swarthout, Din Syafruddin, Ambrose O. Talisuna, Walter R. Taylor, Emmanuel A. Temu, Julie Thwing, Halidou Tinto, Emiliana Tjitra, Offianan A. Toure, T. Hien Tran, Johan Ursing, Innocent Valea, Giovanni Valentini, Michele van Vugt, Lorenz von Seidlein, Stephen A. Ward, Vincent Were, Nicholas J. White, Charles J. Woodrow, William Yavo, Adoke Yeka, Issaka Zongo, Julie A. Simpson, Philippe J. Guerin, Kasia Stepniewska, Ric N. Price, Cally Roper
Summary: In patients with uncomplicated P. falciparum malaria, the nadir hemoglobin occurs 2 days after starting treatment. Factors associated with moderately severe anemia on day 7 in Africa and Asia include severe anemia at baseline, young age, high parasitemia, and delayed parasite clearance. In Asia, artemisinin-based treatments are associated with a greater risk of anemia during recovery compared to non-artemisinin-based treatments.
Letter
Medicine, General & Internal
Samipa Pudasaini, Kira Louisa Boldt, Jennifer Hitzek, Linus Moeckel, Anna Slagman, Stefanie Theuring, Frank Mockenhaupt, Martin Moeckel
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2022)
Article
Infectious Diseases
Sophia Kindzierski, Welmoed van Loon, Stefanie Theuring, Franziska Hommes, Eberhard Thombansen, Malik Boettcher, Harald Matthes, Heike Roessig, David Weiger, Christof Wiesmann, Tobias Kurth, Valerie Kirchberger, Joachim Seybold, Frank P. Mockenhaupt, Maximilian Gertler
Summary: The prevalence of SARS-CoV-2 infection was assessed in teachers and preschool educators, with higher odds of infection found in preschool educators compared to teachers. The private environment was identified as a relevant source of infection for educational staff in 2020.
Article
Public, Environmental & Occupational Health
Andreas K. Lindner, Franziska Hommes, Olga Nikolai, Gabriela Equihua Martinez, Berna Guerer, Renate Krueger, Rasmus Leistner, Dennis Nurjadi, Frank P. Mockenhaupt, Philipp Zanger
Summary: PVL-positive S. aureus skin and soft tissue infections have a significant impact on patients' quality of life and mental health. However, physicians involved in pre-treatment often lack knowledge about the PVL toxin. Increased awareness for early diagnosis and treatment of this neglected disease is necessary.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Infectious Diseases
Carol A. Abidha, Yaw Ampem Amoako, Richard King Nyamekye, George Bedu-Addo, Florian Grziwotz, Frank P. Mockenhaupt, Arndt Telschow, Ina Danquah
Summary: This study aimed to investigate the susceptibility of adults with diabetes mellitus (DM) in malaria-endemic areas to Plasmodium infection. The results showed that fasting blood glucose (FBG) was causally affected by parasite density, and daily ambient temperature also affected parasite density. Longer observation periods and larger samples are needed to confirm these findings and determine the direction of causality.
Article
Environmental Sciences
Stefanie Theuring, Welmoed van Loon, Franziska Hommes, Norma Bethke, Marcus A. Mall, Tobias Kurth, Joachim Seybold, Frank P. Mockenhaupt
Summary: The COVID-19 pandemic has had a negative impact on the psychosocial wellbeing of students in Berlin, Germany. Anxiety symptoms and fear of infection increased, while social contacts and health-related quality of life decreased. Factors such as gender, age, school attendance, household income, and presence of adults with anxiety symptoms were associated with anxiety. Fear of infection and low HRQoL were also linked to anxiety.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Microbiology
Lisa J. Krueger, Andreas K. Lindner, Mary Gaeddert, Frank Tobian, Julian Klein, Salome Steinke, Federica Lainati, Paul Schnitzler, Olga Nikolai, Frank P. Mockenhaupt, Joachim Seybold, Victor M. Corman, Terry C. Jones, Nira R. Pollock, Britta Knorr, Andreas Welker, Stephan Weber, Nandini Sethurarnan, Jayanthi Swaminathan, Hilda Solomon, Ajay Padmanaban, Ma Thirunarayan, L. Prabakaran, Margaretha de Vos, Stefano Ongarello, Jilian A. Sacks, Camille Escadafal, Claudia M. Denkinger
Summary: Our manufacturer-independent prospective study assessed the clinical performance of participants with presumed SARS-CoV-2 infection at three study sites in two countries. We evaluated the accuracy overall and in predefined subgroups based on C-T values and symptom duration. The SureStatus diagnostic test showed high sensitivity, especially in the first few days after symptom onset and when C-T values were low. The system usability and ease-of-use assessment provided valuable insights for the widespread use of SureStatus in point-of-care settings. The high sensitivity demonstrated by the evaluated Ag-RDT during the early phase of infection supports its role in public health screening.
MICROBIOLOGY SPECTRUM
(2022)
Article
Endocrinology & Metabolism
Felix P. Chilunga, Pleun S. Schwerzel, Karlijn A. C. Meeks, Erik Beune, Silver Bahendeka, Frank Mockenhaupt, Kerstin Klipstein-Grobusch, Charles Agyemang
Summary: Psychosocial stress is associated with type 2 diabetes and glycaemic control among Ghanaians, especially in men. Negative life events are negatively correlated with type 2 diabetes, while perceived discrimination is positively correlated with type 2 diabetes.
Article
Pediatrics
Stefanie Theuring, Mascha Kern, Franziska Hommes, Marcus A. A. Mall, Joachim Seybold, Frank P. P. Mockenhaupt, Toivo Glatz, Tobias Kurth
Summary: During the COVID-19 pandemic, children and adolescents worldwide have been disproportionately affected in their psychological health and wellbeing. A cohort study in Germany found that anxiety symptoms among school children decreased from June to August 2021, but increased again in September 2021. Factors such as gender, school type, household education and income level, and COVID-19 vaccination were significantly associated with reporting anxiety symptoms.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Article
Immunology
Welmoed van Loon, Rafael Oliveira, Clara Bergmann, Felix Habarugira, Jules Ndoli, Augustin Sendegeya, Claude Bayingana, Frank P. Mockenhaupt
Summary: The study documented artemisinin resistance in Plasmodium falciparum patient isolates from Rwanda carrying K13 R561H, A675V, and C469F mutations, indicating the presence of artemisinin resistance in the region.
EMERGING INFECTIOUS DISEASES
(2022)
