Article
Medicine, Research & Experimental
Bogdan Veliceasa, Alexandru Filip, Mihaela Pertea, Dragos Popescu, Claudiu Carp, Ovidiu Alexa
Summary: This retrospective study assessed the outcomes of a modified Stoppa approach using an anatomically precontoured plate for the treatment of acetabular fractures. Most patients had good reduction quality, acceptable intraoperative blood loss and fluoroscopy dose, low postoperative complications, effective fixation, and favorable hip joint function recovery outcomes.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Orthopedics
Ruyi Zou, Min Wu, Jianzhong Guan, Yuzhou Xiao, Xiaotian Chen
Summary: A retrospective analysis was conducted on 60 patients with acetabular fractures to compare the clinical efficacy of the pararectus and ilioinguinal approaches. Results showed no significant difference in intraoperative blood loss or hip function scores at the last follow-up, suggesting both approaches can achieve satisfactory surgical results with similar outcomes in terms of surgical effects and complications.
ORTHOPAEDIC SURGERY
(2021)
Article
Orthopedics
Xiaofeng Chen, Haiyang Wu, Kunming Cheng, Ximing Liu, Xianhua Cai
Summary: This study proposed the concept of inclined angles of the acetabular quadrilateral plate and investigated their normal range in adults. A modified Matta criteria that combined the classic Matta criteria and the evaluation criteria of the inclined angles was proposed. The results showed that the inclined angles could be used to assess the quality of fracture reduction and provide additional information for evaluating the rotational displacement of fracture blocks in the quadrilateral plate.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Critical Care Medicine
M. Scrivano, A. Vadal, G. Fedeli, R. Di Niccolo, D. Topa, S. Porcino, F. Pallotta, A. De Carli
Summary: This study compares the outcomes and complications of Ilioinguinal versus modified Stoppa approach in Open Reduction and Internal Fixation (ORIF) of anterior column acetabulum fractures. The results show that the modified Stoppa approach has a shorter operative time, less intra-operative blood loss, and fewer complications. The ilioinguinal approach achieves better anatomic reduction. However, there were no significant differences in terms of vascular lesions, clinical and functional outcomes between the two groups.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Orthopedics
Gianluca Ciolli, Domenico De Mauro, Giuseppe Rovere, Amarildo Smakaj, Silvia Marino, Lorenzo Are, Omar El Ezzo, Francesco Liuzza
Summary: The study evaluated the effectiveness of QLS plates in combination with the AIP approach for the treatment of acetabular fractures with anterior involvement. Results showed a significant relationship between radiological outcomes and clinical outcomes.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Medicine, General & Internal
Beom-Soo Kim, Ki-Cheor Bae, Chul-Hyun Cho, Kyung-Jae Lee, In Gyu Lee, Min-Gyu Lee, Byung-Woo Min
Summary: This study investigated the reduction effect of direct fixation of quadrilateral plates in acetabular fractures and compared it with indirect fixation. The results showed that patients in the direct fixation group had a lower incidence of post-traumatic osteoarthritis and achieved better anatomical reduction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Domenico De Mauro, Giuseppe Rovere, Lorenzo Are, Amarildo Smakaj, Alessandro Aprato, Umberto Mezzadri, Federico Bove, Alessandro Casiraghi, Silvia Marino, Gianluca Ciolli, Simone Cerciello, Giuseppe Maccagnano, Giovanni Noia, Alessandro Masse, Giulio Maccauro, Francesco Liuzza
Summary: This study aims to investigate the clinical and radiological outcomes of spring plates in the treatment of comminuted posterior wall acetabular fractures. The results suggest that spring plates can be considered a viable fixation method for posterior wall acetabular fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Emergency Medicine
Johannes Dominik Bastian, David Riccardo Naf, Jennifer Larissa Cullmann, Marius Johann Keel, Peter V. Giannoudis
Summary: This study found that the acetabular configuration affects the safety of infra-acetabulum screw insertion, with the distance between the screw and the femoral head decreasing as the depth of the acetabulum increases. Female patients, in particular, need to be aware of the risk of screw mispositioning.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2021)
Article
Orthopedics
ZhiDong Wang, ZhenHeng Wang, GuangDong Chen, MaoFeng Gao, RuoFu Zhu, HuiLin Yang
Summary: This study aimed to explore the clinical effects of applying an anterior pelvic wall locking plate (APWLP) through the lateral-rectus approach for treating acetabular fractures involving the quadrilateral surface. A retrospective analysis of 35 patients who were treated with an APWLP showed that the procedure achieved good to excellent clinical and radiological outcomes and may be a new treatment option for these fractures.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Orthopedics
Kai Ye, Jianfei Tang, Longxiang Shen, Zhiquan An
Summary: In ABC fractures, there was only one QP fragment in nearly 90% of all cases. The QP fractures were mainly present in the QP's peripheral area. More than 80% of the fracture patterns on the cephalic side of the QP were simple.
