期刊
ANTIVIRAL RESEARCH
卷 80, 期 3, 页码 377-379出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2008.07.009
关键词
T-705; West Nile virus; Hamsters; Mice; 6-Fluoro-3-hydroxy-2-pyrazinecarboxamide
资金
- NIH [NO1-AI-15435, U54 AI-065357]
We describe herein that a pyrazine derivative, T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide), is protective for a lethal West Nile virus infection in rodents. Oral T-705 at 200 mg/kg administered twice daily beginning 4 h after subcutaneous (s.c.) viral challenge protected mice and hamsters against WNV-induced mortality, and reduced viral protein expression and viral RNA in brains. The minimal effective oral dose was between 20 and 65 mg/kg when administered twice a day beginning I day after viral s.c. challenge of mice. Treatment could be delayed out to 2 days after viral challenge to still achieve efficacy in mice. Further development of this compound should be considered for treatment of WNV. (C) 2008 Published by Elsevier B.V.
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