Lung Injury and Lung Cancer Caused by Cigarette Smoke-Induced Oxidative Stress: Molecular Mechanisms and Therapeutic Opportunities Involving the Ceramide-Generating Machinery and Epidermal Growth Factor Receptor
出版年份 2014 全文链接
标题
Lung Injury and Lung Cancer Caused by Cigarette Smoke-Induced Oxidative Stress: Molecular Mechanisms and Therapeutic Opportunities Involving the Ceramide-Generating Machinery and Epidermal Growth Factor Receptor
作者
关键词
-
出版物
ANTIOXIDANTS & REDOX SIGNALING
Volume 21, Issue 15, Pages 2149-2174
出版商
Mary Ann Liebert Inc
发表日期
2014-03-31
DOI
10.1089/ars.2013.5469
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Cigarette Smoke Activates the Proto-Oncogene c-Src to Promote Airway Inflammation and Lung Tissue Destruction
- (2013) Patrick Geraghty et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1
- (2013) Christel Cinq-Frais et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- A Phase II Trial of Saracatinib, an Inhibitor of src Kinases, in Previously-Treated Advanced Non–Small-Cell Lung Cancer: The Princess Margaret Hospital Phase II Consortium
- (2013) Scott A. Laurie et al. Clinical Lung Cancer
- New Molecular Targets in the Treatment of NSCLC
- (2013) Clorinda Schettino et al. CURRENT PHARMACEUTICAL DESIGN
- Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis
- (2013) Nobuyoshi Kosaka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Src Mediates Cigarette Smoke-Induced Resistance to Tyrosine Kinase Inhibitors in NSCLC Cells
- (2013) S. Filosto et al. MOLECULAR CANCER THERAPEUTICS
- Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse Models
- (2013) Irina Petrache et al. PLoS One
- Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial
- (2013) William MacNee et al. THORAX
- RTP801 Is Required for Ceramide-Induced Cell-Specific Death in the Murine Lung
- (2012) Krzysztof Kamocki et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Nuclear Factor Erythroid 2-Related Factor 2 Nuclear Translocation Induces Myofibroblastic Dedifferentiation in Idiopathic Pulmonary Fibrosis
- (2012) Elise Artaud-Macari et al. ANTIOXIDANTS & REDOX SIGNALING
- Oxidative stress in apoptosis and cancer: an update
- (2012) José M. Matés et al. ARCHIVES OF TOXICOLOGY
- The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes
- (2012) Weihong Hou et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Loss of the Ceramide Transfer Protein Augments EGF Receptor Signaling in Breast Cancer
- (2012) J. Heering et al. CANCER RESEARCH
- Galectin-1 Promotes Lung Cancer Progression and Chemoresistance by Upregulating p38 MAPK, ERK, and Cyclooxygenase-2
- (2012) L.-Y. Chung et al. CLINICAL CANCER RESEARCH
- Lifting the fog of scientometric research artifacts: On the scientometric analysis of environmental tobacco smoke research
- (2012) Petr Heneberg JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY
- Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema
- (2012) Christophe Poirier et al. MAMMALIAN GENOME
- Cigarette Smoke Induces Aberrant EGF Receptor Activation That Mediates Lung Cancer Development and Resistance to Tyrosine Kinase Inhibitors
- (2012) S. Filosto et al. MOLECULAR CANCER THERAPEUTICS
- Role of antioxidants in cancer therapy
- (2012) Vanessa Fuchs-Tarlovsky NUTRITION
- Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A
- (2012) Shyamala Ganesan et al. THORAX
- The Role of Apoptosis-Induced Proliferation for Regeneration and Cancer
- (2012) H. D. Ryoo et al. Cold Spring Harbor Perspectives in Biology
- Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine
- (2012) J J Gills et al. Cell Death & Disease
- Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides
- (2011) Kelly S. Schweitzer et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease
- (2011) Juan P. de Torres et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Clinical responses to EGFR-tyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis
- (2011) Satoshi Watanabe et al. BMC CANCER
- Microvesicles: Messengers and mediators of tumor progression
- (2011) Khalid Al-Nedawi et al. CELL CYCLE
- Neutral Sphingomyelinase 2 Activity and Protein Stability Are Modulated by Phosphorylation of Five Conserved Serines
- (2011) Simone Filosto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Many Ceramides
- (2011) Yusuf A. Hannun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Incidence ofEGFRExon 19 Deletions and L858R in Tumor Specimens From Men and Cigarette Smokers With Lung Adenocarcinomas
- (2011) Sandra P. D'Angelo et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase II Trial of Dasatinib for Patients with Acquired Resistance to Treatment with the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Erlotinib or Gefitinib
- (2011) Melissa L. Johnson et al. Journal of Thoracic Oncology
- From Rous sarcoma virus to plasminogen activator, src oncogene and cancer management
- (2011) M Sudol ONCOGENE
- EGF Receptor Exposed to Oxidative Stress Acquires Abnormal Phosphorylation and Aberrant Activated Conformation That Impairs Canonical Dimerization
- (2011) Simone Filosto et al. PLoS One
- Chronic Obstructive Pulmonary Disease and Lung Cancer: New Molecular Insights
- (2011) Ian M. Adcock et al. RESPIRATION
- Acute Lung Injury: How Macrophages Orchestrate Resolution of Inflammation and Tissue Repair
- (2011) Susanne Herold et al. Frontiers in Immunology
- Lung Injury and Cancer
- (2010) Tzipora Goldkorn et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Neutral Sphingomyelinase 2
- (2010) Simone Filosto et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Novel monoclonal antibodies recognizing the active conformation of epidermal growth factor receptor
