期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 29, 期 9, 页码 793-812出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2017.7276
关键词
lncRNA; snoRNA; ncRNA; miRNA; ROS; oxidative stress
资金
- German Research Foundation DFG [SFB 815 TP A1, SFB 834 TP A2, SFB 1039 TPA1]
- Goethe-University, Frankfurt
Significance: RNA is a heterogeneous class of molecules with the minority being protein coding. Noncoding RNAs (ncRNAs) are involved in translation and epigenetic control mechanisms of gene expression. Recent Advances: In recent years, the number of identified ncRNAs has dramatically increased and it is now clear that ncRNAs provide a complex layer of differential gene expression control. Critical Issues: NcRNAs exhibit interplay with redox regulation. Redox regulation alters the expression of ncRNAs; conversely, ncRNAs alter the expression of generator and effector systems of redox regulation in a complex manner, which will be the focus of this review article. Future Directions: Understanding the role of ncRNA in redox control will lead to the development of new strategies to alter redox programs. Given that many ncRNAs (particularly microRNAs [miRNAs]) change large gene sets, these molecules are attractive drug candidates; already, now miRNAs can be targeted in patients. Therefore, the development of ncRNA therapies focusing on these molecules is an attractive future strategy.
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