SKELETAL RADIOLOGY
(2022)
Article
Geriatrics & Gerontology
Antonello Panella, Giuseppe Solarino, Giovanni Vicenti, Davide Bizzoca, Marco Baglioni, Francesco Fortunato, Francesco Maruccia, Angela Notarnicola, Andrea Piazzolla, Raffaele Pascarella, Alberto Belluati, Biagio Moretti
Summary: In elderly patients with osteoporotic QP fractures, there were no significant differences in functional recovery at 24 months follow-up between those who underwent anatomical reconstruction (displacement 0-1 mm) compared to those who received a good QP fracture reconstruction (displacement <= 3 mm).
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Critical Care Medicine
Edgardo Ramos, Armando Torres, Hector Torres, Ingmar Buffo, Fernando Garcia, Eduardo Callejas, Moises Micha, Valeria Alvarez
Summary: This study describes a new paramedial approach and reverse fixation plate osteosynthesis technique for acetabular fractures. Through cadaveric specimens and statistical analysis, it confirms the safety and stability of this method, showing potential for improved surgical outcomes.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Orthopedics
Yizhou Wan, Sheng Yao, Yan Ma, Lian Zeng, Yulong Wang, Yanzhen Qu, Guixiong Huang, Xiaodong Guo, Kaifang Chen
Summary: This study evaluated the clinical effectiveness of a novel infra-pectineal quadrilateral surface buttress plates for the treatment of geriatric acetabular fractures. The results showed that this method provided stable and effective fixation to the quadrilateral surface involved acetabular fractures in elderly patients, and satisfactory clinical outcomes with few complications were observed.
ORTHOPAEDIC SURGERY
(2022)
Review
Medicine, General & Internal
Xue-Feng Zhou, Si-Chao Gu, Wan-Bo Zhu, Jia-Zhao Yang, Lei Xu, Shi-Yuan Fang
Summary: This paper reviewed the anatomical features, definition and classification, operative approach selection, implant internal fixation methods and efficacy of the quadrilateral plate. Having a thorough understanding of the quadrilateral plate can optimize patient prognosis.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Orthopedics
Umesh Kumar Meena, Arun Kumar Sharma, Prateek Behera, Ravinder Kumar Lamoria, Ramesh Chand Meena, Pramod Kumar Chahar
Summary: This retrospective study compared the outcomes of patients with QLP fractures treated with either a buttress plate through an ilioinguinal approach or an infra-pectineal plate using the modified Stoppa approach. The results showed that the infra-pectineal plate approach had shorter surgery duration and less intra-operative blood loss, as well as better clinical and radiological outcomes at least one year after the surgery. Therefore, it can be considered the preferred treatment for most acetabular fractures with QLP involvement.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2022)
Article
Surgery
Anthony Howard, Robert M. West, Gareth Iball, Michalis Panteli, Mantaran Singh Baskshi, Hemant Pandit, Peter V. Giannoudis
Summary: The study found that a proportion of younger polytrauma patients were exposed to high levels of radiation, thereby increasing the risk of developing cancer. The results suggest that Injury Severity Score, age, injury pattern, and length of hospital stay are predictive of both radiation exposure and cancer risk.
Editorial Material
Surgery
Anthony Howard, Harry Hodgson, James Vun, Michalis Panteli, Jeya Palan, Hemant Pandit, Peter V. Giannoudis
Article
Medicine, General & Internal
Theodoros H. Tosounidis, Colin Holton, Vasileios P. Giannoudis, Nikolaos K. Kanakaris, Robert M. West, Peter V. Giannoudis
Summary: Study investigated correlation between elevated CRP and WBC levels in nonunion patients, finding elevated CRP levels increased infection risk. WBC count unreliable for predicting infection. All cases achieved solid union post-revision surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Michalis Panteli, Marilena P. Giannoudi, Christopher J. Lodge, Robert M. West, Ippokratis Pountos, Peter V. Giannoudis
Summary: This study aimed to define the incidence of subtrochanteric femoral fractures and investigate associations with mortality and medical complications following intramedullary nail treatment. Risk factors for mortality included low albumin, dementia, pneumonia, and high Charlson comorbidity score. Factors such as ICU/HDU stay, asthma/COPD, and prolonged hospital stay were associated with higher incidence of hospital acquired pneumonia. Early identification of these factors could aid in prognostication and prevention of poor outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Dionysios J. Papachristou, Stavros Georgopoulos, Peter Giannoudis, Elias Panagiotopoulos
Summary: Fracture-healing is a complex process that may fail, leading to delayed unions or non-unions. Research and clinical studies are focusing on unraveling the mechanisms regulating fracture-healing, aiming to develop more effective therapeutic strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Michalis Panteli, James S. H. Vun, Robert M. West, Anthony Howard, Ippokratis Pountos, Peter V. Giannoudis
Summary: This study aimed to investigate the incidence, risk factors and pathogenic microorganisms causing infection in patients with subtrochanteric femoral fractures managed with an intramedullary nail. Deep infection was associated with non-union, open fracture, massive transfusion, post-operative transfusion and prolonged length of stay. Staphylococcus aureus and coliforms were the most common microorganisms identified in superficial and deep infections, respectively, with polymicrobial infection present in a significant proportion of cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Emergency Medicine
