Article
Multidisciplinary Sciences
Li Wei Ang, Oon Tek Ng, Irving Charles Boudville, Yee Sin Leo, Chen Seong Wong
Summary: Metabolic syndrome (MetS) is common in people living with HIV (PLHIV) in Singapore, with a prevalence of 23.6%. The most common metabolic abnormality is HDL hypocholesterolemia and hypertriglyceridemia. Regular monitoring, surveillance of drug effects, and behavioral interventions are needed for optimal management and prevention of metabolic disorders in PLHIV due to the long-term use of cART.
Article
Infectious Diseases
Carmen Maria Gonzalez-Domenech, Isaac J. Plaza-Andrades, Lourdes Garrido-Sanchez, Maria Isabel Queipo-Ortuno
Summary: This study aimed to assess the impact of lipodystrophy associated with metabolic syndrome on oxidative stress and inflammation in HIV-infected patients. The study found that patients with lipodystrophy and metabolic syndrome had worse biochemical and metabolic profiles, as well as higher levels of oxidative stress and inflammation. Treatment regimens containing protease inhibitors further exacerbated these conditions.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2022)
Review
Pharmacology & Pharmacy
Violet Dismas Kajogoo, Mary Gorret Atim, Demeke Amare, Melka Geleta, Yilkal Muchie, Hanna Amanuel Tesfahunei, Willyhelmina Olomi, Joan Acam, Tsegahun Manyazewal
Summary: This study analyzed the impact of Protease Inhibitors (PIs) on insulin sensitivity and the onset of diabetes mellitus (DM) in HIV patients. The results showed that among PIs, atazanavir, fosamprenavir, and darunavir did not demonstrate significant changes in insulin sensitivity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Alba Llibre, Martin Dedicoat, Julie G. Burel, Caroline Demangel, Matthew K. O'Shea, Claudio Mauro
Summary: This review provides a comprehensive understanding of the immune-metabolic adaptations of macrophages to mycobacterial infections. It discusses the changes in glycolysis, oxidative metabolism, and fatty acid utilization in response to mycobacteria, as well as the impact of critical tuberculosis co-morbidities on host metabolic responses. The review also explores how immune-metabolic knowledge can be utilized for the development of new diagnostic and therapeutic strategies for mycobacterial diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Veronna Marie, Michelle Gordon
Summary: This study used molecular dynamics simulations to explore the co-evolutionary molecular mechanisms of resistance in HIV-1 PR and Gag, showing that resistance mutations in PR can alter drug binding and exacerbate binding when mutant PRs are bound to mutated Gag cleavage sites. The research also demonstrated that co-selection of mutations in both enzyme and substrate can lead to complex mechanisms of resistance, affecting the active site and flap flexibility in PR.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Infectious Diseases
Frank Mulindwa, Barbara Castelnuovo, Bruce Kirenga, Dennis Kalibbala, Priscilla Haguma, Martin Muddu, Fred C. Semitala
Summary: Despite the low utilization of double dose LPV/r in HIV patients on rifampicin-based TB treatment in Uganda's public HIV clinics, it does not seem to impact patient survival and viral suppression.
BMC INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Sunday N. Okafor, Pavimol Angsantikul, Hashim Ahmed
Summary: This research utilized computational tools to screen a large compound library and identified potential HIV-1 protease inhibitors. Two optimized molecules showed promising activity and should be further investigated in vitro and in clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Kirtika Madan, Sarvesh Paliwal, Swapnil Sharma, Seema Kesar, Neha Chauhan, Mansi Madan
Summary: Metabolic syndrome, characterized by a cluster of diseases such as hypertension, hyperglycemia, dyslipidemia and abdominal obesity, is a prevalent health hazard worldwide. The increasing prevalence, affecting around 25% of the global population, can be attributed to changes in lifestyle and diet. Early diagnosis and treatment strategies are crucial for preventing further health deterioration.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Article
Medicine, General & Internal
Amit Alam, Johanna Van Zyl, Navdeep Nayyar, Shelley Hall, Rita Jermyn
Summary: A retrospective analysis of 29 HFpEF patients with CardioMEMS implantation showed that optimizing PADP through hemodynamic monitoring led to improvements in comorbidities related to metabolic syndrome, including obesity, hypertension, and dyslipidemia. However, the effect on glycemic control in diabetic patients was limited. Further studies are needed to validate these findings and determine their clinical significance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Livia Bertazzo Sacilotto, Silvia Justina Papini, Adriana Lucia Mendes, Mariana Gatto, Paulo Camara Marques Pereira, Jose Eduardo Corrente, Julhiany de Fatima da Silva
Summary: This study compared and correlated body composition, biochemical metabolic parameters, and levels of adipocytokines and cytokines of PLWHA with and without lipodystrophy, with individuals with negative HIV serology. The results suggest a high-risk endocrine metabolic profile for cardiovascular events in PLWHA, especially those with lipodystrophy, emphasizing the importance of comprehensive treatment approaches.
FRONTIERS IN NUTRITION
(2021)
Review
Pharmacology & Pharmacy
Matthew Weichseldorfer, Marvin Reitz, Olga S. Latinovic
Summary: Combined antiretroviral therapy (cART) is widely recommended for controlling HIV-1 replication and improving the quality of life of infected individuals. However, latent infected cells remain a major barrier to treatment efficacy in the long term.
Article
Biochemistry & Molecular Biology
Roberto Arrigoni, Luigi Santacroce, Andrea Ballini, Luigi Leonardo Palese
Summary: The availability of drugs capable of blocking microorganism replication is a major accomplishment in medicine, but the increasing number of resistant strains poses a significant challenge for infectious disease treatment. Therefore, the search for new potential ligands for pathogens' life cycle is a crucial research area today.
Article
Hematology
Azra Borogovac, Jessica A. Reese, Samiksha Gupta, James N. George
Summary: Hereditary thrombotic thrombocytopenic purpura (hTTP) is a rare disorder that often results in severe health issues and premature death. Current prophylaxis methods are not sufficient, highlighting the need for increased awareness and earlier implementation of more effective prevention treatments.
Article
Immunology
Lais Garreto, Sebastien Charneau, Samuel Coelho Mandacaru, Otavio T. Nobrega, Flavia N. Motta, Carla N. de Araujo, Audrey C. Tonet, Flavia M. B. Modesto, Lilian M. Paula, Marcelo Valle de Sousa, Jaime M. Santana, Ana Carolina Acevedo, Izabela M. D. Bastos
Summary: This study identified increased activity of the serine protease DPP4 and an increased tendency in expression of matrix metalloproteinase MMP9 in saliva of patients with Sjogren's Syndrome. Different proteases were analyzed in saliva samples, paving the way for potential biomarkers in the future.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Malcolm A. Leissring
Summary: There are still many important unresolved questions in the field of IDE, such as how IDE interacts with extracellular substrates, its localization and functional roles within the cell, and how it avoids getting clogged and losing activity. The author provides personal insights and experimental strategies to address these challenges, aiming to advance the research on the physiology and pathophysiology of IDE with the development of new technologies and specific reagents.
Article
Neurosciences
Candice A. Myers, Jeffrey N. Keller, H. Raymond Allen, Robert M. Brouillette, Heather Foil, Allison B. Davis, Frank L. Greenway, William D. Johnson, Corby K. Martin
JOURNAL OF ALZHEIMERS DISEASE
(2016)
Article
Neurosciences
Hisham Qosa, Loqman A. Mohamed, Sweilem B. Al Rihani, Yazan S. Batarseh, Quoc-Viet Duong, Jeffrey N. Keller, Amal Kaddoumi
JOURNAL OF ALZHEIMERS DISEASE
(2016)
Article
Multidisciplinary Sciences
Rebecca K. MacAulay, Ted Allaire, Robert Brouillette, Heather Foil, Annadora J. Bruce-Keller, Jeffrey N. Keller
Article
Psychology, Clinical
Rebecca K. MacAulay, Matthew R. Calamia, Alex S. Cohen, Katrina Daigle, Heather Foil, Robert Brouillette, Annadora J. Bruce-Keller, Jeffrey N. Keller
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2018)
Article
Geriatrics & Gerontology
Stephen R. Rapp, Jose A. Luchsinger, Laura D. Baker, George L. Blackburn, Helen P. Hazuda, Kathryn E. Demos-McDermott, Robert W. Jeffery, Jeffrey N. Keller, Jeanne M. McCaffery, Nicholas M. Pajewski, Mary Evans, Thomas A. Wadden, Steven E. Arnold, Mark A. Espeland
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2017)
Article
Geriatrics & Gerontology
O. T. Carmichael, S. Pillai, P. Shankapal, A. McLellan, D. G. Kay, B. T. Gold, J. N. Keller
JOURNAL OF NUTRITION HEALTH & AGING
(2018)
Article
Psychology, Clinical
John P. K. Bernstein, Matthew Calamia, Jeffrey N. Keller
Article
Psychology, Clinical
Matthew Calamia, Alyssa De Vito, John P. K. Bernstein, Daniel S. Weitzner, Owen T. Carmichael, Jeffrey N. Keller
Article
Biochemistry & Molecular Biology
Le Zhang, Sun-Ok Fernandez-Kim, Tina L. Beckett, Dana M. Niedowicz, Katharina Kohler, Kalavathi Dasuri, Annadora J. Bruce-Keller, M. Paul Murphy, Jeffrey N. Keller
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Article
Medicine, Research & Experimental
Amanda N. Szabo-Reed, Eric Vidoni, Ellen F. Binder, Jeffrey Burns, C. Munro Cullum, William P. Gahan, Aditi Gupta, Linda S. Hynan, Diana R. Kerwin, Heidi Rossetti, Ann M. Stowe, Wanpen Vongpatanasin, David C. Zhu, Rong Zhang, Jeffrey N. Keller
CONTEMPORARY CLINICAL TRIALS
(2019)
Article
Geriatrics & Gerontology
John P. K. Bernstein, Alyssa De Vito, Daniel S. Weitzner, Rebecca MacAulay, Matthew Calamia, Robert Brouillette, Heather Foil, Owen T. Carmichael, Jeffrey N. Keller
Review
Neurosciences
Romina Maria Uranga, Jeffrey Neil Keller
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Medicine, General & Internal
H. Raymond Allen, Doug Boudreaux, Jeffrey N. Keller
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Nutrition & Dietetics
Candida J. Rebello, Stephen Boue, Ronald J. Levy, Renee Puyau, Robbie A. Beyl, Frank L. Greenway, Mark L. Heiman, Jeffrey N. Keller, Charles F. Reynolds, John P. Kirwan
Summary: This study examined the safety of soybean products in Western diets and conducted a dose-escalating clinical trial in older adults with obesity. The results showed that consuming less than 30g of soybean flour per day is beneficial for cardiovascular and overall health, and can reduce the dependence on other food groups and nutrients in older adults with obesity.
Article
Oncology
Le Zhang, Kalavathi Dasuri, Sun-Ok Fernandez-Kim, Annadora J. Bruce-Keller, Jeffrey N. Keller
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2016)