期刊
ANTIVIRAL RESEARCH
卷 98, 期 3, 页码 373-379出版社
ELSEVIER
DOI: 10.1016/j.antiviral.2013.04.009
关键词
Chronic hepatitis C; Treatment; Statin; Interferon alfa; Ribavirin
资金
- National Natural Science Foundation of China [81071371]
The treatment of interferon alfa (IFN-alpha) and ribavirin for chronic hepatitis C virus (HCV) infection achieves limited sustained virological response (SVR). We conducted a systematic review and meta-analysis to explore the efficacy of adding statins to IFN-alpha and ribavirin therapy for chronic hepatitis C. Studies with data pertinent to the effect of statins on chronic hepatitis C were reviewed, and randomized controlled trials (RCTs) evaluating the efficacy of the addition of statins to IFN-alpha and ribavirin were included in meta-analysis. The primary outcome measure was SVR. Secondary outcome measures were rapid virological response (RVR) and early virological response (EVR). The literature was systematically searched through October 2012. After screening of the 1724 non-duplicated entries, 54 potentially relevant studies were fully reviewed. Of those, 18 studies were relevant and 5 RCTs met the inclusion criteria for meta-analysis. In comparison with IFN-alpha and ribavirin therapy, the addition of statins significantly increased SVR (OR = 2.02, 95% CI: 1.38-2.94), RVR (OR = 3.51, 95% CI: 1.08-11.42) and EVR (OR = 1.89, 95% CI: 1.20-2.98). The SVR increase remained significant for HCV genotype 1 (OR = 2.11, 95% CI: 1.40-3.18). There were no significant increases in adverse events and withdrawals with the addition of statins. In conclusion, the addition of statins to IFN-a and ribavirin improves SVR, RVR, and EVR without additional adverse events and thus may be considered as adjuvant to IFN-alpha and ribavirin for chronic hepatitis C. Statins might also be used for HCV genotypes other than genotype 1, or in patients in whom the use of protease inhibitors is contraindicated or not indicated. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据