Mucosal Reactive Oxygen Species Are Required for Antiviral Response: Role of Duox in Influenza A Virus Infection

Dual Role of NOX2 in Respiratory Syncytial Virus- and Sendai Virus-Induced Activation of NF- B in Airway Epithelial Cells

(2014) K. Fink et al.   JOURNAL OF IMMUNOLOGY

Activation of TLR4 Is Required for the Synergistic Induction of Dual Oxidase 2 and Dual Oxidase A2 by IFN-  and Lipopolysaccharide in Human Pancreatic Cancer Cell Lines

(2013) Y. Wu et al.   JOURNAL OF IMMUNOLOGY

Dual Oxidase 2 Bidirectional Promoter Polymorphisms Confer Differential Immune Responses in Airway Epithelia

(2012) Changhong Xu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Dual Oxidase–1 Is Required for Airway Epithelial Cell Migration and Bronchiolar Reepithelialization after Injury

(2012) Stefan H. Gorissen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Nuclear Envelope Budding Enables Large Ribonucleoprotein Particle Export during Synaptic Wnt Signaling

(2012) Sean D. Speese et al.   CELL

Mucosal Reactive Oxygen Species Decrease Virulence by Disrupting Campylobacter jejuni Phosphotyrosine Signaling

(2012) Nicolae Corcionivoschi et al.   Cell Host & Microbe

Comparative Study of Influenza Virus Replication in MDCK Cells and in Primary Cells Derived from Adenoids and Airway Epithelium

(2012) N. A. Ilyushina et al.   JOURNAL OF VIROLOGY

Mice Deficient in Dual Oxidase Maturation Factors Are Severely Hypothyroid

(2012) Helmut Grasberger et al.   MOLECULAR ENDOCRINOLOGY

Hydrogen Peroxide Alters Splicing of Soluble Guanylyl Cyclase and Selectively Modulates Expression of Splicing Regulators in Human Cancer Cells

(2012) Gilbert J. Cote et al.   PLoS One

Emerging Roles for the Influenza A Virus Nuclear Export Protein (NEP)

(2012) Duncan Paterson et al.   PLoS Pathogens

Differential Host Determinants Contribute to the Pathogenesis of 2009 Pandemic H1N1 and Human H5N1 Influenza A Viruses in Experimental Mouse Models

(2011) Anna Otte et al.   AMERICAN JOURNAL OF PATHOLOGY

Dual Oxidase 2 is Essential for the Toll-Like Receptor 5-Mediated Inflammatory Response in Airway Mucosa

(2011) Jung-Hee Joo et al.   ANTIOXIDANTS & REDOX SIGNALING

Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors

(2011) Francesca Gaggini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Up-regulation and Sustained Activation of Stat1 Are Essential for Interferon-γ (IFN-γ)-induced Dual Oxidase 2 (Duox2) and Dual Oxidase A2 (DuoxA2) Expression in Human Pancreatic Cancer Cell Lines

(2011) Yongzhong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Hepatic Nuclear Superoxide Production by Glucose 6-Phosphate Dehydrogenase and NADPH Oxidase-4

(2011) Netanya Y. Spencer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NS1 protein of influenza A virus suppresses interferon-regulated activation of antigen-presentation and immune-proteasome pathways

(2011) J. R. Tisoncik et al.   JOURNAL OF GENERAL VIROLOGY

2009 pandemic H1N1 influenza A virus strains display differential pathogenicity in C57BL/6J but not BALB/c mice

(2011) Anna Otte et al.   Virulence

All-trans retinoic acid mediates DUOX2 expression and function in respiratory tract epithelium

(2010) Angela Lee Linderholm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IFNγ mediates DUOX2 expression via a STAT-independent signaling pathway

(2010) Thomas Hill et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dual oxidase in the intestinal epithelium of zebrafish larvae has anti-bacterial properties

(2010) Maria Vega Flores et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of hydrogen peroxide production by Duox in bronchial epithelial cells exposed toPseudomonas aeruginosa

(2010) Balázs Rada et al.   FEBS LETTERS

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Influenza H5N1 and H1N1 Virus Replication and Innate Immune Responses in Bronchial Epithelial Cells Are Influenced by the State of Differentiation

(2010) Renee W. Y. Chan et al.   PLoS One

H1N1pdm Influenza Infection in Hospitalized Cancer Patients: Clinical Evolution and Viral Analysis

(2010) Thiago Moreno L. Souza et al.   PLoS One

A Peroxidase/Dual Oxidase System Modulates Midgut Epithelial Immunity in Anopheles gambiae

(2010) S. Kumar et al.   SCIENCE

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression

(2010) Anton Soucy-Faulkner et al.   PLoS Pathogens

Mechanisms and Function of DUOX in Epithelia of the Lung

(2009) Horst Fischer   ANTIOXIDANTS & REDOX SIGNALING

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

(2009) Monique Gannagé et al.   Cell Host & Microbe

Regulation of DUOX by the Gαq-Phospholipase Cβ-Ca2+ Pathway in Drosophila Gut Immunity

(2009) Eun-Mi Ha et al.   DEVELOPMENTAL CELL

Influenza A virus-induced caspase-3 cleaves the histone deacetylase 6 in infected epithelial cells

(2009) Matloob Husain et al.   FEBS LETTERS

Oxidative epithelial host defense is regulated by infectious and inflammatory stimuli

(2009) Monica Valencia Gattas et al.   FREE RADICAL BIOLOGY AND MEDICINE

ATP-mediated Activation of the NADPH Oxidase DUOX1 Mediates Airway Epithelial Responses to Bacterial Stimuli

(2009) Agnes W. Boots et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells

(2009) S. Luxen et al.   JOURNAL OF CELL SCIENCE

RhoA GTPase Activation by TLR2 and TLR3 Ligands: Connecting via Src to NF- B

(2009) M. Manukyan et al.   JOURNAL OF IMMUNOLOGY

Redox modulation of global phosphatase activity and protein phosphorylation in intact skeletal muscle

(2009) Valerie P. Wright et al.   JOURNAL OF PHYSIOLOGY-LONDON

Coordination of multiple dual oxidase–regulatory pathways in responses to commensal and infectious microbes in drosophila gut

(2009) Eun-Mi Ha et al.   NATURE IMMUNOLOGY

Lung Epithelial Injury by B. Anthracis Lethal Toxin Is Caused by MKK-Dependent Loss of Cytoskeletal Integrity

(2009) Mandy Lehmann et al.   PLoS One

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silencing of DUOX NADPH Oxidases by Promoter Hypermethylation in Lung Cancer

(2008) S. Luxen et al.   CANCER RESEARCH

E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35

(2008) G Merdzhanova et al.   CELL DEATH AND DIFFERENTIATION

Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation

(2008) Stanislas Morand et al.   FASEB JOURNAL

Inhibitory Action of NoxA1 on Dual Oxidase Activity in Airway Cells

(2008) Sandrine Pacquelet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational Analysis Reveals Distinct Features of the Nox4-p22phoxComplex

(2008) Katharina von Löhneysen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The multifunctional NS1 protein of influenza A viruses

(2008) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

Influenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression

(2008) Eva-K. Pauli et al.   PLoS Pathogens

Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl

(2007) Amina El Jamali et al.   FREE RADICAL BIOLOGY AND MEDICINE