The p53/p21WAF/CIP Pathway Mediates Oxidative Stress and Senescence in Dyskeratosis Congenita Cells with Telomerase Insufficiency

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Level of reactive oxygen species induced by p21WAF(1)/CIP(1)is critical for the determination of cell fate

(2009) Takafumi Inoue et al.   CANCER SCIENCE

Proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, TERT, or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA component, TERC

(2009) Francoise A. Gourronc et al.   EXPERIMENTAL DERMATOLOGY

Telomeric DNA induces p53-dependent reactive oxygen species and protects against oxidative damage

(2009) Margaret S. Lee et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

(2009) Yvonne Begus-Nahrmann et al.   NATURE GENETICS

Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations

(2008) Michael Muller   ANTIOXIDANTS & REDOX SIGNALING

Increased levels of superoxide and H2O2mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation

(2008) Nùkhet Aykin-Burns et al.   BIOCHEMICAL JOURNAL

The many faces of telomerase: emerging extratelomeric effects

(2008) F. Mathias Bollmann   BIOESSAYS

Telomerase deficiency promotes oxidative stress by reducing catalase activity

(2008) G PEREZRIVERO et al.   FREE RADICAL BIOLOGY AND MEDICINE

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

(2008) S. Ahmed et al.   JOURNAL OF CELL SCIENCE

Telomeres and Aging

(2008) Geraldine Aubert et al.   PHYSIOLOGICAL REVIEWS