Mitochondria-Mediated Energy Adaption in Cancer: The H+-ATP Synthase-Geared Switch of Metabolism in Human Tumors

Cancer Abolishes the Tissue Type-Specific Differences in the Phenotype of Energetic Metabolism

(2014) Paloma Acebo et al.   Translational Oncology

miR-127-5p targets the 3′UTR of human β-F1-ATPase mRNA and inhibits its translation

(2012) Imke M. Willers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

(2012) Laura Formentini et al.   MOLECULAR CELL

Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state

(2012) P. Mergenthaler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reverse phase protein microarrays quantify and validate the bioenergetic signature as biomarker in colorectal cancer

(2011) M. Aldea et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression

(2011) Simon Hu et al.   Cell Metabolism

Inhibition of Alanine Aminotransferasein Silicoandin VivoPromotes Mitochondrial Metabolism to Impair Malignant Growth

(2011) Gregor Beuster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal Transduction by Mitochondrial Oxidants

(2011) Toren Finkel   JOURNAL OF BIOLOGICAL CHEMISTRY

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil

(2011) María Sánchez-Aragó et al.   Journal of Translational Medicine

Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels

(2011) Xiao Wang et al.   Molecular Oncology

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase

(2011) Kambiz N. Alavian et al.   NATURE CELL BIOLOGY

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Peroxisome proliferator-activated receptor-  coactivator 1-  (PGC1 ) is a metabolic regulator of intestinal epithelial cell fate

(2011) I. D'Errico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

(2011) Olivier Keunen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

(2011) T. N. Chonghaile et al.   SCIENCE

Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment

(2010) Gabriel Arismendi-Morillo   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Post-transcriptional regulation of the mitochondrial H+-ATP synthase: A key regulator of the metabolic phenotype in cancer

(2010) Imke M. Willers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

(2010) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Selection of cancer cells with repressed mitochondria triggers colon cancer progression

(2010) María Sánchez-Aragó et al.   CARCINOGENESIS

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The mitochondrial bioenergetic capacity of carcinomas

(2010) Laura Formentini et al.   IUBMB LIFE

Up-regulation of the ATPase Inhibitory Factor 1 (IF1) of the Mitochondrial H+-ATP Synthase in Human Tumors Mediates the Metabolic Shift of Cancer Cells to a Warburg Phenotype

(2010) Laura Sánchez-Cenizo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human G3BP1 interacts with  -F1-ATPase mRNA and inhibits its translation

(2010) A. D. Ortega et al.   JOURNAL OF CELL SCIENCE

p32 (C1QBP) and Cancer Cell Metabolism: Is the Warburg Effect a Lot of Hot Air?

(2010) C. V. Dang   MOLECULAR AND CELLULAR BIOLOGY

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance

(2009) R. J. Li et al.   ANNALS OF ONCOLOGY

Selective inhibition of β-F1-ATPase mRNA translation in human tumours

(2009) Imke M. Willers et al.   BIOCHEMICAL JOURNAL

The tumor suppressor function of mitochondria: Translation into the clinics

(2009) José M. Cuezva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Poly(ADP-ribose) Catabolism Triggers AMP-dependent Mitochondrial Energy Failure

(2009) Laura Formentini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype

(2009) Ad JC de Groof et al.   Molecular Cancer

Ovarian carcinoma cells with low levels of  -F1-ATPase are sensitive to combined platinum and 2-deoxy-D-glucose treatment

(2009) E. Hernlund et al.   MOLECULAR CANCER THERAPEUTICS

Association of survival and disease progression with chromosomal instability: A genomic exploration of colorectal cancer

(2009) M. Sheffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

HuR and the bioenergetic signature of breast cancer: a low tumor expression of the RNA-binding protein predicts a higher risk of disease recurrence

(2008) Álvaro D. Ortega et al.   CARCINOGENESIS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Dimer ribbons of ATP synthase shape the inner mitochondrial membrane

(2008) Mike Strauss et al.   EMBO JOURNAL

Expression of β-F1-ATPase and mitochondrial transcription factor A and the change in mitochondrial DNA content in colorectal cancer: clinical data analysis and evidence from an in vitro study

(2008) Pei-Ching Lin et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Hypoxia-inducible factor 1 and cancer pathogenesis

(2008) Gregg L. Semenza   IUBMB LIFE

Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

(2008) Thomas McFate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

Disruption of the hexokinase–VDAC complex for tumor therapy

(2008) L Galluzzi et al.   ONCOGENE

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE