Transcriptional Repression of Mitochondrial Function in Aging: A Novel Role for the Silencing Mediator of Retinoid and Thyroid Hormone Receptors Co-Repressor

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

(2016) Yuliya V. Dubrovsky et al.   Aging-US

Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training

(2011) Frederic Derbré et al.   AGE

Nucleus-encoded regulators of mitochondrial function: Integration of respiratory chain expression, nutrient sensing and metabolic stress

(2011) Richard C. Scarpulla   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

(2011) Hiroyasu Yamamoto et al.   CELL

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

(2011) Pingping Li et al.   CELL

Crosstalk between Components of Circadian and Metabolic Cycles in Mammals

(2011) Gad Asher et al.   Cell Metabolism

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

(2011) Maryam Ahmadian et al.   Cell Metabolism

Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice

(2011) Tsuneaki Kawashima et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Circadian Metabolic Regulation through Crosstalk between Casein Kinase 1δ and Transcriptional Coactivator PGC-1α

(2011) Siming Li et al.   MOLECULAR ENDOCRINOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Thyroid hormone receptor repression is linked to type I pneumocyte–associated respiratory distress syndrome

(2011) Liming Pei et al.   NATURE MEDICINE

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding

(2010) Gad Asher et al.   CELL

Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

(2010) Hui-Young Lee et al.   Cell Metabolism

Nuclear Receptor Corepressor SMRT Regulates Mitochondrial Oxidative Metabolism and Mediates Aging-Related Metabolic Deterioration

(2010) Shannon M. Reilly et al.   Cell Metabolism

Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation

(2010) Sihao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) Regulates Adipose Tissue Accumulation and Adipocyte Insulin Sensitivityin Vivo

(2010) Maria M. Sutanto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Twist-1 Is a PPARδ-Inducible, Negative-Feedback Regulator of PGC-1α in Brown Fat Metabolism

(2009) Dongning Pan et al.   CELL

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Metabolic Syndrome and Periodontitis: Is Oxidative Stress a Common Link?

(2009) P. Bullon et al.   JOURNAL OF DENTAL RESEARCH

The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis

(2009) Brendon J. Gurd et al.   JOURNAL OF PHYSIOLOGY-LONDON

Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

(2009) Y. C. Jang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Foxo1 integrates insulin signaling with mitochondrial function in the liver

(2009) Zhiyong Cheng et al.   NATURE MEDICINE

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Metabolic reprogramming, caloric restriction and aging

(2009) Rozalyn M. Anderson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

(2008) Kei Sakamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Vascular PPARγ Controls Circadian Variation in Blood Pressure and Heart Rate through Bmal1

(2008) Ningning Wang et al.   Cell Metabolism

Tissue-specific regulation of SIRT1 by calorie restriction

(2008) D. Chen et al.   GENES & DEVELOPMENT

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

(2008) Theresa Alenghat et al.   NATURE

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE

SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis

(2008) R. R. Nofsinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1 

(2008) A. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA