Article
Chemistry, Analytical
Yaqiong Kong, Xinjun Wan, Zhijun Liu, Feng Chen, Fengyi Wu, Guoxu Qin, Duojun Cao, Yong Cui
Summary: Nitroxyl (HNO), an active nitrogen species, plays a vital role in physiological and pathological processes. A fluorescent sensor NA-PA has been developed for selective detection of HNO with remarkable sensitivity and low cytotoxicity, showing potential for evaluating the physiological and pathological functions of HNO.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Kseniia Titenkova, Alexander D. Shuvaev, Fedor E. Teslenko, Egor S. Zhilin, Leonid L. Fershtat
Summary: Electrochemical synthesis is being used to create new strategies for the assembly of complex organic molecules. However, forming N-N bonds electrochemically is still challenging due to the electronegativity of nitrogen and side reactions. In this study, a green electrochemical approach was presented to selectively form N-N bonds using oximinohydrazones. The resulting 1,2,3-triazole 1-oxides possess thermally stability and show promise for the development of functional organic materials and pharmaceutical ingredients.
Article
Chemistry, Multidisciplinary
Chenyue Sun, Luming Yang, Manuel A. Ortuno, Ashley M. Wright, Tianyang Chen, Ashley R. Head, Nuria Lopez, Mircea Dinca
Summary: This study investigates the gas-solid reaction of nitric oxide with the metal-organic framework Cu-I-ZrTpmC* and identifies an unusual chelating N2O2.- intermediate using in situ spectroscopies and density functional theory simulations. The results highlight the advantage of site-isolation in metal-organic frameworks (MOFs) for studying important reaction intermediates and provide a mechanistic scenario compatible with the proposed one-electron couple in these enzymes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Nanoscience & Nanotechnology
Takayuki Harada, Yoshinori Okada
Summary: Metallic delafossites, as layered oxides with quasi-two-dimensional conduction layers, possess high conductivity and surface polarity. They can be utilized in thin films and heterostructures.
Article
Chemistry, Multidisciplinary
Stephan P. Blum, Christean Nickel, Lukas Schaffer, Tarik Karakaya, Siegfried R. Waldvogel
Summary: This study demonstrates the electrochemical aromatic nitration using NBu4NO2 as the nitro source, with 1,1,1-3,3,3-hexafluoroisopropan-2-ol (HFIP) in MeCN significantly increasing the yield by solvent control. The reaction is scalable and shows yields of up to 88%.
Review
Agronomy
Jagdish K. Ladha, Mark B. Peoples, Pallavolu M. Reddy, Jatish C. Biswas, Alan Bennett, Mangi L. Jat, Timothy J. Krupnik
Summary: This review examines the importance of biological nitrogen fixation in crop production and the contribution of nitrogen sources on a global scale. Strategies to enhance the efficiency of biological nitrogen fixation are discussed, along with the challenges and potential of introducing biological nitrogen fixation into conventional and alternative crop management systems.
FIELD CROPS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yelu Shi, Matthew A. Michael, Yong Zhang
Summary: This work elucidates the basic mechanism of the nonheme enzyme-mediated conversion of HNO to NO, resolving longstanding debates on reversibility and uncovering the reasons for the irreversible nature of this conversion. The study also identifies the first thermodynamically favorable and kinetically feasible mechanism for the experimental reverse reaction, providing insights that will aid in further related studies and the development of HNO probes.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Lander Hollevoet, Elise Vervloessem, Yury Gorbanev, Anton Nikiforov, Nathalie De Geyter, Annemie Bogaerts, Johan A. Martens
Summary: Industrial ammonia production without CO2 emission and with low energy consumption is a major challenge. Current methods relying on thermally activated iron catalysts at high pressure and continuous operation mode are difficult to electrify. Electrochemical solutions face issues with the inertness of nitrogen molecules on electrodes. This study proposes an oxidative route for N-2 activation as an energy-efficient option for small-scale distributed ammonia production with renewable electricity and without intrinsic CO2 footprint.
Article
Environmental Sciences
M. Thuerkow, S. Banzhaf, T. Butler, J. Pueltz, M. Schaap
Summary: Millions of people are exposed to high levels of nitrogen dioxide in urban areas, which has severe health effects. Understanding the contributions of different source sectors to nitrogen oxide levels is crucial for reducing nitrogen oxides and improving human health.
ATMOSPHERIC ENVIRONMENT
(2023)
Article
Polymer Science
Meike N. Leiske, Ronak Singha, Somdeb Jana, Bruno G. De Geest, Richard Hoogenboom
Summary: In the past two decades, research on thermoresponsive polymers based on tertiary amine groups has been extensive, especially in their application in the biomedical field due to their temperature-dependent phase transition that can be modulated by the pH value of the environment. In this study, methyl-ester-functionalised poly(2-alkyl-2-oxazoline)s (PAOx) were used as a versatile platform for the synthesis of tertiary-amine-functionalised PAOx via post-polymerisation amidation. The resulting polymers showed responsiveness to pH value and temperature, forming polymeric nanoparticles, which demonstrated potential in polymeric drug delivery and inhibiting the proliferation of breast cancer cells.
Article
Engineering, Environmental
Samuel C. Capp, David A. G. Sawtell, Craig E. Banks, Peter J. Kelly, Zaenab Abd-Allah
Summary: The study investigated the effects of combining titanium dioxide with non-thermal plasma, leading to increased ozone and N2O5 production while reducing harmful byproducts like NO2 and N2O. The presence of TiO2 affected plasma chemistry by acting as a sink for atomic oxygen and altering the dielectric constant of the BaTiO3 particulates. Annealing the surface improved TiO2 photocatalytic activity, enabling enhanced ozone and N2O5 formation while decreasing NO2 and N2O production.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Inorganic & Nuclear
Dieter Rehder
Summary: This review focuses on the environmental availability of vanadium, its impact on the various spheres of life (geo-sphere, atmosphere, marine environments), and its potential in treating diseases like cancer, diabetes, and bacterial infections. It discusses vanadium in marine environments, its role in nitrogen fixation, vanadium in the fly agaric mushroom, vanadium speciation in unicellular organisms, and the potential benefits of vanadium compounds in disease treatment.
INORGANICA CHIMICA ACTA
(2023)
Review
Nanoscience & Nanotechnology
Grant A. Knappe, Eike-Christian Wamhoff, Mark Bathe
Summary: DNA origami is a powerful method for generating DNA nanostructures with dynamic properties and nanoscale control. This review focuses on the methods developed for functionalizing, purifying, and characterizing these nanostructures. The remaining challenges and potential areas of advancement in the fabrication of functionalized DNA origami are also discussed.
NATURE REVIEWS MATERIALS
(2023)
Review
Chemistry, Inorganic & Nuclear
Yongqing Zhou, Xiaofeng Yang, Jing Zhang, Shuai Xu, Juan Li, Wenshou Wang, Mei Yan
Summary: Reactive nitrogen species (RNS), including nitric oxide (NO or NO.), peroxynitrite anion (ONOO-) and nitroxyl (HNO), play important roles in physiological, pathological and pharmacological processes. Abnormal variations in RNS concentrations are closely associated with the occurrence and progression of numerous diseases. Therefore, it is significant to visualize RNS for a better understanding of their distribution, roles, functions, interactions and mechanisms in biological systems. Fluorescence imaging technique and small molecule fluorescent probes have been widely used for the detection and monitoring of RNS in living systems. In this review, recent advances in small molecule fluorescent probes for monitoring NO, ONOO- and HNO are summarized, including their design strategies, recognition mechanisms and biological applications.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Inorganic & Nuclear
Edinilton Muniz Carvalho, Eduardo Henrique Silva Sousa, Vania Bernardes-Genisson, Luiz Gonzaga de Franca Lopes
Summary: Nitric oxide (NO.) and nitroxyl (HNO) have been widely studied as active agents in physiological and pathological processes. Their different physiological responses broaden their applications, requiring specific concentrations for their multiple biological effects, leading to the development of strategies for controlled and selective delivery. The wide range of activities of these compounds, along with the development of smart strategies for NO./HNO donors, have made them a hot spot in research and potential clinical applications.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Editorial Material
Multidisciplinary Sciences
Eva Doka, Elias S. J. Arner, Edward E. Schmidt, Tobias P. Dick, Albert van der Vliet, Jing Yang, Reka Szatmari, Tamas Ditroi, John L. Wallace, Giuseppe Cirino, Kenneth Olson, Hozumi Motohashi, Jon M. Fukuto, Michael D. Pluth, Martin Feelisch, Takaaki Akaike, David A. Wink, Louis J. Ignarro, Peter Nagy
Summary: The recent report by Fan et al. alleging the inadequacy of the ProPerDP method for protein persulfidation detection is not supported by their data and is based on methodological shortcomings. Their assumptions and conclusions have not been confirmed by other methods.
