Article
Pharmacology & Pharmacy
Sook Kwan Brown, Yeu-Yang Tseng, Ammar Aziz, Mariana Baz, Ian G. Barr
Summary: This study tested 3425 influenza B viruses collected from the Asia-Pacific region against four registered neuraminidase inhibitors (NAIs). It identified 45 influenza B viruses with reduced susceptibility to one or more NAIs, including some with newly identified neuraminidase mutations. The study highlights the potential impact of these mutations on the clinical effectiveness of NAIs in treating influenza B infections in humans.
ANTIVIRAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ha T. Nguyen, Anton Chesnokov, Juan De La Cruz, Philippe Noriel Q. Pascua, Vasiliy P. Mishin, Yunho Jang, Joyce Jones, Han Di, Andrei A. Ivashchenko, Mary Lea Killian, Mia K. Torchetti, Kristina Lantz, David E. Wentworth, Charles T. Davis, Alexandre V. Ivachtchenko, Larisa V. Gubareva
Summary: The susceptibility of highly pathogenic avian influenza (HPAI) A(H5N1) viruses to influenza antivirals was evaluated. Among 1,015 sequences collected in the United States in 2022, about 0.8% showed molecular markers of drug resistance. In addition, mutations that may reduce susceptibility to antiviral inhibitors were found in 31 viruses. Close monitoring of drug susceptibility is needed to assess public health risks and inform antiviral stockpiling decisions.
ANTIVIRAL RESEARCH
(2023)
Article
Immunology
Konstantin Andreev, Jeremy C. Jones, Patrick Seiler, Ahmed Kandeil, Jasmine C. M. Turner, Subrata Barman, Adam M. Rubrum, Richard J. Webby, Elena A. Govorkova
Summary: The antiviral susceptibility of currently circulating highly pathogenic avian influenza A(H5N1) viruses was assessed using genotypic and phenotypic approaches. The majority of the viruses retain susceptibility to antiviral drugs, but novel mutations have been identified that reduce the inhibitory effects of certain drugs.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Ping Li, Ruikun Du, Zinuo Chen, Yanyan Wang, Peng Zhan, Xinyong Liu, Dongwei Kang, Zhaoyu Chen, Xiujuan Zhao, Lin Wang, Lijun Rong, Qinghua Cui
Summary: Punicalagin from plants shows strong anti-influenza activity with a low micromolar IC(50)value. It primarily targets NA-mediated viral release, inhibits replication of different strains of influenza A and B viruses, including oseltamivir-resistant virus (NA/H274Y), and is a potential novel antiviral against influenza viruses.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Chemistry, Medicinal
Avishak Sarker, Zichen Gu, Lu Mao, Yongzhuang Ge, Duoduo Hou, Jieyu Fang, Zhanyong Wei, Zhenya Wang
Summary: Influenza is a century-old disease that poses challenges to humans due to its mutating nature, seasonal epidemics, and occasional pandemics. The limited effectiveness of strain-specific vaccines and the growing drug resistance to anti-influenza drugs call for the development of novel drugs with broad reactivity, higher bioavailability, easier administration, and fewer side effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Yu-Jen Chang, Cheng-Yun Yeh, Ju-Chien Cheng, Yu-Qi Huang, Kai-Cheng Hsu, Yu-Feng Lin, Chih-Hao Lu
Summary: Eradicating influenza A virus (IAV) is challenging due to its genetic variability. Hemagglutinin (HA) is a promising target for anti-influenza drugs, but its complex structure has hindered structural characterization. Computational analysis identified potential HA inhibitors in the National Cancer Institute database.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Medicinal
Kuanglei Wang, Huicong Zhang, Yongshou Tian
Summary: This review covers influenza drugs, mutation types of neuraminidase, molecular mechanisms of drug resistance, strategies to enhance drug susceptibility, and alternative therapies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Garcia-Machorro Jazmin, Mirzaeicheshmeh Elaheh, Fragoso-Vazquez Manuel Jonathan, Bello Martiniano, Mendez-Luna David, Leon-Cardona Alam, Correa-Basurto Jose