Michalis Panteli, James Shen Hwa Vun, Robert Michael West, Anthony John Howard, Ippokratis Pountos, Peter Vasilios Giannoudis
Summary: Open reduction of subtrochanteric femoral fractures is not associated with an increased risk of deep infection and non-union, but is related to an increased risk of superficial infection, prolonged surgical time, and transfusion. The use of cerclage wires is associated with a reduced risk of non-union and a slight increase in complications.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Review
Cell Biology
Michalis Panteli, James S. H. Vun, Ippokratis Pountos, Anthony J. Howard, Elena Jones, Peter V. Giannoudis
Summary: Fracture non-union is a common complication with a high incidence rate, but the understanding of its biological, molecular, and genetic profiles is still limited. This review investigates the characteristics of non-union tissue and related tissues, aiming to improve early identification and targeted treatment of high-risk patients, and to enhance the understanding of the pathophysiology of fracture non-union.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Michalis Panteli, James S. H. Vun, Robert M. West, Anthony J. Howard, Ippokratis Pountos, Peter V. Giannoudis
Summary: This study developed and validated a predictive model for non-union following subtrochanteric fractures of the femur. By identifying risk factors and creating a risk score, high-risk patients can be identified early post-operatively. The scoring system demonstrated good discriminatory capability, calibration, and internal validity, providing valuable information for surgeons to intervene and modify surgery-related factors to reduce the risk of non-union.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Angelos Kaspiris, Argyris C. Hadjimichael, Elias S. Vasiliadis, Dionysios J. Papachristou, Peter V. Giannoudis, Elias C. Panagiotopoulos
Summary: This study investigated the clinical implantation of growth factors for intraoperative enhancement of osteogenesis in the treatment of long bone fractures and non-unions. The results showed that the application of BMP-2 and -7, PRP, and MSCs significantly increased the effectiveness of fracture treatment and postoperative functional scores.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Michalis Panteli, James S. H. Vun, Robert M. West, Anthony Howard, Ippokratis Pountos, Peter V. Giannoudis
Summary: Intramedullary nails are commonly used to treat subtrochanteric femoral fractures, but the risk factors for re-operation and the outcomes of different nailing systems are still unclear. This study found that age, choice of nail, reduction angle, and other factors were associated with an increased risk of re-operation. The Affixus nail demonstrated better survival up to 5 years post-implantation compared to the Gamma nail. However, the addition of a proximal anti-rotation screw did not provide any benefit.
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2022)
Article
Emergency Medicine
Michalis Panteli, Panayiotis Souroullas, Sushmith R. Gowda, James S. H. Vun, Anthony J. Howard, Nikolaos K. Kanakaris, Peter Giannoudis
Summary: This study aims to investigate the outcomes of elderly patients (over 60 years of age) with acetabular fractures treated with open reduction and internal fixation (ORIF), focusing on the risk for need of further surgery and associated factors. The results suggest that ORIF is a safe and reliable option for elderly patients with acetabular fractures, although a relatively high incidence of severe post-operative arthritis was observed.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Medicine, General & Internal
James Tebby, Vasileios P. Giannoudis, Sophia M. Wakefield, Fiona Lecky, Omar Bouamra, Peter V. Giannoudis
Summary: Managing patients with multiple injuries, especially those with comorbidities such as diabetes mellitus, remains challenging and increases mortality. This study investigates the impact of major trauma centres in the UK on the outcomes of polytrauma patients with diabetes. The findings show that while overall mortality has decreased, patients with diabetes still had higher mortality compared to other groups, highlighting diabetes as an independent risk factor for mortality in polytrauma patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
George Kleftouris, Theodoros H. H. Tosounidis, Michalis Panteli, Martin Gathen, Peter V. V. Giannoudis
Summary: A prospective, feasibility, randomised study was conducted to compare intramedullary and extramedullary fixation for unstable pertrochanteric fractures, and to assess the feasibility of including patients with dementia. The study found that there was no difference in randomisation rate between patients with and without cognitive impairment, but a higher proportion of patients without cognitive impairment attended the 12-week follow-up. The overall recruitment rate was 0.9 patients per week. Patients treated with the Endovis nail had lower levels of pain at two weeks and better radiographic outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Jehan J. El-Jawhari, Payal Ganguly, Elena Jones, Peter Giannoudis
Summary: This review discusses the application of bone marrow-derived mesenchymal stromal cells in treating osteonecrosis, including donor-related factors, the impact of aging on donor-related variability, and factors influencing the quantity and function of these cells.
BIOENGINEERING-BASEL
(2021)