Review
Biochemistry & Molecular Biology
Christopher L. McGinity, Erika M. Palmieri, Veena Somasundaram, Dibyangana D. Bhattacharyya, Lisa A. Ridnour, Robert Y. S. Cheng, Aideen E. Ryan, Sharon A. Glynn, Douglas D. Thomas, Katrina M. Miranda, Stephen K. Anderson, Stephen J. Lockett, Daniel W. McVicar, David A. Wink
Summary: The metabolic requirements and functions of cancer and normal tissues differ significantly, with distorted vasculature and hypoxia-induced stress commonly observed in tumor microenvironments. Recent studies have shown that alterations in various metabolic pathways dictate tumor behavior and response to therapy, with metabolic heterogeneity within the tumor microenvironment playing a key role in promoting tumor behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Daniele Mancardi, Pasquale Pagliaro, Lisa A. Ridnour, Carlo G. Tocchetti, Katrina Miranda, Magdalena Juhaszova, Steven J. Sollott, David A. Wink, Nazareno Paolocci
Summary: Nitroxyl (HNO), the one electron-reduction product of nitric oxide (NO), can limit ischemia-reperfusion (I/R) injury by inhibiting the opening of mitochondrial permeability transition pore (mPTP). This study provides insights into the mechanisms of HNO-mediated cardioprotection.
Article
Biochemistry & Molecular Biology
Amir M. Alsharabasy, Sharon Glynn, Pau Farras, Abhay Pandit
Summary: The study investigated the binding affinity of hemin with (NO)-N-?, the internalization of hemin into MDA-MB-231 cells, and the changes in intracellular nitrated proteins. It also examined the nitration of bovine serum albumin after treatment with hemin and (NO)-N-?, considering factors such as reaction medium pH, H2O2 generation, and tyrosine residue oxidation. The results showed that hemin nitrosylation enhanced cellular uptake, induced protein nitration, and depended on (NO)-N-? concentration and reaction medium pH, with protein scavenging effects playing a crucial role.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Amy J. Burke, Jake D. McAuliffe, Alessandro Natoni, Sarah Ridge, Francis J. Sullivan, Sharon A. Glynn
Summary: NO plays a key role in the development and metastasis of prostate cancer, leading to DNA damage, cell migration, and increased resistance to chemotherapy.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Review
Oncology
Tejaswini P. Reddy, Sharon A. Glynn, Timothy R. Billiar, David A. Wink, Jenny C. Chang
Summary: Targeted therapies that reduce cancer metastasis, target chemoresistant cancer stem cells, and enhance the efficacy of systemic chemo/radiotherapies are crucial in reducing cancer-related mortality. Targeting nitric oxide synthase (NOS), a protein in the tumor microenvironment, has shown promise as a therapeutic strategy in various solid malignancies. This review examines the role of nitric oxide (NO) in tumor progression and metastasis, as well as preclinical studies evaluating NOS inhibitors as anticancer therapies. The prospects and challenges of using NOS inhibitors in a clinical setting are also discussed.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Veena Somasundaram, Lisa A. Ridnour, Robert Ys Cheng, Abigail J. Walke, Noemi Kedei, Dibyangana D. Bhattacharyya, Adelaide L. Wink, Elijah F. Edmondson, Donna Butcher, Andrew C. Warner, Tiffany H. Dorsey, David A. Scheiblin, William Heinz, Richard J. Bryant, Robert J. Kinders, Stanley Lipkowitz, Stephen T. C. Wong, Milind Pore, Stephen M. Hewitt, Daniel W. McVicar, Stephen K. Anderson, Jenny Chang, Sharon A. Glynn, Stefan Ambs, Stephen J. Lockett, David A. Wink
Summary: The levels of NOS2/COX2 in tumors influence the polarization and spatial location of lymphoid cells, including CD8(+) T cells. High levels of NOS2/COX2 are associated with the exclusion of CD8(+) T cells from the tumor epithelium. The drug inhibitor indomethacin can improve the penetration ability of CD8(+) T cells and reduce tumor growth, leading to tumor regression.