Summary: Antiviral resistance is a global concern, particularly in the case of influenza A H1N1 which has developed resistance to oseltamivir and zanamivir. A new compound derived from oseltamivir was designed using computational methods and tested against influenza A H1N1. The compound showed significant affinity for both the neuraminidase (NA) and hemagglutinin (HA) proteins of the virus, as confirmed by in silico and in vitro assays, and it also demonstrated effectiveness in reducing viral susceptibility without any cytotoxic effects. The compound's high affinity for the viral NA enzyme, supported by molecular dynamics simulations, suggests its potential as an antiviral against influenza A H1N1.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Pharmacology & Pharmacy
Mira C. Patel, Daniel Flanigan, Chenchen Feng, Anton Chesnokov, Ha T. Nguyen, Anwar Abd Elal, John Steel, Rebecca J. Kondor, David E. Wentworth, Larisa V. Gubareva, Vasiliy P. Mishin
Summary: IRINA is a novel influenza virus inhibition assay that measures the enzymatic activity of nascent neuraminidase expressed on virus-infected cells, replacing the traditional immunostaining and imaging procedures. This method can effectively assess the activity of antiviral drugs and antigens, with high throughput capacity and reproducibility.
ANTIVIRAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
C. Joaquin Caceres, Brittany Seibert, Flavio Cargnin Faccin, Stivalis Cardenas-Garcia, Daniela S. Rajao, Daniel R. Perez
Summary: This article summarizes the current knowledge of approved influenza antivirals and antiviral strategies under evaluation in clinical trials, highlighting the importance of further improvement and development of novel anti-influenza drugs.
Article
Infectious Diseases
Naoki Tani, Naoki Kawai, Yong Chong, Takuma Bando, Norio Iwaki, Seizaburo Kashiwagi, Hideyuki Ikematsu
Summary: This study investigated the susceptibility of epidemic influenza viruses to neuraminidase inhibitors and the emergence of resistant viruses after treatment. The results suggest the continued effectiveness of these inhibitors for epidemic influenza in Japan. Treatment-emergent resistant viruses were detected after oseltamivir treatment.
JOURNAL OF INFECTION
(2022)
Article
Public, Environmental & Occupational Health
Thiago das Chagas Sousa, Jessica Santa Cruz Carvalho Martins, Milene Dias Miranda, Cristiana Couto Garcia, Paola Cristina Resende, Cliomar A. A. Santos, Maria do Carmo Debur, Rodrigo Ribeiro Rodrigues, Andrea Cony Cavalcanti, Tatiana Schaffer Gregianini, Felipe Campos de Melo Iani, Felicidade Mota Pereira, Sandra Bianchini Fernandes, Jessylene de Almeida Ferreira, Katia Correa de Oliveira Santos, Fernando Motta, David Brown, Walquiria Aparecida Ferreira de Almeida, Marilda Mendonca Siqueira, Aline da Rocha Matos
Summary: This study evaluated the antiviral resistance of Brazilian influenza A virus strains and found a low prevalence of resistance markers, indicating that antiviral drugs are still effective. However, there is a need for strengthened surveillance of influenza resistance.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Chemistry, Medicinal
Hui-Xian Wang, Mao-Sen Zeng, Yi Ye, Jin-Yuan Liu, Pei-Ping Xu
Summary: Puerarin, a major isoflavone compound from Pueraria lobata root, exhibits various properties including anti-inflammatory, antioxidant, and antiviral effects. It shows inhibitory activity against H1N1 influenza virus by blocking viral NP transport and newly formed virus particle release. In vivo studies demonstrate its potential as a treatment for influenza virus infection, with effective antiviral activity and reduced inflammation in the lungs.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Jeremy C. Jones, Hui-Ling Yen, Peter Adams, Kimberly Armstrong, Elena A. Govorkova
Summary: Effective antivirals play a crucial role in the early phase of an influenza pandemic, before vaccines are available. Currently, two classes of antiviral drugs are approved for influenza treatment, but resistance has been observed. Therefore, it is important to develop novel antiviral options that target both the virus and the host. This review explores the drawbacks of current antivirals and ongoing research on new agents or combination therapies to address these limitations.
ANTIVIRAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Lorenzo Gatti, Mischa H. Koenen, Jitao David Zhang, Maria Anisimova, Lilly M. Verhagen, Martin Schutten, Ab Osterhaus, Erhard van der Vries
Summary: Several human pathogens exhibit distinct seasonal patterns and circulate in pairs. This study found that the number of influenza A virus infections alternates between the A/H1N1 and A/H3N2 subtypes, indicating competition between different strains. The results also suggest that cross-reactive host immunity plays a role in determining the influenza A virus strain each season.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Chenyi Xie, Eric H. Y. Lau, Tomoyo Yoshida, Han Yu, Xin Wang, Huitao Wu, Jianjian Wei, Ben Cowling, Malik Peiris, Yuguo Li, Hui-Ling Yen
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Pharmacology & Pharmacy
Emi Takashita, Rod S. Daniels, Seiichiro Fujisaki, Vicki Gregory, Larisa Gubareva, Weiijuan Huang, Aeron C. Hurt, Angie Lackenby, Ha T. Nguyen, Dmitriy Pereyaslov, Merryn Roe, Magdi Samaan, Kanta Subbarao, Herman Tse, Dayan Wang, Hui-Ling Yen, Wenqing Zhang, Adam Meijer
ANTIVIRAL RESEARCH
(2020)
Letter
Medicine, General & Internal
Lirong Zou, Feng Ruan, Mingxing Huang, Lijun Liang, Huitao Huang, Zhongsi Hong, Jianxiang Yu, Min Kang, Yingchao Song, Jinyu Xia, Qianfang Guo, Tie Song, Jianfeng He, Hui-Ling Yen, Malik Peiris, Jie Wu
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Review
Construction & Building Technology
Nan Zhang, Wenzhao Chen, Pak-To Chan, Hui-Ling Yen, Julian Wei-Tze Tang, Yuguo Li
Article
Engineering, Chemical
Han Yu, Hui-Ling Yen, Yuguo Li
JOURNAL OF AEROSOL SCIENCE
(2020)
Article
Multidisciplinary Sciences
Sin Fun Sia, Li-Meng Yan, Alex W. H. Chin, Kevin Fung, Ka-Tim Choy, Alvina Y. L. Wong, Prathanporn Kaewpreedee, Ranawaka A. P. M. Perera, Leo L. M. Poon, John M. Nicholls, Malik Peiris, Hui-Ling Yen
Correction
Biochemistry & Molecular Biology
Nancy H. L. Leung, Daniel K. W. Chu, Eunice Y. C. Shiu, Kwok-Hung Chan, James J. McDevitt, Benien J. P. Hau, Hui-Ling Yen, Yuguo Li, Dennis K. M. Ip, J. S. Malik Peiris, Wing-Hong Seto, Gabriel M. Leung, Donald K. Milton, Benjamin J. Cowling
Article
Biochemistry & Molecular Biology
Nancy H. L. Leung, Daniel K. W. Chu, Eunice Y. C. Shiu, Kwok-Hung Chan, James J. McDevitt, Benien J. P. Hau, Hui-Ling Yen, Yuguo Li, Dennis K. M. Ip, J. S. Malik Peiris, Wing-Hong Seto, Gabriel M. Leung, Donald K. Milton, Benjamin J. Cowling
Article
Pharmacology & Pharmacy
Ka-Tim Choy, Alvina Yin-Lam Wong, Prathanporn Kaewpreedee, Sin Fun Sia, Dongdong Chen, Kenrie Pui Yan Hui, Daniel Ka Wing Chu, Michael Chi Wai Chan, Peter Pak-Hang Cheung, Xuhui Huang, Malik Peiris, Hui-Ling Yen
ANTIVIRAL RESEARCH
(2020)
Article
Construction & Building Technology
Wenzhao Chen, Nan Zhang, Jianjian Wei, Hui-Ling Yen, Yuguo Li
BUILDING AND ENVIRONMENT
(2020)
Article
Environmental Sciences