- (2010) Nobuyuki Ise et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- EGFR mutations and the terminal respiratory unit
- (2010) Yasushi Yatabe CANCER AND METASTASIS REVIEWS
- Vascular Barrier Regulation by PAF, Ceramide, Caveolae, and NO - an Intricate Signaling Network with Discrepant Effects in the Pulmonary and Systemic Vasculature
- (2010) Wolfgang M. Kuebler et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Kinase-mediated quasi-dimers of EGFR
- (2010) Erez M. Bublil et al. FASEB JOURNAL
- Ceramide-rich platforms in transmembrane signaling
- (2010) Branka Stancevic et al. FEBS LETTERS
- Neutral Sphingomyelinase 2 (nSMase2) Is a Phosphoprotein Regulated by Calcineurin (PP2B)
- (2010) Simone Filosto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
- (2010) Nobuyoshi Kosaka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors
- (2010) Xi Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR Signaling
- (2010) P. Otahal et al. JOURNAL OF IMMUNOLOGY
- Comparison of gefitinib and erlotinib in advanced NSCLC and the effect of EGFR mutations
- (2010) Jenn-Yu Wu et al. LUNG CANCER
- Spatial control of EGF receptor activation by reversible dimerization on living cells
- (2010) Inhee Chung et al. NATURE
- Mammalian Neutral Sphingomyelinases: Regulation and Roles in Cell Signaling Responses
- (2010) Bill X. Wu et al. NEUROMOLECULAR MEDICINE
- Stress-Induced Sphingolipid Signaling: Role of Type-2 Neutral Sphingomyelinase in Murine Cell Apoptosis and Proliferation
- (2010) Raphael Devillard et al. PLoS One
- Functional delivery of viral miRNAs via exosomes
- (2010) D. M. Pegtel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death
- (2009) Michal Levy et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Epithelial Cell Apoptosis Causes Acute Lung Injury Masquerading as Emphysema
- (2009) Majd Mouded et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src@
- (2009) Byung Chung et al. BMC CELL BIOLOGY
- Uncovering Growth-Suppressive MicroRNAs in Lung Cancer
- (2009) X. Liu et al. CLINICAL CANCER RESEARCH
- Platelet-activating factor reduces endothelial nitric oxide production: role of acid sphingomyelinase
- (2009) Y. Yang et al. EUROPEAN RESPIRATORY JOURNAL
- Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: Roles of the MAP kinases ERK1/2and JNK
- (2009) D. Goven et al. FEBS LETTERS
- A Randomized, Placebo-Controlled Study of the Effects of the p38 MAPK Inhibitor SB-681323 on Blood Biomarkers of Inflammation in COPD Patients
- (2009) Dave Singh et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Cigarette Smoke, Inflammation, and Lung Injury: A Mechanistic Perspective
- (2009) Deepak K. Bhalla et al. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
- c-Src Associates with ErbB2 through an Interaction between Catalytic Domains and Confers Enhanced Transforming Potential
- (2009) R. Marcotte et al. MOLECULAR AND CELLULAR BIOLOGY
- Biogenesis of small RNAs in animals
- (2009) V. Narry Kim et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants
- (2009) B M Chung et al. ONCOGENE
- Nrf2 protects against airway disorders
- (2009) Hye-Youn Cho et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Sphingolipids in the Lungs
- (2008) Stefan Uhlig et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1
- (2008) Deepti Malhotra et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Src as a potential therapeutic target in non-small-cell lung cancer
- (2008) G. Giaccone et al. ANNALS OF ONCOLOGY
- Ceramide-enriched membrane domains—Structure and function
- (2008) Yang Zhang et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Effects of ceramide and other simple sphingolipids on membrane lateral structure
- (2008) Félix M. Goñi et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
- (2008) Xi Chen et al. CELL RESEARCH
- Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke
- (2008) Alberto Izzotti et al. FASEB JOURNAL
- Cholesterol displacement by ceramide in sphingomyelin-containing liquid-ordered domains, and generation of gel regions in giant lipidic vesicles
- (2008) Jesús Sot et al. FEBS LETTERS
- Targeted Induction of Lung Endothelial Cell Apoptosis Causes Emphysema-like Changes in the Mouse
- (2008) Ricardo J. Giordano et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- EGFR tyrosine kinase inhibitors for the treatment of NSCLC in East Asia: present and future
- (2008) Chih-Hsin Yang LUNG CANCER
- Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK
- (2008) Klaus Dittmann et al. Molecular Cancer
- Regulation of Neutral Sphingomyelinase-2 (nSMase2) by Tumor Necrosis Factor- Involves Protein Kinase C- in Lung Epithelial Cells
- (2008) C. J. Clarke et al. MOLECULAR PHARMACOLOGY
- Somatic mutations affect key pathways in lung adenocarcinoma
- (2008) Li Ding et al. NATURE
- Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
- (2008) Khalid Al-Nedawi et al. NATURE CELL BIOLOGY
- Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
- (2008) Johan Skog et al. NATURE CELL BIOLOGY
- Circulating microRNAs as stable blood-based markers for cancer detection
- (2008) P. S. Mitchell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema
- (2008) D Goven et al. THORAX
- Mechanisms of Disease: signal transduction in lung carcinogenesis—a comparison of smokers and never-smokers
- (2008) Giannis Mountzios et al. Nature clinical practice. Oncology
- Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking
- (2007) Elaine M. Khan et al. FASEB JOURNAL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started