Article
Cell Biology
Robert Y. S. Cheng, Lisa A. Ridnour, Adelaide L. Wink, Ana L. Gonzalez, Elise L. Femino, Helene Rittscher, Veena Somasundaram, William F. Heinz, Leandro Coutinho, M. Cristina Rangel, Elijah F. Edmondson, Donna Butcher, Robert J. Kinders, Xiaoxian Li, Stephen T. C. Wong, Daniel W. McVicar, Stephen K. Anderson, Milind Pore, Stephen M. Hewitt, Timothy R. Billiar, Sharon A. Glynn, Jenny C. Chang, Stephen J. Lockett, Stefan Ambs, David A. Wink
Summary: A strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER breast cancer has been established. Analysis of TCGA revealed correlations between NOS2 and COX2 expression and Th1 cytokines. Single-cell RNAseq analysis of TNBC cells showed potent NOS2 and COX2 induction by IFN gamma combined with IL1 beta or TNF alpha.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Balint Cserni, Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bago-Horvath, Simonetta Bianchi, Ewa Chmielik, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Aniko Kovacs, Paivi Heikkila, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchio, Elena Provenzano, Peter Regitnig, Angelika Reiner, Ales Ryska, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Sharon A. Glynn, Rita Bori, Erika Csorgo, Orsolya Olah-Nemeth, Tamas Pancsa, Anita Sejben, Istvan Sejben, Andras Voros, Tamas Zombori, Tibor Nyari, Grace Callagy, Gabor Cserni
Summary: Tumour-infiltrating lymphocytes (TILs) reflect the host's response against tumours, especially in triple-negative breast cancers. ONEST helps in estimating the number of observers required for a more reliable estimation of inter-observer agreement in TIL assessments, which has not been explored previously. This analysis suggests that between six and nine pathologists can provide a good approximation of inter-observer agreement in TIL assessments.
Article
Biochemistry & Molecular Biology
Robert Y. S. Cheng, Sandra Burkett, Stefan Ambs, Terry Moody, David A. A. Wink, Lisa A. A. Ridnour
Summary: The small signaling molecule nitric oxide (NO) is associated with chronic inflammation and cancer. NO can have both protective and damaging effects on cells depending on its concentration and exposure time. In this study, chronic exposure to NO was found to cause altered phenotypes in breast epithelial cells, including changes in cellular morphology, genomic stability, and RNA and protein expression. These altered phenotypes were associated with malignant characteristics, such as increased expression of cancer stem cell marker CD44 and enhanced motility.
Article
Chemistry, Medicinal
Amir M. Alsharabasy, Amal Aljaabary, Raghvendra Bohara, Pau Farras, Sharon A. Glynn, Abhay Pandit
Summary: The study demonstrates that hemin can be used as a potential anticancer agent by scavenging nitric oxide (NO), inhibiting cancer cell migration, and regulating the expression of migration-associated proteins.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