Zhen Ding, Hua Qian, Bin Xu, Ying Huang, Te Miao, Hui-Ling Yen, Shenglan Xiao, Lunbiao Cui, Xiaosong Wu, Wei Shao, Yan Song, Li Sha, Lian Zhou, Yan Xu, Baoli Zhu, Yuguo Li
Summary: Respiratory and fecal aerosols have confirmed and suspected roles in transmitting SARS-CoV-2, with fecal-derived aerosols in patients' toilets containing most of the detected virus. Surface and hand hygiene are crucial for intervention to prevent transmission.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Virology
Jian Zheng, Liyan Wen, Hui-Ling Yen, Ming Liu, Yinping Liu, Ooiean Teng, Wing-Fung Wu, Ke Ni, Kowk-Tai Lam, Chunyu Huang, Jiashuang Yang, Yu-Lung Lau, Stanley Perlman, Malik Peiris, Wenwei Tu
Summary: In this study, a novel HA-specific NKp46(+) NKG2A(+) NK cell subset induced by influenza A virus infection is demonstrated. These memory NK cells exhibit decreased cytotoxicity and increased IFN-gamma response when encountering the same influenza virus antigen again. Moreover, they modulate host recall responses and CD8 T cell distribution, bridging the innate immune and adaptive immune responses during influenza virus infection.
JOURNAL OF VIROLOGY
(2021)
Article
Chemistry, Physical
Lu Zhang, Dong Zhang, Xiaowei Wang, Congmin Yuan, Yongfang Li, Xilin Jia, Xin Gao, Hui-Ling Yen, Peter Pak-Hang Cheung, Xuhui Huang
Summary: Remdesivir effectively inhibits SARS-CoV-2 viral RNA replication by interfering with nucleotide addition and proofreading mechanisms, reducing the likelihood of viral replication. The molecular dynamics simulations provide insights into the inhibitory mechanisms of Remdesivir, guiding potential rational designs for new COVID-19 treatments targeting viral replication.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Microbiology
Ranawaka A. P. M. Perera, Ronald Ko, Owen T. Y. Tsang, David S. C. Hui, Mike Y. M. Kwan, Christopher J. Brackman, Esther M. W. To, Hui-Ling Yen, Kathy Leung, Samuel M. S. Cheng, Kin Ho Chan, Karl C. K. Chan, Ka-Chi Li, Linda Saif, Vanessa R. Barrs, Joseph T. Wu, Thomas H. C. Sit, Leo L. M. Poon, Malik Peiris
Summary: The surrogate virus neutralization test (sVNT) showed high sensitivity and specificity compared to the plaque reduction neutralization test (PRNT90) in human, canine, cat, and hamster sera. There was no cross-reactivity to other coronaviruses in both SARS-CoV-2 sVNT and PRNT90, except for cross-reactivity to SARS-CoV-1 in sVNT.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Engineering, Environmental
Baihuan Feng, Kaijin Xu, Silan Gu, Shufa Zheng, Qianda Zou, Yan Xu, Ling Yu, Fangyuan Lou, Fei Yu, Tao Jin, Yuguo Li, Jifang Sheng, Hui-Ling Yen, Zifeng Zhong, Jianjian Wei, Yu Chen
Summary: The study found that SARS-CoV-2 can be transmitted through various routes in healthcare settings, but the viral load of COVID-19 patients decreases in the later days after symptom onset, resulting in a low detection frequency of viral RNA in breath and environmental specimens.
JOURNAL OF HAZARDOUS MATERIALS
(2021)